Advances in the clinical translation of nanotechnology.

Abstract:

:The use of novel materials in the nano-scale size range for applications in devices, drugs and diagnostic agents comes with a number of new opportunities, and also serious challenges to human applications. The larger size of particulate-based agents, as compared to traditional drugs, allows for the significant advantages of multivalency and multi-functionality. However, the human use of nanomaterials requires a thorough understanding of the biocompatibility of the synthetic molecules and their complex pharmacology. Possible toxicities created by the unusual properties of the nanoparticles are neither well-understood, nor predictable yet. A key to the successful use of the burgeoning field of nanomaterials as diagnostic and therapeutic agents will be to appropriately match the biophysical features of the particle to the disease system to be evaluated or treated.

journal_name

Curr Opin Biotechnol

authors

Scheinberg DA,Grimm J,Heller DA,Stater EP,Bradbury M,McDevitt MR

doi

10.1016/j.copbio.2017.01.002

subject

Has Abstract

pub_date

2017-08-01 00:00:00

pages

66-73

eissn

0958-1669

issn

1879-0429

pii

S0958-1669(16)30222-1

journal_volume

46

pub_type

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