Abstract:
:Haploidentical hematopoietic stem-cell transplantation (haplo-HSCT) is associated with an increased risk of graft failure and severe graft-versus-host disease (GVHD). Mesenchymal stromal cells (MSCs) have been shown to support in vivo normal hematopoiesis and to display potent immunesuppressive effects. We cotransplanted the culture-expanded third-party donor-derived umbilical cord MSCs (UC-MSCs) in 21 young people with severe aplastic anemia (SAA) undergoing haplo-HSCT without T-cell-depleted. We observed that all patients had sustained hematopoietic engraftment without any adverse UC-MSC infusion-related events. Furthermore, we did not observe any increase in severe aGVHD. These data suggest that UC-MSCs, possibly thanks to their potent immunosuppressive effect on allo-reactive host T lymphocytes escaping the preparative regimen, reduce the risk of graft failure and severe GVHD in haplo-HSCT.
journal_name
Stem Cell Resjournal_title
Stem cell researchauthors
Wu Y,Cao Y,Li X,Xu L,Wang Z,Liu P,Yan P,Liu Z,Wang J,Jiang S,Wu X,Gao C,Da W,Han Zdoi
10.1016/j.scr.2013.10.001subject
Has Abstractpub_date
2014-01-01 00:00:00pages
132-8issue
1eissn
1873-5061issn
1876-7753pii
S1873-5061(13)00143-8journal_volume
12pub_type
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