Abstract:
:Fatty acid oxidation pathways are attractive for metabolic engineering purposes due to their cyclic nature as well as their reactions that allow for the selective functionalization of alkyl chains. These characteristics allow for the production of various chemicals, such as alcohols, alkanes, ketones and hydroxyacids, in a wide range of carbon numbers. To this end, the α-, β-, and ω-oxidation pathways have been engineered for use in various hosts. Furthermore, the β-oxidation pathway has been engineered to operate in reverse, resulting in a promising carbon chain elongation platform. This review will describe the recent progress in metabolic engineering strategies for the production of chemicals through these fatty acid oxidation pathways.
journal_name
Curr Opin Biotechnoljournal_title
Current opinion in biotechnologyauthors
Kim S,Cheong S,Chou A,Gonzalez Rdoi
10.1016/j.copbio.2016.07.004subject
Has Abstractpub_date
2016-12-01 00:00:00pages
206-215eissn
0958-1669issn
1879-0429pii
S0958-1669(16)30161-6journal_volume
42pub_type
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journal_title:Current opinion in biotechnology
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journal_title:Current opinion in biotechnology
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journal_title:Current opinion in biotechnology
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journal_title:Current opinion in biotechnology
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journal_title:Current opinion in biotechnology
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journal_title:Current opinion in biotechnology
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journal_title:Current opinion in biotechnology
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journal_title:Current opinion in biotechnology
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