Top value platform chemicals: bio-based production of organic acids.


:Driven by the quest for sustainability, recent years have seen a tremendous progress in bio-based production routes from renewable raw materials to commercial goods. Particularly, the production of organic acids has crystallized as a competitive and fast-evolving field, related to the broad applicability of organic acids for direct use, as polymer building blocks, and as commodity chemicals. Here, we review recent advances in metabolic engineering and industrial market scenarios with focus on organic acids as top value products from biomass, accessible through fermentation and biotransformation.


Curr Opin Biotechnol


Becker J,Lange A,Fabarius J,Wittmann C




Has Abstract


2015-12-01 00:00:00












  • Potential of industrial biotechnology with cyanobacteria and eukaryotic microalgae.

    abstract::Both cyanobacteria and eukaryotic microalgae are promising organisms for sustainable production of bulk products such as food, feed, materials, chemicals and fuels. In this review we will summarize the potential and current biotechnological developments. Cyanobacteria are promising host organisms for the production of...

    journal_title:Current opinion in biotechnology

    pub_type: 杂志文章,评审


    authors: Wijffels RH,Kruse O,Hellingwerf KJ

    更新日期:2013-06-01 00:00:00

  • Gut brain axis: diet microbiota interactions and implications for modulation of anxiety and depression.

    abstract::The human gut microbiome is composed of an enormous number of microorganisms, generally regarded as commensal bacteria. Without this inherent microbial community, we would be unable to digest plant polysaccharides and would have trouble extracting lipids from our diet. Resident gut bacteria are an important contributo...

    journal_title:Current opinion in biotechnology

    pub_type: 杂志文章,评审


    authors: Luna RA,Foster JA

    更新日期:2015-04-01 00:00:00

  • Metabolic pathway compartmentalization: an underappreciated opportunity?

    abstract::For eukaryotic cells to function properly, they divide their intracellular space in subcellular compartments, each harboring specific metabolic activities. In recent years, it has become increasingly clear that compartmentalization of metabolic pathways is a prerequisite for certain cellular functions. This has for in...

    journal_title:Current opinion in biotechnology

    pub_type: 杂志文章,评审


    authors: Zecchin A,Stapor PC,Goveia J,Carmeliet P

    更新日期:2015-08-01 00:00:00

  • Metabolic engineering of Saccharomyces cerevisiae for production of butanol isomers.

    abstract::Saccharomyces cerevisiae has decisive advantages in industrial processes due to its tolerance to alcohols and fermentation conditions. Butanol isomers are considered as suitable fuel substitutes and valuable biomass-derived chemical building blocks. Whereas high production was achieved with bacterial systems, metaboli...

    journal_title:Current opinion in biotechnology

    pub_type: 杂志文章,评审


    authors: Generoso WC,Schadeweg V,Oreb M,Boles E

    更新日期:2015-06-01 00:00:00

  • Advances in quantitative proteomics via stable isotope tagging and mass spectrometry.

    abstract::The high-throughput identification and accurate quantification of proteins are essential components of proteomic strategies for studying cellular functions and processes. Techniques that are largely based on stable isotope protein or peptide labeling and automated tandem mass spectrometry are increasingly being applie...

    journal_title:Current opinion in biotechnology

    pub_type: 杂志文章,评审


    authors: Tao WA,Aebersold R

    更新日期:2003-02-01 00:00:00

  • Gene expression using Xenopus oocytes.

    abstract::Xenopus oocytes have been used as a surrogate genetic system for the study of many facets of gene expression. Some recent salient examples where injected oocytes proved to be indispensable for the analysis of transcription, translation, RNA/protein transport, and ion channel formation are described. ...

    journal_title:Current opinion in biotechnology

    pub_type: 杂志文章


    authors: Richter JD

    更新日期:1991-10-01 00:00:00

  • Linking marine biology and biotechnology.

    abstract::Studies of biological systems in which there is a direct link between the challenges faced by marine organisms and biotechnologies enable us to rationally search for active natural compounds and other novel biotechnologies. This approach is proving successful in developing new methods for the prevention of marine biof...

    journal_title:Current opinion in biotechnology

    pub_type: 杂志文章,评审


    authors: de Nys R,Steinberg PD

    更新日期:2002-06-01 00:00:00

  • Drinking water microbiology--from measurement to management.

    abstract::New microbial tools enable detailed quantification and characterization of complex drinking water (DW) microbiomes. Many opportunities exist from source to tap to apply this knowledge toward management of the microbiology. This requires consideration of the microbiome continuum across all phases harboring microbes (pl...

    journal_title:Current opinion in biotechnology

    pub_type: 杂志文章,评审


    authors: Proctor CR,Hammes F

    更新日期:2015-06-01 00:00:00

  • Engineering peripheral nerve repair.

    abstract::Current approaches for treating peripheral nerve injury have resulted in promising, yet insufficient functional recovery compared to the clinical standard of care, autologous nerve grafts. In order to design a construct that can match the regenerative potential of the autograft, all facets of nerve tissue must be inco...

    journal_title:Current opinion in biotechnology

    pub_type: 杂志文章,评审


    authors: Marquardt LM,Sakiyama-Elbert SE

    更新日期:2013-10-01 00:00:00

  • Novel approaches in food-processing technology: new technologies for preserving foods and modifying function.

    abstract::Recent advances in emerging food-processing technologies, such as high hydrostatic pressure or high-intensity electric field pulses, allow targeted and sophisticated modification and preservation of foods. We are beginning to understand the mechanisms involved in pressure inactivation of bacterial spores and have been...

    journal_title:Current opinion in biotechnology

    pub_type: 杂志文章,评审


    authors: Knorr D

    更新日期:1999-10-01 00:00:00

  • Algae biofuels: versatility for the future of bioenergy.

    abstract::The world continues to increase its energy use, brought about by an expanding population and a desire for a greater standard of living. This energy use coupled with the realization of the impact of carbon dioxide on the climate, has led us to reanalyze the potential of plant-based biofuels. Of the potential sources of...

    journal_title:Current opinion in biotechnology

    pub_type: 杂志文章,评审


    authors: Jones CS,Mayfield SP

    更新日期:2012-06-01 00:00:00

  • Recent developments of microfluidics as a tool for biotechnology and microbiology.

    abstract::Academic microfluidics has decisively shifted in recent years from the research on phenomenology and proof-of-concept fluidic functionalities to the developments oriented at applications with biology, medicine and biotechnology in prime focus. Significant efforts are made to demonstrate that microfluidics can be used ...

    journal_title:Current opinion in biotechnology

    pub_type: 杂志文章,评审


    authors: Scheler O,Postek W,Garstecki P

    更新日期:2019-02-01 00:00:00

  • Protein secretion in bacteria.

    abstract::Most secretory proteins are synthesized as precursors with an amino-terminal signal peptide. Genetic identification of proteins essential for signal peptide dependent translocation to the Escherichia coli periplasm has led to the biochemical dissection of the secretion pathway. Additional mechanisms exist in Gram-nega...

    journal_title:Current opinion in biotechnology

    pub_type: 杂志文章,评审


    authors: Gennity JM,Inouye M

    更新日期:1991-10-01 00:00:00

  • Local sequence-structure correlations in proteins.

    abstract::Considerable progress has been made in understanding the relationship between local amino acid sequence and local protein structure. Recent highlights include numerous studies of the structures adopted by short peptides, new approaches to correlating sequence patterns with structure patterns, and folding simulations u...

    journal_title:Current opinion in biotechnology

    pub_type: 杂志文章,评审


    authors: Bystroff C,Simons KT,Han KF,Baker D

    更新日期:1996-08-01 00:00:00

  • Selection of biologically active peptides by phage display of random peptide libraries.

    abstract::Random peptide libraries displayed on phage are used as a source of peptides for epitope mapping, for the identification of critical amino acids responsible for protein-protein interactions and as leads for the discovery of new therapeutics. Efficient and simple procedures have been devised to select peptides binding ...

    journal_title:Current opinion in biotechnology

    pub_type: 杂志文章,评审


    authors: Cortese R,Monaci P,Luzzago A,Santini C,Bartoli F,Cortese I,Fortugno P,Galfrè G,Nicosia A,Felici F

    更新日期:1996-12-01 00:00:00

  • Optimizing the fluorescent protein toolbox and its use.

    abstract::Fluorescent proteins (FPs) and fluorescent protein-derived biosensors are indispensable tools in life sciences. They make it possible to probe the location, activity, or interaction of molecules of interest from a subcellular to a multicellular scale. The desire for high-resolution and multidimensional information imp...

    journal_title:Current opinion in biotechnology

    pub_type: 杂志文章,评审


    authors: Duwé S,Dedecker P

    更新日期:2019-08-01 00:00:00

  • Microbial production and environmental applications of Pd nanoparticles for treatment of halogenated compounds.

    abstract::New biological inspired methods were recently developed to recover precious metals from waste streams and to concomitantly produce palladium nanoparticles on bacteria, that is, bio-Pd. This technology offers a variety of opportunities, as the process can considered to be green, tunable, affordable and scalable. The na...

    journal_title:Current opinion in biotechnology

    pub_type: 杂志文章,评审


    authors: Hennebel T,De Corte S,Verstraete W,Boon N

    更新日期:2012-08-01 00:00:00

  • Bacterial persistence from a system-level perspective.

    abstract::In recent years, our understanding about bacterial persistence has significantly advanced: we comprehend the persister phenotype better, more triggers for persistence entry have been found, and more insights in the involvement and role of toxin-antitoxin systems and other molecular mechanisms have been unravelled. In ...

    journal_title:Current opinion in biotechnology

    pub_type: 杂志文章,评审


    authors: Radzikowski JL,Schramke H,Heinemann M

    更新日期:2017-08-01 00:00:00

  • Biosynthesis of fatty acid-derived hydrocarbons: perspectives on enzymology and enzyme engineering.

    abstract::Enormous fuel consumption and growing environmental concerns have been spurring development of renewable biofuels. Among various biofuels, fatty acid-derived biohydrocarbons are ideal alternatives to non-renewable fossil fuels due to their closest properties to petroleum-based fuels. In the past decade, novel hydrocar...

    journal_title:Current opinion in biotechnology

    pub_type: 杂志文章,评审


    authors: Liu K,Li S

    更新日期:2020-04-01 00:00:00

  • Trash to treasure: production of biofuels and commodity chemicals via syngas fermenting microorganisms.

    abstract::Fermentation of syngas is a means through which unutilized organic waste streams can be converted biologically into biofuels and commodity chemicals. Despite recent advances, several issues remain which limit implementation of industrial-scale syngas fermentation processes. At the cellular level, the energy conservati...

    journal_title:Current opinion in biotechnology

    pub_type: 杂志文章,评审


    authors: Latif H,Zeidan AA,Nielsen AT,Zengler K

    更新日期:2014-06-01 00:00:00

  • Environmental monitoring using autonomous vehicles: a survey of recent searching techniques.

    abstract::Autonomous vehicles are becoming an essential tool in a wide range of environmental applications that include ambient data acquisition, remote sensing, and mapping of the spatial extent of pollutant spills. Among these applications, pollution source localization has drawn increasing interest due to its scientific and ...

    journal_title:Current opinion in biotechnology

    pub_type: 杂志文章,评审


    authors: Bayat B,Crasta N,Crespi A,Pascoal AM,Ijspeert A

    更新日期:2017-06-01 00:00:00

  • Road to precision: recombinase-based targeting technologies for genome engineering.

    abstract::In the past years, recombinase-based approaches for integrating transgenes into defined chromosomal loci of mammalian cells have gained increasing attention. This method is attractive since it enables to precisely integrate transgenes of interest into pre-defined integration sites, thereby allowing to predict the expr...

    journal_title:Current opinion in biotechnology

    pub_type: 杂志文章,评审


    authors: Wirth D,Gama-Norton L,Riemer P,Sandhu U,Schucht R,Hauser H

    更新日期:2007-10-01 00:00:00

  • Microfluidic cell culture models for tissue engineering.

    abstract::Microfluidic systems have emerged as revolutionary new platform technologies for a range of applications, from consumer products such as inkjet printer cartridges to lab-on-a-chip diagnostic systems. Recent developments have opened the door to a new set of opportunities for microfluidic systems, in the field of tissue...

    journal_title:Current opinion in biotechnology

    pub_type: 杂志文章,评审


    authors: Inamdar NK,Borenstein JT

    更新日期:2011-10-01 00:00:00

  • Whole genome amplification--applications and advances.

    abstract::The concept of whole genome amplification is something that has arisen in the past few years as the polymerase chain reaction (PCR) has been adapted to replicate regions of genomes that are of biological interest. The applications are many--forensic science, embryonic disease diagnosis, bioterrorism genome detection, ...

    journal_title:Current opinion in biotechnology

    pub_type: 杂志文章,评审


    authors: Hawkins TL,Detter JC,Richardson PM

    更新日期:2002-02-01 00:00:00

  • Edible genetically modified microorganisms and plants for improved health.

    abstract::The development of new strategies for the delivery of vaccine antigens or immune modulators to the mucosal tissue includes innovative approaches such as the use of genetically modified food microorganisms and plants. Even though the 'proof-of-concept' has recently been established for these two systems, key questions ...

    journal_title:Current opinion in biotechnology

    pub_type: 杂志文章,评审


    authors: Mercenier A,Wiedermann U,Breiteneder H

    更新日期:2001-10-01 00:00:00

  • Advances and current limitations in transcript-level control of gene expression.

    abstract::Gene expression control is critical to increase production of recombinant proteins, fine-tune metabolic pathways and reliably express synthetic pathways. The importance of transcriptional control seems to be most important in eukaryotic systems. In this review, we highlight recent developments in the field of transcri...

    journal_title:Current opinion in biotechnology

    pub_type: 杂志文章,评审


    authors: Leavitt JM,Alper HS

    更新日期:2015-08-01 00:00:00

  • Engineering nanoscale protein compartments for synthetic organelles.

    abstract::Advances in metabolic engineering have given rise to the biological production of novel fuels and chemicals, but yields are often low without significant optimization. One generalizable solution is to create a specialized organelle for the sequestration of engineered metabolic pathways. Bacterial microcompartments are...

    journal_title:Current opinion in biotechnology

    pub_type: 杂志文章,评审


    authors: Kim EY,Tullman-Ercek D

    更新日期:2013-08-01 00:00:00

  • Techniques for the experimental investigation of the protein corona.

    abstract::Due to its enormous relevance the corona formation of adsorbed proteins around nanoparticles is widely investigated. A comparison of different experimental techniques is given. Direct measurements of proteins, such as typically performed with mass spectrometry, will be compared with indirect analysis, in which instead...

    journal_title:Current opinion in biotechnology

    pub_type: 杂志文章,评审


    authors: Carrillo-Carrion C,Carril M,Parak WJ

    更新日期:2017-08-01 00:00:00

  • Carbohydrate diversity: synthesis of glycoconjugates and complex carbohydrates.

    abstract::The fundamental role of glycoconjugates in many biological processes is now well appreciated and has intensified the development of innovative and improved synthetic strategies. All areas of synthetic methodology have seen major advances and many complex, highly branched carbohydrates and glycoproteins have been prepa...

    journal_title:Current opinion in biotechnology

    pub_type: 杂志文章,评审


    authors: Hölemann A,Seeberger PH

    更新日期:2004-12-01 00:00:00

  • Towards better understanding of industrial cell factories: novel approaches for 13C metabolic flux analysis in complex nutrient environments.

    abstract::The quantification of intracellular fluxes via 13C metabolic flux analysis has become one of the major techniques to support systems-based metabolic engineering of industrial production hosts. Commonly, 13C studies are conducted using minimal media, however, a great variety of industrial processes rely on complex medi...

    journal_title:Current opinion in biotechnology

    pub_type: 杂志文章,评审


    authors: Schwechheimer SK,Becker J,Wittmann C

    更新日期:2018-12-01 00:00:00