The application of DNA repair vectors to gene therapy.

Abstract:

:The nature of DNA, the sequence of the human genome and our increased understanding of the genetic basis of many inherited and acquired disorders have made the possibility of curing diseases a reality. The modulation of a host's genome is now the ultimate goal in the treatment of genetic diseases. Historically, gene therapy recognized two very different approaches: gene replacement or augmentation and gene repair. Gene repair precisely targets and corrects the chromosomal mutation responsible for a genetic and/or acquired disorder. Many recent advances have been made in this area of research.

journal_name

Curr Opin Biotechnol

authors

Kren BT,Steer CJ

doi

10.1016/s0958-1669(02)00370-1

subject

Has Abstract

pub_date

2002-10-01 00:00:00

pages

473-81

issue

5

eissn

0958-1669

issn

1879-0429

pii

S0958166902003701

journal_volume

13

pub_type

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