Abstract:
:Antibacterial strategies targeting bacterial adhesion to substrates are considered a valuable alternative to traditional antibiotic therapy, in view of the great advantage they bring in combating the infectious process at the very early stage without selecting for drug resistant cells. Amongst bioactive compounds with activity against bacterial adhesion, several are found in natural food and beverages, such as cranberry, tea, coffee, wine and milk. For the analysis of their anti-infective potential, successful experimental models can be conducted using different substrates from the oral cavity. Studies conducted so far in this field allowed the discovery of a variety of anti-adhesive fractions and compounds proven to be effective against bacterial traits involved in the development of oral pathologies such as caries and gingivitis/periodontitis. Discovering new anti-adhesive compounds from natural products, unravelling and testing their prophylactic and therapeutic values, and improving their use in the general population are promising new frontiers in the global fight against human infectious diseases.
journal_name
Curr Opin Biotechnoljournal_title
Current opinion in biotechnologyauthors
Signoretto C,Canepari P,Stauder M,Vezzulli L,Pruzzo Cdoi
10.1016/j.copbio.2011.08.006subject
Has Abstractpub_date
2012-04-01 00:00:00pages
160-7issue
2eissn
0958-1669issn
1879-0429pii
S0958-1669(11)00674-4journal_volume
23pub_type
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