Inducibility of ethoxyresorufin deethylase and UDP-glucuronosyltransferase activities in two human hepatocarcinoma cell lines KYN-2 and Mz-Hep-1.

abstract：:Glioblastoma (GBM) is the most aggressive type of glioma. Temozolomide (TMZ) is currently the drug of choice used for post-operative chemotherapy of GBM. However, the presence of intrinsic and acquired resistance hinders the success of chemotherapy. To understand the TMZ resistant mechanisms in glioma, we investigated...

journal_title：Cell biology and toxicology

authors： Tomar VS,Patil V,Somasundaram K

更新日期：2020-06-01 00:00:00

abstract：:Uranium is a natural radioactive metallic element; its effect on the organism is cumulative, and chronic exposure to this element can induce carcinogenesis. Three cities of the Amazon region-Monte Alegre, Prainha, and Alenquer-in North Brazil, are located in one of the largest uranium mineralization areas of the world...

journal_title：Cell biology and toxicology

authors： Guimarães AC,Antunes LM,Ribeiro HF,dos Santos AK,Cardoso PC,de Lima PL,Seabra AD,Pontes TB,Pessoa C,de Moraes MO,Cavalcanti BC,Sombra CM,Bahia Mde O,Burbano RR

更新日期：2010-10-01 00:00:00

abstract：:The piperidine nitroxides Tempamine and Tempace have been studied for their effect on doxorubicin (DOX) and hydrogen peroxide (H(2)O(2)) cytotoxicity in immortalized B14 cells, a model for neoplastic phenotype. The significance for nitroxide performance of the substituent in position 4 of the piperidine ring was evalu...

journal_title：Cell biology and toxicology

authors： Czepas J,Koceva-Chyła A,Gwoździński K,Jóźwiak Z

更新日期：2008-01-01 00:00:00

abstract：:Quinones are widely distributed in the environment, both as natural products and as pollutants. This paper reports that one of the simplest quinones, 2-methyl-1,4-naphthoquinone (menadione), effectively inhibited apoptosis in the presence of UVA. Menadione suppressed the apoptosis induced by serum depletion and cell d...

journal_title：Cell biology and toxicology

authors： Ibuki Y,Toyooka T,Goto R

更新日期：2006-09-01 00:00:00

abstract：:Microcystin-leucine-arginine (MC-LR) was produced by toxic cyanobacteria, which has been shown to have potent hepatotoxicity. Our previous study has proved that MC-LR were able to promote intrahepatic biliary epithelial cell excessive proliferation. However, the underlying mechanism is not yet entirely clarified. Here...

journal_title：Cell biology and toxicology

authors： Yan M,Gu S,Pan C,Chen Y,Han X

更新日期：2021-01-21 00:00:00

abstract：:Because sodium fluoride (NaF) is widely used for prevention of dental caries, pathobiological effects of NaF were investigated on human oral mucosal fibroblasts. The results showed that NaF was cytotoxic to oral mucosal fibroblasts at concentrations of 4 mmol/L or higher. Exposure of cells to NaF for 2 h also inhibite...

journal_title：Cell biology and toxicology

authors： Jeng JH,Hsieh CC,Lan WH,Chang MC,Lin SK,Hahn LJ,Kuo MY

更新日期：1998-12-01 00:00:00

abstract：:Because of a possible role of astrocytes in trialkyltin-induced neurotoxicity in vivo various studies have been performed using cultures of astrocytes or glioma cells in vitro. With respect to cytotoxic potencies of trialkyltins these studies gave rather divergent results. Therefore the aim of the present study was to...

journal_title：Cell biology and toxicology

authors： Seibert H,Mörchel S,Gülden M

更新日期：2004-09-01 00:00:00

abstract：:The purpose of the study was to determine whether along and in combination melatonin (MLT) and pentoxifylline (PTX) exerted beneficial effects on histopathological changes and changes in oxidant and antioxidant systems in liver caused by CCl4-induced liver toxicity in mice. Mice were randomly divided into six groups: ...

journal_title：Cell biology and toxicology

authors： Noyan T,Kömüroğlu U,Bayram I,Sekeroğlu MR

更新日期：2006-11-01 00:00:00

abstract：:During the last decade, the unbound glutathione content of cultured adherent cells has become a very important biological marker for many pharmacological and toxicological in vitro studies with regard to the protective role of the tripeptide in its reduced form (GSH). However, the literature does not provide extensive...

journal_title：Cell biology and toxicology

authors： Thioudellet C,Oster T,Leroy P,Nicolas A,Wellman M

更新日期：1995-04-01 00:00:00

abstract：:The goal of cancer eradication has been overshadowed despite the continuous improvement in research and generation of novel cancer therapeutic drugs. One of the undeniable existing problems is drug resistance due to which the paradigm of killing all cancer cells is ineffective. Tumor microenvironment plays a crucial r...

journal_title：Cell biology and toxicology

authors： Kadel D,Zhang Y,Sun HR,Zhao Y,Dong QZ,Qin LX

更新日期：2019-10-01 00:00:00

abstract：:Rats chronically exposed to acrylonitrile (ACN) have shown a dose-dependent increase in the incidence of astrocytomas in the brain. The mechanism(s) by which ACN induces cancer in rodents has not been established. ACN does not appear to be directly genotoxic in the brain and thus a nongenotoxic mode of action has been...

journal_title：Cell biology and toxicology

authors： Kamendulis LM,Jiang J,Zhang H,deFeijter-Rupp H,Trosko JE,Klaunig JE

更新日期：1999-06-01 00:00:00

abstract：:The ubiquitin proteasome-proteolytic pathway has emerged as one of the most significant pathways in modulating protein homeostasis under both normal and disease states. The use of proteasome inhibitors (PI) has played a pivotal role in understanding protein turn over. The main objective of this work was to develop a c...

journal_title：Cell biology and toxicology

authors： Keyomarsi K,Efuet ET,Bui TN

更新日期：2011-04-01 00:00:00

abstract：:The effect of noncytotoxic doses of argemone oil (AO) and butter yellow (BY), the common adulterants in edible oil, on free radical generation and signaling pathway for cell proliferation in primary cells of gall bladder (GB) was undertaken. AO and BY showed no cytotoxicity at 0.1 μl/ml and 0.1 μg/ml concentration, re...

journal_title：Cell biology and toxicology

authors： Mishra V,Ansari KM,Khanna R,Das M

更新日期：2012-06-01 00:00:00

abstract：:A useful approach for constructing dose-response relationships and for studying the underlying mechanisms by which a xenobiotic agent enhances airway reactivity is to measure the response of an isolated airway following ex vivo exposure to a pollutant. We have in this way determined the dose-response relationship betw...

journal_title：Cell biology and toxicology

authors： Roux E,Ouedraogo N,Hyvelin JM,Savineau JP,Marthan R

更新日期：2002-01-01 00:00:00

abstract：:Inhibition of endosomal acidification disturbs insulin signaling in both liver and adipose cells. In this study we used MIN6 beta cells to determine whether bafilomycin, a potent inhibitor of the proton-translocating vacuolar ATPase, disrupts insulin signaling in islet beta cells. Pretreatment of MIN6 cells with varyi...

journal_title：Cell biology and toxicology

authors： Hettiarachchi KD,Zimmet PZ,Myers MA

更新日期：2006-05-01 00:00:00

abstract：:The culture of rabbit tenocytes could be a useful model in the study of the physiopathology and pharmacotoxicology of tendons. This work was undertaken to examine the in vitro behavior of tenocytes form juvenile rabbit Achilles tendons. We report observations of the morphological and biological characteristics of prim...

journal_title：Cell biology and toxicology

authors： Bernard-Beaubois K,Hecquet C,Houcine O,Hayem G,Adolphe M

更新日期：1997-02-01 00:00:00

abstract：:Recepteur d'origine nantais (RON) has been implicated in cell proliferation, metastasis, and chemoresistance of various human malignancies. The short-form RON (sf-RON) encoded by RON transcripts was overexpressed in gastric cancer tissues, but its regulatory functions remain illustrated. Here, we found that sf-RON pro...

journal_title：Cell biology and toxicology

authors： Wang Z,Yang Y,Hu S,He J,Wu Z,Qi Z,Huang M,Liu R,Lin Y,Tan C,Xu M,Zhang Z

更新日期：2021-02-01 00:00:00

abstract：:In previous studies cadmium chloride (CdCl2) nonlethally inhibited Y-1 adrenal mouse adrenal tumour cell 20-dihydroxyprogesterone (20DHP) secretion, affecting unstimulated and stimulated steroidogenic pathway sites differently. We studied CdCl2 effects on unstimulated steroidogenesis using Y-1 cells incubated 0.5 h in...

journal_title：Cell biology and toxicology

authors： Mgbonyebi OP,Smothers CT,Mrotek JJ

更新日期：1994-02-01 00:00:00

abstract：:Mechanisms of cell death induced by toxins probably involve one or more processes such as inhibition of protein synthesis and impairment of plasma membrane integrity leading to an increase in membrane permeability. Since one of the possible actions of mastoparan, a cationic tetradecapeptide from wasp venom, is to pert...

journal_title：Cell biology and toxicology

authors： Eng SP,Lo CS

更新日期：1990-01-01 00:00:00

abstract：:In a number of adverse drug reactions leading to hepatotoxicity drug metabolism is thought to be involved by generation of reactive metabolites from nontoxic drugs. In this study, an in vitro assay was developed for measurement of the impact of metabolic activation of compound on the cytotoxicity toward a human hepati...

journal_title：Cell biology and toxicology

authors： Otto M,Hansen SH,Dalgaard L,Dubois J,Badolo L

更新日期：2008-01-01 00:00:00

abstract：:Male albino rats with diabetes induced by the administration of streptozotocin (STZ) (45 mg/kg, i.v.) were treated with oral administration of diphenyl diselenide (DPDS) pre-dissolved in soya bean oil. A significant reduction in blood glucose levels was observed in STZ-induced diabetic rats treated with DPDS compared ...

journal_title：Cell biology and toxicology

authors： Kade IJ,Borges VC,Savegnago L,Ibukun EO,Zeni G,Nogueira CW,Rocha JB

更新日期：2009-08-01 00:00:00

abstract：:The effects of aplysiatoxin and debromoaplysiatoxin on the clonal growth rate, cross-linked envelope formation and plasminogen activator secretion of normal human bronchial epithelial cells were studied. Neither compound was mitogenic over a wide range of concentrations (10(-13) to 10(-7)M). Both aplysiatoxin and debr...

journal_title：Cell biology and toxicology

authors： Willey JC,Moser CE Jr,Harris CC

更新日期：1984-10-01 00:00:00

abstract：:The response of fatty liver to stress conditions (t-butyl hydroperoxide [t-BH] or 36 h of fasting) was investigated by assessing intracellular glutathione (GSH) compartmentation and redox status, GSH peroxidase (GSH-Px) and reductase (GSSG-Rx) activities, lipid peroxidation (TBARs) and serum ALT levels in rats on a ch...

journal_title：Cell biology and toxicology

authors： Grattagliano I,Caraceni P,Portincasa P,Domenicali M,Palmieri VO,Trevisani F,Bernardi M,Palasciano G

更新日期：2003-11-01 00:00:00

abstract：:Many of the differentiated functions of hepatocytes are lost in culture, yet addition of certain medium supplements can aid in the retention of differentiated character. Therefore, the effect of time in monolayer culture on rat hepatocyte glutathione (GSH) synthesis and sensitivity to the GSH detoxicated xenobiotic et...

journal_title：Cell biology and toxicology

authors： Meredith MJ

更新日期：1986-12-01 00:00:00

abstract：:In order to clarify the protective mechanism of sodium molybdate against the acute toxicity of cadmium chloride in rat, the effect of in vivo sodium molybdate pretreatment on the cytotoxic action of cadmium in isolated hepatocytes was studied. The cytosolic pH of hepatocytes isolated from untreated rats immediately de...

journal_title：Cell biology and toxicology

authors： Koizumi T,Yokota T,Fukuchi M,Tatsumoto H,Yamane Y

更新日期：1991-10-01 00:00:00

abstract：:The heat-stable enterotoxin (Y-STa) produced by the pathogenic strains of Yersinia enterocolitica is a causative agent of secretory diarrhea. We have reported earlier that Y-STa-induced inositol trisphosphate-mediated cytosolic calcium rise occurs in rat intestinal epithelial cells. In the present communication, the i...

journal_title：Cell biology and toxicology

authors： Saha S,Chowdhury P,Mazumdar A,Pal A,Das P,Chakrabarti MK

更新日期：2009-06-01 00:00:00

abstract：:Sea urchin embryos and larvae represent suitable model systems on where to investigate the effects of heavy metals on development and cell viability. Here, we tested the toxic effects of low (10(-12 )M), medium (10(-9 )M), and high (10(-6 )M) cadmium chloride concentrations, mimicking unpolluted, moderately and highly...

journal_title：Cell biology and toxicology

authors： Filosto S,Roccheri MC,Bonaventura R,Matranga V

更新日期：2008-12-01 00:00:00

abstract：:The effects of the oxidizing agent t-butylhydroperoxide (t-BHP) were investigated on three human cell lines of different origin and growth features (A431 epithelial cells, ADF astrocytoma cells and U937 leukemic cells) using electron microscopy and electron paramagnetic resonance spectroscopy. The results indicate tha...

journal_title：Cell biology and toxicology

authors： Malorni W,Rainaldi G,Rivabene R,Santini MT

更新日期：1994-08-01 00:00:00

abstract：OBJECTIVES:LncRNAs (long noncoding RNAs) have been reported to critically regulate colorectal cancer (CRC). We prospectively investigated effects and mechanisms of lncRNA LINC00858 on regulation of CRC progression. METHODS:Expression of LINC00858 and its target were analyzed by quantitative real-time polymerase chain ...

journal_title：Cell biology and toxicology

authors： Zhan W,Liao X,Chen Z,Li L,Tian T,Yu L,Li R

更新日期：2020-08-01 00:00:00

abstract：:Skin intoxication by bis(beta-chloroethyl)sulfide (BCES; sulfur mustard) induces cutaneous lesions similar to thermal burns, characterized by slowness of skin healing. We have developed an in vitro model of skin equivalent to investigate mechanisms involved in this delay. Direct intoxication of dermal equivalent produ...

journal_title：Cell biology and toxicology

authors： Gentilhomme E,Reano A,Pradel D,Bergier J,Schmitt D,Neveux Y

更新日期：1998-02-01 00:00:00