Membrane platforms for biological nanopore sensing and sequencing.

Abstract:

:In the past two decades, biological nanopores have been developed and explored for use in sensing applications as a result of their exquisite sensitivity and easily engineered, reproducible, and economically manufactured structures. Nanopore sensing has been shown to differentiate between highly similar analytes, measure polymer size, detect the presence of specific genes, and rapidly sequence nucleic acids translocating through the pore. Devices featuring protein nanopores have been limited in part by the membrane support containing the nanopore, the shortcomings of which have been addressed in recent work developing new materials, approaches, and apparatus resulting in membrane platforms featuring automatability and increased robustness, lifetime, and measurement throughput.

journal_name

Curr Opin Biotechnol

authors

Schmidt J

doi

10.1016/j.copbio.2015.12.015

subject

Has Abstract

pub_date

2016-06-01 00:00:00

pages

17-27

eissn

0958-1669

issn

1879-0429

pii

S0958-1669(15)00178-0

journal_volume

39

pub_type

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