Abstract:
:Several cell-based tissue-engineering therapies are emerging to regenerate damaged tissues. These strategies use autologous cells in combination with bioresorbable delivery materials. Major functions of a delivery scaffold are to provide initial mechanical stability, homogenous three-dimensional cell distribution, improved tissue differentiation, suitable handling and properties for delivery and fixation into patients. Delivery of cells can be achieved using injectable matrices, soft scaffolds, membranes, solid load-bearing scaffolds or immunoprotective macroencapsulation. Thus, to expand the clinical potential, next generation therapies will depend on smart delivery concepts that make use of the regenerative potential of stem cells, morphogenetic growth factors and biomimetic materials.
journal_name
Curr Opin Biotechnoljournal_title
Current opinion in biotechnologyauthors
Sittinger M,Hutmacher DW,Risbud MVdoi
10.1016/j.copbio.2004.08.010subject
Has Abstractpub_date
2004-10-01 00:00:00pages
411-8issue
5eissn
0958-1669issn
1879-0429pii
S0958-1669(04)00116-8journal_volume
15pub_type
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journal_title:Current opinion in biotechnology
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journal_title:Current opinion in biotechnology
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journal_title:Current opinion in biotechnology
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journal_title:Current opinion in biotechnology
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journal_title:Current opinion in biotechnology
pub_type: 杂志文章,评审
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journal_title:Current opinion in biotechnology
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