Abstract：
:Plants synthesize a myriad of secondary metabolites (SMs) that are derived from central or primary metabolism. While these so-called natural products have been targets for plant metabolic engineering attempts for many years, the immense value of manipulating the interface between committed steps in secondary metabolism pathways and those in primary metabolism pathways has only recently emerged. In this review we discuss a few of the major issues that should be taken into consideration in attempts to engineer the primary to secondary metabolism interface. The availability of carbon, nitrogen and sulfur resources will have a major impact on the production of specific classes of primary metabolites (PMs) and consequently on the levels and composition of SMs derived from these PMs. Recent studies have shown that transcription factors associated with the synthesis of a given class of SMs coactivate the expression of genes encoding metabolic enzymes associated with primary pathways that supply precursors to these SMs. In addition, metabolic engineering approaches, which alter post-transcriptional feedback and feedforward regulatory mechanisms of the primary-secondary metabolism interface, have been highly fruitful in Taylormade enhancements of the content of specific beneficial SMs. Lastly, the evolution of pathways of secondary metabolism from pathways of primary metabolism highlights the need to consider cases in which common enzymatic reactions and pathways take place between the two. Taken together, the available information indicates a supercoordinated gene expression networks connecting primary and secondary metabolism in plants, which should be taken into consideration in future attempts to metabolically engineer the various classes of plant SMs.
journal_name
Curr Opin Biotechnoljournal_title
Current opinion in biotechnologyauthors
Aharoni A,Galili Gdoi
10.1016/j.copbio.2010.11.004subject
Has Abstractpub_date
2011-04-01 00:00:00pages
239-44issue
2eissn
0958-1669issn
1879-0429pii
S0958-1669(10)00222-3journal_volume
22pub_type
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