Abstract:
:The effects of aplysiatoxin and debromoaplysiatoxin on the clonal growth rate, cross-linked envelope formation and plasminogen activator secretion of normal human bronchial epithelial cells were studied. Neither compound was mitogenic over a wide range of concentrations (10(-13) to 10(-7)M). Both aplysiatoxin and debromoaplysiatoxin inhibited clonal growth rate with 50% inhibitory concentrations of 3 x 10(-11)M and 10(-10)M, respectively. Both compounds induced the formation of cross-linked envelopes and increased plasminogen activator secretion with equal potency. These data are similar to those previously obtained with 12-O-tetradecanoylphorbol-13-acetate and teleocidin B and suggest that aplysiatoxin and debromoaplysiatoxin induce terminal squamous differentiation in normal human bronchial epithelial cells.
journal_name
Cell Biol Toxicoljournal_title
Cell biology and toxicologyauthors
Willey JC,Moser CE Jr,Harris CCdoi
10.1007/BF00125571subject
Has Abstractpub_date
1984-10-01 00:00:00pages
145-54issue
1eissn
0742-2091issn
1573-6822journal_volume
1pub_type
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