Abstract:
:Peripheral blood mononuclear cells for reprogramming in this work were donated by a girl with clinically and genetically diagnosed multiminicore disease harboring compound heterozygote mutations of RYR1 gene. Induced pluripotent stem cells (iPSCs) were obtained by non-integrating episomal vectors containing OCT4, SOX2, KLF4, BCL-XL and c-MYC. The iPSC line (SDQLCHi025-A) presented pluripotent cell morphology, high mRNA levels of pluripotency markers, differentiation potential in vitro, a normal karyotype, and carrying RYR1 gene mutations.
journal_name
Stem Cell Resjournal_title
Stem cell researchauthors
Zhang H,Ma Y,Lv Y,Wan Y,Zhao Q,Gai Z,Liu Ydoi
10.1016/j.scr.2020.101775subject
Has Abstractpub_date
2020-05-01 00:00:00pages
101775eissn
1873-5061issn
1876-7753pii
S1873-5061(20)30079-9journal_volume
45pub_type
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