Designer microbes for biosynthesis.

Abstract:

:Microbes have long been adapted for the biosynthetic production of useful compounds. There is increasing demand for the rapid and cheap microbial production of diverse molecules in an industrial setting. Microbes can now be designed and engineered for a particular biosynthetic purpose, thanks to recent developments in genome sequencing, metabolic engineering, and synthetic biology. Advanced tools exist for the genetic manipulation of microbes to create novel metabolic circuits, making new products accessible. Metabolic processes can be optimized to increase yield and balance pathway flux. Progress is being made towards the design and creation of fully synthetic microbes for biosynthetic purposes. Together, these emerging technologies will facilitate the production of designer microbes for biosynthesis.

journal_name

Curr Opin Biotechnol

authors

Quin MB,Schmidt-Dannert C

doi

10.1016/j.copbio.2014.02.014

subject

Has Abstract

pub_date

2014-10-01 00:00:00

pages

55-61

eissn

0958-1669

issn

1879-0429

pii

S0958-1669(14)00045-7

journal_volume

29

pub_type

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