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Lymphoblast-derived integration-free iPSC lines from a female and male Alzheimer's disease patient expressing different copy numbers of a coding CNV in the Alzheimer risk gene CR1.

Abstract：

:Human lymphoblast cells from a female and male patient diagnosed with Alzheimer's disease (AD) with different genotypes of a functional copy number variation (CNV) in the AD risk gene CR1 were used to generate integration-free induced pluripotent stem cells (iPSCs) employing episomal plasmids expressing OCT4, SOX2, NANOG, LIN28, c-MYC and L-MYC. The iPSCs retained the CR1 CNV, and comparative transcriptome analyses with the human embryonic stem cell line H1 revealed a Pearson correlation of 0.956 for AD1-CR10 and 0.908 for AD1-CR14.

journal_name

Stem Cell Res

journal_title

Stem cell research

authors

Schröter F,Sleegers K,Van Cauwenberghe C,Bohndorf M,Wruck W,Van Broeckhoven C,Adjaye J

doi

10.1016/j.scr.2016.10.003

subject

Has Abstract

pub_date

2016-11-01 00:00:00

pages

560-563

issue

3

eissn

1873-5061

issn

1876-7753

pii

S1873-5061(16)30165-9

journal_volume

17

pub_type

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