Current perspectives of cancer-associated fibroblast in therapeutic resistance: potential mechanism and future strategy.

abstract：:Glioblastoma (GBM) is the most aggressive type of glioma. Temozolomide (TMZ) is currently the drug of choice used for post-operative chemotherapy of GBM. However, the presence of intrinsic and acquired resistance hinders the success of chemotherapy. To understand the TMZ resistant mechanisms in glioma, we investigated...

journal_title：Cell biology and toxicology

authors： Tomar VS,Patil V,Somasundaram K

更新日期：2020-06-01 00:00:00

abstract：:Sea urchin embryos and larvae represent suitable model systems on where to investigate the effects of heavy metals on development and cell viability. Here, we tested the toxic effects of low (10(-12 )M), medium (10(-9 )M), and high (10(-6 )M) cadmium chloride concentrations, mimicking unpolluted, moderately and highly...

journal_title：Cell biology and toxicology

authors： Filosto S,Roccheri MC,Bonaventura R,Matranga V

更新日期：2008-12-01 00:00:00

abstract：:The mesothelial cells (MCs) play an important role in the morpho-functional alterations of the peritoneal membrane (PM) undergoing peritoneal dialysis (PD). MCs, through the epithelial-mesenchymal transition process (EMT), progressively acquire a myofibroblast-like phenotype, promoting peritoneal fibrosis (PF) and fai...

journal_title：Cell biology and toxicology

authors： Lupinacci S,Perri A,Toteda G,Vizza D,Puoci F,Parisi OI,Giordano F,Lofaro D,La Russa A,Bonofiglio M,Bonofiglio R

更新日期：2019-04-01 00:00:00

abstract：:Two human hepatoma cell lines, KYN-2 and Mz-Hep-1 were characterized in terms of glucuronidation capacity and inducibility of cytochrome P4501A1/1A2 and several UDP-glucuronosyltransferases (UGTs). Cytochrome P4501A1/1A2 activity was measured using 7-ethoxyresorufin and that of UGTs with 16 different substrates. The e...

journal_title：Cell biology and toxicology

authors： Abid A,Sabolovic N,Magdalou J

更新日期：1996-04-01 00:00:00

abstract：:A useful approach for constructing dose-response relationships and for studying the underlying mechanisms by which a xenobiotic agent enhances airway reactivity is to measure the response of an isolated airway following ex vivo exposure to a pollutant. We have in this way determined the dose-response relationship betw...

journal_title：Cell biology and toxicology

authors： Roux E,Ouedraogo N,Hyvelin JM,Savineau JP,Marthan R

更新日期：2002-01-01 00:00:00

abstract：:Clinical tests of gene sequence, structure, and function are to predict, diagnose, monitor, and prognose human disease-specific phenomes, characters severities, durations, stages, and responses to therapy. The concept and content of gene tests for clinical application mainly include chromosome/chromatins, DNA, and RNA...

journal_title：Cell biology and toxicology

authors： Wu D,Cheng Y,Wang X,CSGT group.

更新日期：2019-04-01 00:00:00

abstract：:Human tumor cells have properties in vitro or in surrogate hosts that are distinct from those of normal cells, such as immortality, anchorage independence, and tumor formation in nude mice. However, different cells from individual tumors may exhibit some, but not all of these features. In previous years, human tumor c...

journal_title：Cell biology and toxicology

authors： Lee H,Li D,Prior T,Casto BC,Weghorst CM,Shuler CF,Milo GE

更新日期：1997-10-01 00:00:00

abstract：:Ziram, a zinc dithiocarbamate is widely used worldwide as a fungicide in agriculture. In order to investigate ziram-induced changes in macrophage functions and polarization, human monocytes-derived macrophages in culture were treated with ziram at 0.01-10 μmol.L-1 for 4-24 h. To characterize zinc involvement in these ...

journal_title：Cell biology and toxicology

authors： Parny M,Bernad J,Prat M,Salon M,Aubouy A,Bonnafé E,Coste A,Pipy B,Treilhou M

更新日期：2020-07-25 00:00:00

abstract：:In pharmaceutical research, in vitro toxicity tests, for assessing the potential toxicity of new chemical entities are necessary in the early stages of the developmental process, when no information is available about the metabolism or even the target organ toxicity of the compounds to be tested. In vitro specific org...

journal_title：Cell biology and toxicology

authors： Negro GD,Bonato M,Gribaldo L

更新日期：2001-01-01 00:00:00

abstract：:In vitro directional migration of 10T1/2 fibroblasts is partially inhibited by TPA but not by its non-promoting analogues. Other tumor promoters, e.g., phenobarbital, saccharin, and benzoylperoxide had no measurable effect when added in concentrations known to affect in vitro two-step transformation or intercellular c...

journal_title：Cell biology and toxicology

authors： Verschueren H

更新日期：1985-06-01 00:00:00

abstract：:In a comprehensive assessment of genotoxicity, sodium fluoride was evaluated in a battery of cellular tests providing different genetic end points and biotransformation capabilities. The tests included the following: rat hepatocyte primary culture/DNA repair assay, Salmonella typhimurium histidine locus reversion assa...

journal_title：Cell biology and toxicology

authors： Tong CC,McQueen CA,Brat SV,Williams GM

更新日期：1988-06-01 00:00:00

abstract：:The mutation rates of tumor suppressor protein p53 gene (TP53) are high in lung adenocarcinoma and promote the development of acquired drug resistance. The present study evaluated the p53-dependent role in lung cancer cell sensitivity to PI3K-specific inhibitors, PI3K-associated inhibitors, PI3K-non-related inhibitors...

journal_title：Cell biology and toxicology

authors： Hou J,Cao X,Cheng Y,Wang X

更新日期：2020-10-01 00:00:00

abstract：:Rats chronically exposed to acrylonitrile (ACN) have shown a dose-dependent increase in the incidence of astrocytomas in the brain. The mechanism(s) by which ACN induces cancer in rodents has not been established. ACN does not appear to be directly genotoxic in the brain and thus a nongenotoxic mode of action has been...

journal_title：Cell biology and toxicology

authors： Kamendulis LM,Jiang J,Zhang H,deFeijter-Rupp H,Trosko JE,Klaunig JE

更新日期：1999-06-01 00:00:00

abstract：:The nephrotoxic fungal toxins ochratoxin A (OA), ochratoxin B (OB) and citrinin (CIT) are natural contaminants of foods and feeds. While cytotoxicity assays have proven useful for establishing relative toxicity and structure function relationships within groups of fungal toxins, a drawback of in vitro bioassays is the...

journal_title：Cell biology and toxicology

authors： Bondy GS,Armstrong CL

更新日期：1998-10-01 00:00:00

abstract：:Reciprocal interactions between tumor cells and endothelial cells constitute the most important stage of tumor metastasis. There is growing evidence suggesting that beta-estradiol and vitamin D modulate the progression of steroid-sensitive breast cancers. In keeping with those results, the purpose of the study reporte...

journal_title：Cell biology and toxicology

authors： Paduch R,Kandefer-Szerszeń M

更新日期：2005-09-01 00:00:00

abstract：:The culture of rabbit tenocytes could be a useful model in the study of the physiopathology and pharmacotoxicology of tendons. This work was undertaken to examine the in vitro behavior of tenocytes form juvenile rabbit Achilles tendons. We report observations of the morphological and biological characteristics of prim...

journal_title：Cell biology and toxicology

authors： Bernard-Beaubois K,Hecquet C,Houcine O,Hayem G,Adolphe M

更新日期：1997-02-01 00:00:00

abstract：:Magnesium, an essential metal that is important in the normal functioning of DNA, has been shown to interact with some of the toxic heavy metals in respect to biochemical and molecular mechanisms and in altering the tumorigenic process. This study examined the influence of magnesium in combination with nickel and cadm...

journal_title：Cell biology and toxicology

authors： Littlefield NA,Hass BS,James SJ,Poirier LA

更新日期：1994-04-01 00:00:00

abstract：:In previous studies cadmium chloride (CdCl2) nonlethally inhibited Y-1 adrenal mouse adrenal tumour cell 20-dihydroxyprogesterone (20DHP) secretion, affecting unstimulated and stimulated steroidogenic pathway sites differently. We studied CdCl2 effects on unstimulated steroidogenesis using Y-1 cells incubated 0.5 h in...

journal_title：Cell biology and toxicology

authors： Mgbonyebi OP,Smothers CT,Mrotek JJ

更新日期：1994-02-01 00:00:00

abstract：OBJECTIVES:LncRNAs (long noncoding RNAs) have been reported to critically regulate colorectal cancer (CRC). We prospectively investigated effects and mechanisms of lncRNA LINC00858 on regulation of CRC progression. METHODS:Expression of LINC00858 and its target were analyzed by quantitative real-time polymerase chain ...

journal_title：Cell biology and toxicology

authors： Zhan W,Liao X,Chen Z,Li L,Tian T,Yu L,Li R

更新日期：2020-08-01 00:00:00

abstract：:The use of normal adult liver hepatocytes in cell culture for biochemical, toxicological and pharmacological studies has been greatly limited owing to the loss of replicative capacity and differentiated liver function. This is contrary to the ability of the liver to regenerate following injury in vivo. This suggests t...

journal_title：Cell biology and toxicology

authors： Gibson-D'Ambrosio RE,Crowe DL,Shuler CE,D'Ambrosio SM

更新日期：1993-10-01 00:00:00

abstract：:Exposure to compounds with cancer-potentiating effects can contribute to the progression of cancer. Herein we have discovered for the first time that benzophenone-3 (BP-3), a chemical used as sunscreen in various cosmetic products, enhances the ability of lung cancer cells to undergo metastasis. The exposure of the lu...

journal_title：Cell biology and toxicology

authors： Phiboonchaiyanan PP,Busaranon K,Ninsontia C,Chanvorachote P

更新日期：2017-06-01 00:00:00

abstract：:Chrysotile is the predominant type of asbestos used in the United States and thus represents the most important source of exposure to asbestos already in place. While the steepest exposure-response observed for lung cancer has been in workers exposed to chrysotile in textile operations, some argue that chrysotile is l...

journal_title：Cell biology and toxicology

authors： Dement JM

更新日期：1991-01-01 00:00:00

abstract：:To select an insert suitable for human umbilical vein endothelial cell (HUVEC) culture, we compared several available inserts of 0.2 to 0.45 micron porosity: Cellagen (ICN), Transwell-COL (Costar), Millicell-HA and CM (Millipore), Anopore (Nunc), Cyclopore (Falcon) in comparison with a control surface (Thermanox). The...

journal_title：Cell biology and toxicology

authors： Villars F,Conrad V,Rouais F,Lefebvre F,Amédée J,Bordenave L

更新日期：1996-12-01 00:00:00

abstract：:Owing to the excellent antibacterial and antiviral activity, silver nanoparticles have a widespread use in the food and pharmaceutical industries. With the increase in the production and use of the related products, the potential hazard of silver nanoparticles has aroused public attention. The main purpose of this stu...

journal_title：Cell biology and toxicology

authors： Li L,Bi Z,Hu Y,Sun L,Song Y,Chen S,Mo F,Yang J,Wei Y,Wei X

更新日期：2020-05-04 00:00:00

abstract：:The effects of aplysiatoxin and debromoaplysiatoxin on the clonal growth rate, cross-linked envelope formation and plasminogen activator secretion of normal human bronchial epithelial cells were studied. Neither compound was mitogenic over a wide range of concentrations (10(-13) to 10(-7)M). Both aplysiatoxin and debr...

journal_title：Cell biology and toxicology

authors： Willey JC,Moser CE Jr,Harris CC

更新日期：1984-10-01 00:00:00

abstract：:Aldehyde dehydrogenase was measured in primary cultures of hepatocytes obtained with a two-step collagenase perfusion either from human hepatic tissue or from livers of Fisher rats. Basal enzyme activity declines gradually as a function of time in culture, but remains at all times higher when measured with propionalde...

journal_title：Cell biology and toxicology

authors： Marselos M,Strom SC,Michalopoulos G

更新日期：1986-06-01 00:00:00

abstract：:Metolachlor, a commonly used herbicide in the Midwestern USA, functions by inhibiting chlorophyll and protein synthesis in target plants. Herbicide exposure has led to detrimental effects in several organisms, affecting their growth and behavior; however, its mechanism of action in nontarget organisms is not yet clear...

journal_title：Cell biology and toxicology

authors： Lowry DM,Greiner D,Fretheim M,Ubben M,Dhanwada KR

更新日期：2013-08-01 00:00:00

abstract：:Ten compounds representative of diverse classes of chemicals were evaluated for their cytotoxicity and transforming ability to human skin fibroblasts in vitro. Only five of the ten compounds were highly cytotoxic in the 0-100 micrograms/ml range and their order of cytotoxicity was: 2,5-bis(1-aziridinyl)-3,6-bis(carboe...

journal_title：Cell biology and toxicology

authors： Kurian P,Nesnow S,Milo GE

更新日期：1990-04-01 00:00:00

abstract：:A method for the primary culture of rat liver cells on collagen-coated dextran microcarriers is described. Ethoxycoumarin deethylase (EOD) activity 24 hr after inoculation was comparable for liver cells cultured on microcarriers and on collagen-coated dishes. Cells were cultured on microcarriers for up to 48 hr and re...

journal_title：Cell biology and toxicology

authors： Voss JU,Seibert H

更新日期：1991-10-01 00:00:00

abstract：:Based on the reduced expression of ethanol-oxidizing enzymes in human hepatocellular carcinoma (HepG2) cells, we analyzed the role of nonoxidative metabolites in ethanol-induced apoptosis in HepG2 cells. For this purpose, an analysis of volatile metabolites of ethanol using ion-mobility spectrometry and gas chromatogr...

journal_title：Cell biology and toxicology

authors： Castaneda F,Zimmermann D,Nolte J,Baumbach JI

更新日期：2007-11-01 00:00:00