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Generation of four postmortem dura-derived iPS cell lines from four control individuals with genotypic and brain-region-specific transcriptomic data available through the BrainSEQ consortium.

Abstract：

:In this study, we established induced pluripotent stem (iPS) cell lines from postmortem dura-derived fibroblasts of four control individuals with low polygenic risk score for psychiatric disorders including schizophrenia and bipolar disorder. The fibroblasts were reprogrammed into iPS cells using episomal vectors carrying OCT3/4, SOX2, KLF4, L-Myc, LIN28 and shRNA-p53. All iPS cell lines showed the same genotype with parental postmortem brain tissues, expressed pluripotency markers, and exhibited the differentiation potency into three embryonic germ layers.

journal_name

Stem Cell Res

journal_title

Stem cell research

authors

Sawada T,Benjamin KJM,Brandtjen AC,Tietze E,Allen SJ,Paquola ACM,Kleinman JE,Hyde TM,Erwin JA

doi

10.1016/j.scr.2020.101806

subject

Has Abstract

pub_date

2020-07-01 00:00:00

pages

101806

eissn

1873-5061

issn

1876-7753

pii

S1873-5061(20)30108-2

journal_volume

46

pub_type

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