Origin and analysis of microbial population heterogeneity in bioprocesses.

Abstract:

:Heterogeneity of industrial production cultures is accepted to a certain degree; however, the underlying mechanisms are seldom perceived or included in the development of new bioprocess control strategies. Population heterogeneity and its basics, perceptible in the diverse proficiency of cells, begins with asymmetric birth and is found to recess during the life cycle. Since inefficient subpopulations have significant impact on the productivity of industrial cultures, cellular heterogeneity needs to be detected and quantified by using high speed detection tools like flow cytometry. Possible origins of population heterogeneity, sophisticated fluorescent techniques for detection of individual cell states, and cutting-edge Omics-technologies for extended information beyond the resolution of fluorescent labelling are highlighted.

journal_name

Curr Opin Biotechnol

authors

Müller S,Harms H,Bley T

doi

10.1016/j.copbio.2010.01.002

subject

Has Abstract

pub_date

2010-02-01 00:00:00

pages

100-13

issue

1

eissn

0958-1669

issn

1879-0429

pii

S0958-1669(10)00003-0

journal_volume

21

pub_type

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