当前位置： SCI文献检索 > Stem Cell Research期刊下所有文献 > The Sirt1 activator SRT3025 expands hematopoietic stem and progenitor cells and improves hematopoiesis in Fanconi anemia mice.

The Sirt1 activator SRT3025 expands hematopoietic stem and progenitor cells and improves hematopoiesis in Fanconi anemia mice.

Abstract：

:Fanconi anemia is a genetic bone marrow failure syndrome. The current treatment options are suboptimal and do not prevent the eventual onset of aplastic anemia requiring bone marrow transplantation. We previously showed that resveratrol, an antioxidant and an activator of the protein deacetylase Sirt1, enhanced hematopoiesis in Fancd2 mutant mice and improved the impaired stem cell quiescence observed in this disease. Given that Sirt1 is important for the function of hematopoietic stem cells, we hypothesized that Sirt1 activation may improve hematopoiesis. Indeed, Fancd2(-/-) mice and wild-type mice treated with the selective Sirt1 activator SRT3025 had increased numbers of hematopoietic stem and progenitor cells, platelets and white blood cells. SRT3025 was also protective against acetaldehyde-induced hematopoietic damage. Unlike resveratrol, however, SRT3025 did not affect stem cell quiescence, suggesting distinct mechanisms of action. Conditional deletion of Sirt1 in hematopoietic cells did not abrogate the beneficial effects of SRT3025, indicating that the drug did not act by directly stimulating Sirt1 in stem cells, but must be acting indirectly via extra-hematopoietic effects. RNA-Seq transcriptome analysis revealed the down-regulation of Egr1-p21 expression, providing a potential mechanism for improved hematopoiesis. Overall, our data indicate that SRT3025 or related compounds may be beneficial in Fanconi anemia and other bone marrow failure syndromes.

journal_name

Stem Cell Res

journal_title

Stem cell research

authors

Zhang QS,Deater M,Schubert K,Marquez-Loza L,Pelz C,Sinclair DA,Grompe M

doi

10.1016/j.scr.2015.05.007

subject

Has Abstract

pub_date

2015-07-01 00:00:00

pages

130-40

issue

1

eissn

1873-5061

issn

1876-7753

pii

S1873-5061(15)00066-5

journal_volume

15

pub_type

杂志文章

相关文献

Stem Cell Research文献大全
  • The role of nuclear receptors in the differentiation of oligodendrocyte precursor cells derived from fetal and adult neural stem cells.

    abstract：:Oligodendrocyte precursor cells (OPCs) differentiation from multipotent neural stem cells (NSCs) into mature oligodendrocytes is driven by thyroid hormone and mediated by thyroid hormone receptors (TRs). We show that several nuclear receptors display strong changes in expression levels between fetal and adult NSCs, wi...

    journal_title：Stem cell research

    pub_type： 杂志文章

    doi：10.1016/j.scr.2019.101443

    authors： Baldassarro VA,Krężel W,Fernández M,Schuhbaur B,Giardino L,Calzà L

    更新日期：2019-05-01 00:00:00

  • Comparative transcriptome analysis in induced neural stem cells reveals defined neural cell identities in vitro and after transplantation into the adult rodent brain.

    abstract：:Reprogramming technology enables the production of neural progenitor cells (NPCs) from somatic cells by direct transdifferentiation. However, little is known on how neural programs in these induced neural stem cells (iNSCs) differ from those of alternative stem cell populations in vitro and in vivo. Here, we performed...

    journal_title：Stem cell research

    pub_type： 杂志文章

    doi：10.1016/j.scr.2016.04.015

    authors： Hallmann AL,Araúzo-Bravo MJ,Zerfass C,Senner V,Ehrlich M,Psathaki OE,Han DW,Tapia N,Zaehres H,Schöler HR,Kuhlmann T,Hargus G

    更新日期：2016-05-01 00:00:00

  • Generation of KCL017 research grade human embryonic stem cell line carrying a mutation in VHL gene.

    abstract：:The KCL017 human embryonic stem cell line was derived from an embryo donated for research that carried an autosomal dominant mutation affecting splicing site of the VHL gene encoding von Hippel-Lindau tumor suppressor E3 ubiquitin protein ligase (676+3A>T). The ICM was isolated using laser microsurgery and plated on γ...

    journal_title：Stem cell research

    pub_type： 杂志文章

    doi：10.1016/j.scr.2016.01.013

    authors： Hewitson H,Wood V,Kadeva N,Cornwell G,Codognotto S,Stephenson E,Ilic D

    更新日期：2016-03-01 00:00:00

  • Mesenchymal stem cells can improve anal pressures after anal sphincter injury.

    abstract：OBJECTIVE:Fecal incontinence reduces the quality of life of many women but has no long-term cure. Research on mesenchymal stem cell (MSC)-based therapies has shown promising results. The primary aim of this study was to evaluate functional recovery after treatment with MSCs in two animal models of anal sphincter injury...

    journal_title：Stem cell research

    pub_type： 杂志文章

    doi：10.1016/j.scr.2012.10.002

    authors： Salcedo L,Mayorga M,Damaser M,Balog B,Butler R,Penn M,Zutshi M

    更新日期：2013-01-01 00:00:00

  • Cells with surface expression of CD133highCD71low are enriched for tripotent colony-forming progenitor cells in the adult murine pancreas.

    abstract：:Progenitor cells in the adult pancreas are potential sources of endocrine beta cells for treating type 1 diabetes. Previously, we identified tri-potent progenitor cells in the adult (2-4month-old) murine pancreas that were capable of self-renewal and differentiation into duct, acinar, and endocrine cells in vitro. The...

    journal_title：Stem cell research

    pub_type： 杂志文章

    doi：10.1016/j.scr.2015.11.015

    authors： Jin L,Gao D,Feng T,Tremblay JR,Ghazalli N,Luo A,Rawson J,Quijano JC,Chai J,Wedeken L,Hsu J,LeBon J,Walker S,Shih HP,Mahdavi A,Tirrell DA,Riggs AD,Ku HT

    更新日期：2016-01-01 00:00:00

  • Generation of induced pluripotent stem cells-derived hepatocyte-like cells for ex vivo gene therapy of primary hyperoxaluria type 1.

    abstract：:Primary hyperoxaluria type 1 (PH1) is a rare autosomal recessive disorder of the liver metabolism due to functional deficiency of the peroxisomal enzyme alanine:glyoxylate aminotransferase (AGT). AGT deficiency results in overproduction of oxalate which complexes with calcium to form insoluble calcium-oxalate salts in...

    journal_title：Stem cell research

    pub_type： 杂志文章

    doi：10.1016/j.scr.2019.101467

    authors： Estève J,Blouin JM,Lalanne M,Azzi-Martin L,Dubus P,Bidet A,Harambat J,Llanas B,Moranvillier I,Bedel A,Moreau-Gaudry F,Richard E

    更新日期：2019-07-01 00:00:00

  • Generation of induced pluripotent stem cells (iPSCs) from an infant with Pompe disease carrying with compound mutations of R608X and E888X in GAA gene.

    abstract：:Induced pluripotent stem cells (iPSCs) were generated from peripheral blood mononuclear cells (PBMCs) isolated from the peripheral blood of a five months-old boy with glycogen storage disease type II(GSD II, also known as Pompe disease, PD) carries compound mutations R608X E888X in GAA gene. PBMCs were reprogrammed us...

    journal_title：Stem cell research

    pub_type： 杂志文章

    doi：10.1016/j.scr.2019.101621

    authors： Zhang Y,Li A,Wang J,Wang G,Wang D

    更新日期：2019-12-01 00:00:00

  • Generation of integration-free induced pluripotent stem cells from a patient with spina bifida.

    abstract：:A skin biopsy was obtained from a 14-year-old female patient with a history of Myelomeningocele. Dermal fibroblasts were isolated and reprogrammed with Sendai virus (SeV) vectors encoding OCT3/4, SOX2, KLF4, and c-MYC. The generated induced Pluripotent Stem Cell (iPSC) clones NTDi4_09A were free of genomically integra...

    journal_title：Stem cell research

    pub_type： 杂志文章

    doi：10.1016/j.scr.2018.05.007

    authors： Wang H,Zhao S,Finnell RH,George T,Cooney AJ

    更新日期：2018-08-01 00:00:00

  • Glycosaminoglycan mimetic improves enrichment and cell functions of human endothelial progenitor cell colonies.

    abstract：:Human circulating endothelial progenitor cells isolated from peripheral blood generate in culture cells with features of endothelial cells named late-outgrowth endothelial colony-forming cells (ECFC). In adult blood, ECFC display a constant quantitative and qualitative decline during life span. Even after expansion, i...

    journal_title：Stem cell research

    pub_type： 杂志文章

    doi：10.1016/j.scr.2014.03.001

    authors： Chevalier F,Lavergne M,Negroni E,Ferratge S,Carpentier G,Gilbert-Sirieix M,Siñeriz F,Uzan G,Albanese P

    更新日期：2014-05-01 00:00:00

  • Transgene expression in various organs post BM-HSC transplantation.

    abstract：:Gene therapy mediated by bone marrow-derived hematopoietic stem cells (BM-HSC) has been widely used in treating genetic deficiencies in both pre-clinical and clinical settings. Using mitotically inactive cell-targeting lentivirus with separate promoters for our gene of interest (the murine MHC class II (MHCII) chapero...

    journal_title：Stem cell research

    pub_type： 杂志文章

    doi：10.1016/j.scr.2013.10.010

    authors： Wang N,Rajasekaran N,Hou T,Mellins ED

    更新日期：2014-01-01 00:00:00

  • The granulocyte macrophage-colony stimulating factor surface modified MB49 bladder cancer stem cells vaccine against metastatic bladder cancer.

    abstract：:The MB49 bladder cancer cell vaccine was effective against bladder cancer in the mice model in previous studies. However, part of the tumors regrew as the vaccine could not eliminate the cancer stem cells (CSCs). MB49 bladder cancer stem cells (MCSCs) were isolated by a combination of the limited dilution method and t...

    journal_title：Stem cell research

    pub_type： 杂志文章

    doi：10.1016/j.scr.2014.04.006

    authors： Zhu YT,Zhao Z,Fu XY,Luo Y,Lei CY,Chen W,Li F,Pang SY,Chen SS,Tan WL

    更新日期：2014-07-01 00:00:00

  • Cotransplantation of haploidentical hematopoietic and umbilical cord mesenchymal stem cells for severe aplastic anemia: successful engraftment and mild GVHD.

    abstract：:Haploidentical hematopoietic stem-cell transplantation (haplo-HSCT) is associated with an increased risk of graft failure and severe graft-versus-host disease (GVHD). Mesenchymal stromal cells (MSCs) have been shown to support in vivo normal hematopoiesis and to display potent immunesuppressive effects. We cotransplan...

    journal_title：Stem cell research

    pub_type： 杂志文章

    doi：10.1016/j.scr.2013.10.001

    authors： Wu Y,Cao Y,Li X,Xu L,Wang Z,Liu P,Yan P,Liu Z,Wang J,Jiang S,Wu X,Gao C,Da W,Han Z

    更新日期：2014-01-01 00:00:00

  • Insulin-like growth factor 1 can promote the osteogenic differentiation and osteogenesis of stem cells from apical papilla.

    abstract：:Insulin-like growth factor 1 (IGF-1) plays an important role in the regulation of tooth root development, and stem cells from apical papilla (SCAPs) are responsible for the formation of root pulp and dentin. To date, it remains unclear whether IGF-1 can regulate the function of SCAPs. In this study, SCAPs were isolate...

    journal_title：Stem cell research

    pub_type： 杂志文章

    doi：10.1016/j.scr.2011.12.005

    authors： Wang S,Mu J,Fan Z,Yu Y,Yan M,Lei G,Tang C,Wang Z,Zheng Y,Yu J,Zhang G

    更新日期：2012-05-01 00:00:00

  • Inhibition of ERK1/2 prevents neural and mesendodermal differentiation and promotes human embryonic stem cell self-renewal.

    abstract：:Extracellular signal-regulated kinases (ERKs) have many important functions during embryogenesis. However, their role in embryonic stem (ES) cells is controversial. Previous studies reported that, in contrast to mouse ES cells, human ES cells differentiate if ERK1/2 is inhibited. We reexamined the role of ERK1/2 in hu...

    journal_title：Stem cell research

    pub_type： 杂志文章

    doi：10.1016/j.scr.2010.06.002

    authors： Na J,Furue MK,Andrews PW

    更新日期：2010-09-01 00:00:00

  • Generation of an integration-free iPSC line(SYSUi001-A) from a sporadic Alzheimer's disease patient.

    abstract：:Human iPSC line, iPSC-ADM01(SYSUi001-A), was generated from a 70-year-old male patient with sporadic Alzheimer's disease, using non-integrative reprogramming method. This cell line shows pluripotency both in vitro and in vivo, and has a normal karyotype. ...

    journal_title：Stem cell research

    pub_type： 杂志文章

    doi：10.1016/j.scr.2018.101375

    authors： Wei R,Han H,Ye M,He L,Lei Q,Zhou T,Cai X,Li Z

    更新日期：2019-03-01 00:00:00

  • Generation of three iPSC lines (IAIi002, IAIi004, IAIi003) from Rubinstein-Taybi syndrome 1 patients carrying CREBBP non sense c.4435G>T, p.(Gly1479*) and c.3474G>A, p.(Trp1158*) and missense c.4627G>T, p.(Asp1543Tyr) mutations.

    abstract：:Rubinstein-Taybi syndrome (RSTS) is a neurodevelopmental disorder characterized by growth retardation, skeletal anomalies and intellectual disability, caused by heterozygous mutations in either CREBBP (RSTS1) or EP300 (RSTS2) genes. We characterized 3 iPSC lines generated by Sendai from blood of RSTS1 patients with un...

    journal_title：Stem cell research

    pub_type： 杂志文章

    doi：10.1016/j.scr.2019.101553

    authors： Alari V,Russo S,Rovina D,Garzo M,Crippa M,Calzari L,Scalera C,Concolino D,Castiglioni E,Giardino D,Prosperi E,Finelli P,Gervasini C,Gowran A,Larizza L

    更新日期：2019-10-01 00:00:00

  • Generation of induced pluripotent stem cell (iPSC) line from a patient with triple negative breast cancer with hereditary exon 17 deletion of BRCA1 gene.

    abstract：:BRCA1 germline mutation confers hereditary predisposition for breast and ovarian cancer. To understand the physiopathology of mammary and ovarian epithelial cancer transformation, and to identify early driver molecular events, we have generated an iPSC line from a patient carrying a germline exon 17 deletion in BRCA1 ...

    journal_title：Stem cell research

    pub_type： 杂志文章

    doi：10.1016/j.scr.2017.09.003

    authors： Griscelli F,Oudrhiri N,Feraud O,Divers D,Portier L,Turhan AG,Bennaceur Griscelli A

    更新日期：2017-10-01 00:00:00

  • One-step generation of murine embryonic stem cell-derived mesoderm progenitors and chondrocytes in a serum-free monolayer differentiation system.

    abstract：:Cartilage defects have limited capacity for repair and are often replaced by fibrocartilage with inferior mechanical properties. To overcome the limitations of artificial joint replacement, high-throughput screens (HTS) could be developed to identify molecules that stimulate differentiation and/or proliferation of art...

    journal_title：Stem cell research

    pub_type： 杂志文章

    doi：10.1016/j.scr.2010.08.007

    authors： Waese EY,Stanford WL

    更新日期：2011-01-01 00:00:00

  • Generation of induced pluripotent stem cell line (XDCMHi001-A) from an Ankylosing spondylitis patient with JAK2 mutation.

    abstract：:Heredity is the major factor contributing to the susceptibility to ankylosing spondylitis(AS). Janus kinase 2 (JAK2) has been associated with AS. Urine-derived cells from an AS patient with JAK2 mutation were used to generate induced pluripotent stem cells (iPSCs) with five episomal iPSC reprogramming vectors (pCXLE-h...

    journal_title：Stem cell research

    pub_type： 杂志文章

    doi：10.1016/j.scr.2020.101788

    authors： Hu J,Ren W,Qiu W,Lv J,Zhang C,Xu C,DU W,Wu M,Wang J,Quan R

    更新日期：2020-05-01 00:00:00

  • Feeder-independent derivation of induced-pluripotent stem cells from peripheral blood endothelial progenitor cells.

    abstract：:Induced-pluripotent stem cells (iPSCs) are a potential alternative cell source in regenerative medicine, which includes the use of differentiated iPSCs for cell therapies to treat coronary artery and/or peripheral arterial diseases. Late-outgrowth endothelial progenitor cells (late-EPCs) are a unique primary cell pres...

    journal_title：Stem cell research

    pub_type： 杂志文章

    doi：10.1016/j.scr.2012.11.006

    authors： Chang WY,Lavoie JR,Kwon SY,Chen Z,Manias JL,Behbahani J,Ling V,Kandel RA,Stewart DJ,Stanford WL

    更新日期：2013-03-01 00:00:00

  • Stage-specific roles of FGF2 signaling in human neural development.

    abstract：:This study elucidated the stage-specific roles of FGF2 signaling during neural development using in-vitro human embryonic stem cell-based developmental modeling. We found that the dysregulation of FGF2 signaling prior to the onset of neural induction resulted in the malformation of neural rosettes (a neural tube-like ...

    journal_title：Stem cell research

    pub_type： 杂志文章

    doi：10.1016/j.scr.2016.08.012

    authors： Grabiec M,Hříbková H,Vařecha M,Střítecká D,Hampl A,Dvořák P,Sun YM

    更新日期：2016-09-01 00:00:00

  • Exosomes from 3D culture of marrow stem cells enhances endothelial cell proliferation, migration, and angiogenesis via activation of the HMGB1/AKT pathway.

    abstract：BACKGROUND:Angiogenesis is an essential step in tissue engineering. MSC exosomes play an important role in angiogenesis. Functional biomolecules in exosomes vested by the culture microenvironment can be transferred to recipient cells and affects their effect. 3D culture can improve the proliferation and activity of MSC...

    journal_title：Stem cell research

    pub_type： 杂志文章

    doi：10.1016/j.scr.2020.102122

    authors： Gao W,Liang T,He R,Ren J,Yao H,Wang K,Zhu L,Xu Y

    更新日期：2020-12-10 00:00:00

  • Establishment of induced pluripotent stem cell line CSUASOi004-A by reprogramming peripheral blood mononuclear cells of a PRPF6-related dominant retinitis pigmentosa patient.

    abstract：:We have established the patient-specific induced pluripotent stem (iPS) cell line CSUASOi004-A by using peripheral blood mononuclear cells (PBMCs) of a retinitis pigmentosa (RP) patient with a PRPF6 gene mutation (c.G2699A:p.R900H). CSUASOi004-A was established by a non-integrative method with four episomal plasmids c...

    journal_title：Stem cell research

    pub_type： 杂志文章

    doi：10.1016/j.scr.2020.101793

    authors： Zhou Y,Jing Y,Mao S,Liu J,Cui Z,Wang Y,Chen J,Chan HF,Tang S,Chen J

    更新日期：2020-05-01 00:00:00

  • Derivation of the clinical grade human embryonic stem cell line RCe019-A (RC-15).

    abstract：:The human embryonic stem cell line RCe019-A (RC-15) was derived under quality assured compliance with UK regulation, European Union Directives and International guidance for tissue procurement, processing and storage according to Good Manufacturing Practice (GMP) standards. The cell line was derived from a cleavage st...

    journal_title：Stem cell research

    pub_type： 杂志文章

    doi：10.1016/j.scr.2016.04.003

    authors： De Sousa PA,Tye BJ,Bruce K,Dand P,Russell G,Collins DM,Greenshields A,McDonald K,Bradburn H,Laurie A,Downie JM,Bateman M,Courtney A

    更新日期：2016-05-01 00:00:00

  • Stem cell passage affects directional migration of stem cells in electrotaxis.

    abstract：:Stem cells can differentiate into various body tissues and organs and thus are considered as promising tools for cell therapy and tissue engineering. Early passage stem cells have high differentiation ability compared to late passage stem cells. Thus, it is important to use early passage stem cells in cell therapy. He...

    journal_title：Stem cell research

    pub_type： 杂志文章

    doi：10.1016/j.scr.2019.101475

    authors： Hong SH,Lee MH,Koo MA,Seon GM,Park YJ,Kim D,Park JC

    更新日期：2019-07-01 00:00:00

  • Establishment of human induced pluripotent stem cell line (CPGHi002-A) from a 10-month-old female patient with DDOD syndrome carrying a heterozygous c.1516 C > T mutation in ATP6V1B2.

    abstract：:Dominant deafness-onychodystrophy (DDOD) syndrome is a rare, autosomal dominant inherited disorder with no concrete therapies in human. We previously identified c.1516 C > T (p.Arg506*) in ATP6V1B2 as cause of DDOD syndrome, accounting for all cases of this genetic disorder. The induced pluripotent stem cell (iPSC) li...

    journal_title：Stem cell research

    pub_type： 杂志文章

    doi：10.1016/j.scr.2020.101986

    authors： Gao X,Qiu SW,Feng ML,Huang SS,Kang DY,Han MY,Dai P,Yuan YY

    更新日期：2020-10-01 00:00:00

  • The contribution of human/non-human animal chimeras to stem cell research.

    abstract：:Chimeric animals are made up of cells from two separate zygotes. Human/non-human animal chimeras have been used for a number of research purposes, including human disease modeling. Pluripotent stem cell (PSC) research has relied upon the chimera approach to examine the developmental potential of stem cells, to determi...

    journal_title：Stem cell research

    pub_type： 杂志文章,评审

    doi：10.1016/j.scr.2017.09.005

    authors： Levine S,Grabel L

    更新日期：2017-10-01 00:00:00

  • Cell surface markers for the identification and study of human naive pluripotent stem cells.

    abstract：:Characterisation of mouse pluripotent stem cells has revealed two distinct pluripotent states, naive and primed, that maintain characteristics of the pre and post implanted epiblast respectively. Recent studies have developed several culture systems that seek to recapitulate the naive phenomenon in human pluripotent s...

    journal_title：Stem cell research

    pub_type： 杂志文章,评审

    doi：10.1016/j.scr.2017.11.017

    authors： Trusler O,Huang Z,Goodwin J,Laslett AL

    更新日期：2018-01-01 00:00:00

  • ROCK inhibitor increases proacinar cells in adult salivary gland organoids.

    abstract：:Salisphere-derived adult epithelial cells have been used to improve saliva production of irradiated mouse salivary glands. Importantly, optimization of the cellular composition of salispheres could improve their regenerative capabilities. The Rho Kinase (ROCK) inhibitor, Y27632, has been used to increase the prolifera...

    journal_title：Stem cell research

    pub_type： 杂志文章

    doi：10.1016/j.scr.2019.101608

    authors： Koslow M,O'Keefe KJ,Hosseini ZF,Nelson DA,Larsen M

    更新日期：2019-12-01 00:00:00

  • Establishment of an induced pluripotent stem cell line (FDEENTi001-A) from a patient with pathological myopia.

    abstract：:Pathological myopia (PM) is a retinal degenerative disease with an increasing prevalence in Asia. The peripheral blood mononuclear cells (PBMCs) from a patient with PM were successfully reprogrammed to induced pluripotent stem cells (iPSCs) using integration-free method, Sendai viral (SeV) vectors expressing OCT4, SOX...

    journal_title：Stem cell research

    pub_type： 杂志文章

    doi：10.1016/j.scr.2018.101369

    authors： Bai X,Yang X,Cheng Y,Chen L

    更新日期：2019-01-01 00:00:00