当前位置： SCI文献检索 > Stem Cell Research期刊下所有文献 > Establishment of TUSMi007-A, an induced pluripotent stem cell (iPSC) line from an 83-year old Chinese Han patient with Alzheimer's disease (AD).

Establishment of TUSMi007-A, an induced pluripotent stem cell (iPSC) line from an 83-year old Chinese Han patient with Alzheimer's disease (AD).

Abstract：

:An 83-year old Alzheimer's disease (AD) male patient donated his Peripheral blood mononuclear cells (PBMC). The non-integrating episomal vector system used to reprogram PBMCs with the human OKSM transcription factors. The pluripotency of transgene-free iPSCs was confirmed by immunocytochemistry for pluripotency markers and by the ability of the iPSCs to differentiate spontaneously into 3 germ layers in vitro. In addition, the iPSC line displayed a normal karyotype. Our model might offer a good platform to further study the pathological mechanisms, to identify early biomarkers, and also for drug testing studies in AD.

journal_name

Stem Cell Res

journal_title

Stem cell research

authors

Wang Y,Zhang J,Lei Y,Zhao J

doi

10.1016/j.scr.2018.11.008

subject

Has Abstract

pub_date

2018-12-01 00:00:00

pages

265-268

eissn

1873-5061

issn

1876-7753

pii

S1873-5061(18)30277-0

journal_volume

33

pub_type

杂志文章

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