DNA nanotechnology with one-dimensional self-assembled nanostructures.

Abstract:

:The information encoded in the base sequence of DNA provides substantial structural and functional information for the instructive self-assembly of one-dimensional (1D) functional DNA nanostructures. The hybridization chain reaction (HCR) and the formation of HCR-stimulated DNAzyme nanochains are presented, as a means to develop amplified DNA sensors and aptasensors. Similarly, the rolling circle amplification (RCA) process is implemented to generate 1D DNA nanochains consisting of constant repeat units being implemented for the amplified sensing (using DNAzymes as repeat units) and for the switchable control of electron transfer at electrodes. 1D DNA nanostructures are used as templates for the programmed positioning of enzymes that enable the activation of enzyme cascades and the biocatalytic growth of metallic nanowires. The future perspectives of the self-assembly mechanisms are discussed.

journal_name

Curr Opin Biotechnol

authors

Wang F,Willner B,Willner I

doi

10.1016/j.copbio.2013.02.005

subject

Has Abstract

pub_date

2013-08-01 00:00:00

pages

562-74

issue

4

eissn

0958-1669

issn

1879-0429

pii

S0958-1669(13)00019-0

journal_volume

24

pub_type

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