Abstract:
:Metabolic engineering is embraced as a method to sustainably enhance production of valuable phytochemicals with beneficial properties. However, successful production of these compounds in plants is not always predictable even when the pathways are fully known, frequently due to the lack of comprehensive understanding of plant metabolism as a whole, and interconnections between different primary, secondary, and hormone metabolic networks. Here, we highlight critical hidden constraints, including substrate availability, silent metabolism, and metabolic crosstalk, that impair engineering strategies. We explore how these constraints have historically been manifested in engineering attempts and propose how modern advancements will enable future strategies to overcome these impediments.
journal_name
Curr Opin Biotechnoljournal_title
Current opinion in biotechnologyauthors
Lynch JH,Huang XQ,Dudareva Ndoi
10.1016/j.copbio.2020.12.014subject
Has Abstractpub_date
2021-01-08 00:00:00pages
112-117eissn
0958-1669issn
1879-0429pii
S0958-1669(20)30200-7journal_volume
69pub_type
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journal_title:Current opinion in biotechnology
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journal_title:Current opinion in biotechnology
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