Enhancement of aldehyde dehydrogenase activity in human and rat hepatocyte cultures by 3-methylcholanthrene.

abstract：:[Pt(O,O'-acac)(γ-acac)(DMS)] (PtAcacDMS) is a new platinum compound showing low reactivity with nucleobases and specific reactivity with sulfur ligands intracellularly. It induces apoptosis in breast cancer cells, but appears to be less neurotoxic to the developing cerebellum than cisplatin (cisPt). The aim of this st...

journal_title：Cell biology and toxicology

authors： Piccolini VM,Bottone MG,Bottiroli G,De Pascali SA,Fanizzi FP,Bernocchi G

更新日期：2013-10-01 00:00:00

abstract：:During the last decade, the unbound glutathione content of cultured adherent cells has become a very important biological marker for many pharmacological and toxicological in vitro studies with regard to the protective role of the tripeptide in its reduced form (GSH). However, the literature does not provide extensive...

journal_title：Cell biology and toxicology

authors： Thioudellet C,Oster T,Leroy P,Nicolas A,Wellman M

更新日期：1995-04-01 00:00:00

abstract：:Rats chronically exposed to acrylonitrile (ACN) have shown a dose-dependent increase in the incidence of astrocytomas in the brain. The mechanism(s) by which ACN induces cancer in rodents has not been established. ACN does not appear to be directly genotoxic in the brain and thus a nongenotoxic mode of action has been...

journal_title：Cell biology and toxicology

authors： Kamendulis LM,Jiang J,Zhang H,deFeijter-Rupp H,Trosko JE,Klaunig JE

更新日期：1999-06-01 00:00:00

abstract：:In order to clarify the protective mechanism of sodium molybdate against the acute toxicity of cadmium chloride in rat, the effect of in vivo sodium molybdate pretreatment on the cytotoxic action of cadmium in isolated hepatocytes was studied. The cytosolic pH of hepatocytes isolated from untreated rats immediately de...

journal_title：Cell biology and toxicology

authors： Koizumi T,Yokota T,Fukuchi M,Tatsumoto H,Yamane Y

更新日期：1991-10-01 00:00:00

abstract：:Mechanisms of cell death induced by toxins probably involve one or more processes such as inhibition of protein synthesis and impairment of plasma membrane integrity leading to an increase in membrane permeability. Since one of the possible actions of mastoparan, a cationic tetradecapeptide from wasp venom, is to pert...

journal_title：Cell biology and toxicology

authors： Eng SP,Lo CS

更新日期：1990-01-01 00:00:00

abstract：:Magnesium, an essential metal that is important in the normal functioning of DNA, has been shown to interact with some of the toxic heavy metals in respect to biochemical and molecular mechanisms and in altering the tumorigenic process. This study examined the influence of magnesium in combination with nickel and cadm...

journal_title：Cell biology and toxicology

authors： Littlefield NA,Hass BS,James SJ,Poirier LA

更新日期：1994-04-01 00:00:00

abstract：:In a number of adverse drug reactions leading to hepatotoxicity drug metabolism is thought to be involved by generation of reactive metabolites from nontoxic drugs. In this study, an in vitro assay was developed for measurement of the impact of metabolic activation of compound on the cytotoxicity toward a human hepati...

journal_title：Cell biology and toxicology

authors： Otto M,Hansen SH,Dalgaard L,Dubois J,Badolo L

更新日期：2008-01-01 00:00:00

abstract：:Cd2+ provokes inositol trisphosphate production and releases stored Ca2+, apparently by binding to a zinc site in the external domain of an orphan receptor. One microM Cd2+ evokes an immediate spike in cytosolic free Ca2+, which is similar to that evoked by bradykinin. Platelet-derived growth factor (PDGF) also increa...

journal_title：Cell biology and toxicology

authors： Lyu RM,Smith JB

更新日期：1993-04-01 00:00:00

abstract：:The mutagenic activity of the pyrolysis products 2-amino-3-methyl-imidazo[4,5-f]-quinoline 2-amino-3,4-dimethylimidazo[4,5-f]-quinoline in Salmonella typhimurium TA98 using rat intestinal and renal subcellular fractions as activation systems was approximately 1 and 5 revertants per nmol, respectively. This was 1,000 t...

journal_title：Cell biology and toxicology

authors： Holme JA,Alexander J,Dybing E

更新日期：1987-03-01 00:00:00

abstract：:Presently, a large effort is being made worldwide to increase the sustainability of industrial development, while preserving not only the quality of the environment but also that of animal and human life. In this work, sea urchin early developmental stages were used as a model to test the effects of the organophosphat...

journal_title：Cell biology and toxicology

authors： Aluigi MG,Angelini C,Corte G,Falugi C

更新日期：2008-12-01 00:00:00

abstract：:Inhibition of endosomal acidification disturbs insulin signaling in both liver and adipose cells. In this study we used MIN6 beta cells to determine whether bafilomycin, a potent inhibitor of the proton-translocating vacuolar ATPase, disrupts insulin signaling in islet beta cells. Pretreatment of MIN6 cells with varyi...

journal_title：Cell biology and toxicology

authors： Hettiarachchi KD,Zimmet PZ,Myers MA

更新日期：2006-05-01 00:00:00

abstract：:Generating large amounts of recombinant protein in transgenic animals is often challenging and has a number of drawbacks compared to cell culture systems. The baculovirus expression vector system (BEVS) uses virus-infected insect cells to produce recombinant proteins to high levels, and these are usually processed in ...

journal_title：Cell biology and toxicology

authors： Hitchman RB,Possee RD,Crombie AT,Chambers A,Ho K,Siaterli E,Lissina O,Sternard H,Novy R,Loomis K,Bird LE,Owens RJ,King LA

更新日期：2010-02-01 00:00:00

abstract：:Glioblastoma (GBM) is the most aggressive type of glioma. Temozolomide (TMZ) is currently the drug of choice used for post-operative chemotherapy of GBM. However, the presence of intrinsic and acquired resistance hinders the success of chemotherapy. To understand the TMZ resistant mechanisms in glioma, we investigated...

journal_title：Cell biology and toxicology

authors： Tomar VS,Patil V,Somasundaram K

更新日期：2020-06-01 00:00:00

abstract：:Quinones are widely distributed in the environment, both as natural products and as pollutants. This paper reports that one of the simplest quinones, 2-methyl-1,4-naphthoquinone (menadione), effectively inhibited apoptosis in the presence of UVA. Menadione suppressed the apoptosis induced by serum depletion and cell d...

journal_title：Cell biology and toxicology

authors： Ibuki Y,Toyooka T,Goto R

更新日期：2006-09-01 00:00:00

abstract：:The risk presented by mycotoxins is a toxicological problem. As the data given by physico-chemical analysis may be difficult to translate in terms of toxicity, however, especially when considering multiple contamination, we have developed a system for toxicological analysis of mycotoxins using cell cultures of differe...

journal_title：Cell biology and toxicology

authors： Robbana-Barnat S,Lafarge-Frayssinet C,Frayssinet C

更新日期：1989-06-01 00:00:00

abstract：:Sea urchin embryos and larvae represent suitable model systems on where to investigate the effects of heavy metals on development and cell viability. Here, we tested the toxic effects of low (10(-12 )M), medium (10(-9 )M), and high (10(-6 )M) cadmium chloride concentrations, mimicking unpolluted, moderately and highly...

journal_title：Cell biology and toxicology

authors： Filosto S,Roccheri MC,Bonaventura R,Matranga V

更新日期：2008-12-01 00:00:00

abstract：:We assessed the in vitro toxicity of various particles on three murine macrophage cell lines, (J774A.1, WR19M.1, RAW264.7). The cells were exposed to aqueous suspensions (0-100 microg/30 mm2 well) of urban particulate matter (SRM-1648, SRM-1649, EHC-93), fine particulate matter (PM2.5), titanium dioxide (SRM-154b), an...

journal_title：Cell biology and toxicology

authors： Chauhan V,Breznan D,Goegan P,Nadeau D,Karthikeyan S,Brook JR,Vincent R

更新日期：2004-07-01 00:00:00

abstract：:The heat-stable enterotoxin (Y-STa) produced by the pathogenic strains of Yersinia enterocolitica is a causative agent of secretory diarrhea. We have reported earlier that Y-STa-induced inositol trisphosphate-mediated cytosolic calcium rise occurs in rat intestinal epithelial cells. In the present communication, the i...

journal_title：Cell biology and toxicology

authors： Saha S,Chowdhury P,Mazumdar A,Pal A,Das P,Chakrabarti MK

更新日期：2009-06-01 00:00:00

abstract：:Recent studies have demonstrated that the insecticide DDT is a tumor promoting agent. Similar to many other tumor promoting agents, DDT has been shown to inhibit gap junctional intercellular communication (GJIC) between cells in culture, and it has been suggested that DDT-induced loss of communication between adjacent...

journal_title：Cell biology and toxicology

authors： Fransson R,Nicotera P,Wärngård L,Ahlborg UG

更新日期：1990-04-01 00:00:00

abstract：:The piperidine nitroxides Tempamine and Tempace have been studied for their effect on doxorubicin (DOX) and hydrogen peroxide (H(2)O(2)) cytotoxicity in immortalized B14 cells, a model for neoplastic phenotype. The significance for nitroxide performance of the substituent in position 4 of the piperidine ring was evalu...

journal_title：Cell biology and toxicology

authors： Czepas J,Koceva-Chyła A,Gwoździński K,Jóźwiak Z

更新日期：2008-01-01 00:00:00

abstract：:Although methylguanine-DNA-methyltransferase (MGMT) plays an important role in resistance to temozolomide (TMZ) in glioma, 40% of gliomas with MGMT inactivation are still resistant to TMZ. The underlying mechanism is not clear. Here, we report that forkhead box M1 (FoxM1) transcriptionally activates the expression of ...

journal_title：Cell biology and toxicology

authors： Peng WX,Han X,Zhang CL,Ge L,Du FY,Jin J,Gong AH

更新日期：2017-12-01 00:00:00

abstract：:Recepteur d'origine nantais (RON) has been implicated in cell proliferation, metastasis, and chemoresistance of various human malignancies. The short-form RON (sf-RON) encoded by RON transcripts was overexpressed in gastric cancer tissues, but its regulatory functions remain illustrated. Here, we found that sf-RON pro...

journal_title：Cell biology and toxicology

authors： Wang Z,Yang Y,Hu S,He J,Wu Z,Qi Z,Huang M,Liu R,Lin Y,Tan C,Xu M,Zhang Z

更新日期：2021-02-01 00:00:00

abstract：:The effect of noncytotoxic doses of argemone oil (AO) and butter yellow (BY), the common adulterants in edible oil, on free radical generation and signaling pathway for cell proliferation in primary cells of gall bladder (GB) was undertaken. AO and BY showed no cytotoxicity at 0.1 μl/ml and 0.1 μg/ml concentration, re...

journal_title：Cell biology and toxicology

authors： Mishra V,Ansari KM,Khanna R,Das M

更新日期：2012-06-01 00:00:00

abstract：:We investigated mitogen-activated protein kinase (MAPK) pathways as well as reactive oxygen species (ROS) in olaquindox-induced apoptosis. Exposure of HepG2 cells to olaquindox resulted in the phosphorylation of p38 MAPK and c-Jun N-terminal kinases (JNK). To confirm the role of p38 MAPK and JNK, HepG2 cells were pret...

journal_title：Cell biology and toxicology

authors： Zhao WX,Tang SS,Jin X,Zhang CM,Zhang T,Wang CC,Sun Y,Xiao XL

更新日期：2013-08-01 00:00:00

abstract：:Two human hepatoma cell lines, KYN-2 and Mz-Hep-1 were characterized in terms of glucuronidation capacity and inducibility of cytochrome P4501A1/1A2 and several UDP-glucuronosyltransferases (UGTs). Cytochrome P4501A1/1A2 activity was measured using 7-ethoxyresorufin and that of UGTs with 16 different substrates. The e...

journal_title：Cell biology and toxicology

authors： Abid A,Sabolovic N,Magdalou J

更新日期：1996-04-01 00:00:00

abstract：:Okadaic acid (OA), produced by dinoflagellates during harmful algal blooms (HAB), belongs to the Diarrheic Shellfish Poisoning toxins that cause gastrointestinal symptoms in humans after consumption. In the present work, Ruditapes decussatus haemocytes were selected to evaluate the effect of OA on cell viability, enzy...

journal_title：Cell biology and toxicology

authors： Prado-Alvarez M,Flórez-Barrós F,Méndez J,Fernandez-Tajes J

更新日期：2013-06-01 00:00:00

abstract：:An in vitro human nasal model was developed as a tool to study the local tolerability of nasal powder forms using excised nasal mucosa in a diffusion chamber. The suitability of this model was tested using Sandostatin (SMS) an octapeptide analog of somatostatin, as a reference drug enhanced by Avicel (microcrystalline...

journal_title：Cell biology and toxicology

authors： de Fraissinette A,Kolopp M,Schiller I,Fricker G,Gammert C,Pospischil A,Vonderscher J,Richter F

更新日期：1995-10-01 00:00:00

abstract：:To select an insert suitable for human umbilical vein endothelial cell (HUVEC) culture, we compared several available inserts of 0.2 to 0.45 micron porosity: Cellagen (ICN), Transwell-COL (Costar), Millicell-HA and CM (Millipore), Anopore (Nunc), Cyclopore (Falcon) in comparison with a control surface (Thermanox). The...

journal_title：Cell biology and toxicology

authors： Villars F,Conrad V,Rouais F,Lefebvre F,Amédée J,Bordenave L

更新日期：1996-12-01 00:00:00

abstract：:DNA methylation is catalyzed by a family of DNA methyltransferases (DNMTs) including the maintenance enzyme DNMT 1 and de novo methyltransferases DNMT 3a and DNMT 3b. Elevated levels of DNMTs have been found in cancer cells and in several types of human tumors. A polymorphism found in DNMT3b has been associated with i...

journal_title：Cell biology and toxicology

authors： Xiao Y,Word B,Starlard-Davenport A,Haefele A,Lyn-Cook BD,Hammons G

更新日期：2008-06-01 00:00:00

abstract：:The culture of rabbit tenocytes could be a useful model in the study of the physiopathology and pharmacotoxicology of tendons. This work was undertaken to examine the in vitro behavior of tenocytes form juvenile rabbit Achilles tendons. We report observations of the morphological and biological characteristics of prim...

journal_title：Cell biology and toxicology

authors： Bernard-Beaubois K,Hecquet C,Houcine O,Hayem G,Adolphe M

更新日期：1997-02-01 00:00:00