abstract：:Recepteur d'origine nantais (RON) has been implicated in cell proliferation, metastasis, and chemoresistance of various human malignancies. The short-form RON (sf-RON) encoded by RON transcripts was overexpressed in gastric cancer tissues, but its regulatory functions remain illustrated. Here, we found that sf-RON pro...

journal_title：Cell biology and toxicology

authors： Wang Z,Yang Y,Hu S,He J,Wu Z,Qi Z,Huang M,Liu R,Lin Y,Tan C,Xu M,Zhang Z

更新日期：2021-02-01 00:00:00

abstract：:Autophagy is a conserved lysosomal degradation process, and abnormal autophagy has been associated with various pathological processes, e.g., neurodegeneration, cancer, and pathogen infection. Small chemical modulators of autophagy show the potential to treat autophagy-associated diseases. Diterpenoids, nature product...

journal_title：Cell biology and toxicology

authors： Huang L,Fu Q,Dai JM,Yan BC,Wang D,Puno PT,Yue J

更新日期：2021-01-23 00:00:00

abstract：:Microcystin-leucine-arginine (MC-LR) was produced by toxic cyanobacteria, which has been shown to have potent hepatotoxicity. Our previous study has proved that MC-LR were able to promote intrahepatic biliary epithelial cell excessive proliferation. However, the underlying mechanism is not yet entirely clarified. Here...

journal_title：Cell biology and toxicology

authors： Yan M,Gu S,Pan C,Chen Y,Han X

更新日期：2021-01-21 00:00:00

abstract：:In the US alone, around 60,000 lives/year are lost to colon cancer. In order to study the mechanisms of colon carcinogenesis, in vitro model systems are required in addition to in vivo models. Towards this end, we have used the HT-29 colon cancer cells, cultured in Dulbecco's Modified Eagle Medium (DMEM), which were e...

journal_title：Cell biology and toxicology

authors： Myers JN,Harris KL,Rekhadevi PV,Pratap S,Ramesh A

更新日期：2021-01-07 00:00:00

abstract：:Cholestatic liver injury, a group of diseases characterized with dysregulated bile acid (BA) homeostasis, was partly resulted from BA circulation disorders, which is commonly associated with the damage of hepatocyte barrier function. However, the underlying hepatocyte barrier-protective molecular mechanisms of cholest...

journal_title：Cell biology and toxicology

authors： Yang T,Wang X,Zhou Y,Yu Q,Heng C,Yang H,Yuan Z,Miao Y,Chai Y,Wu Z,Sun L,Huang X,Liu B,Jiang Z,Zhang L

更新日期：2021-01-05 00:00:00

abstract：:The mutation rates of tumor suppressor protein p53 gene (TP53) are high in lung adenocarcinoma and promote the development of acquired drug resistance. The present study evaluated the p53-dependent role in lung cancer cell sensitivity to PI3K-specific inhibitors, PI3K-associated inhibitors, PI3K-non-related inhibitors...

journal_title：Cell biology and toxicology

authors： Hou J,Cao X,Cheng Y,Wang X

更新日期：2020-10-01 00:00:00

abstract：:Recent findings suggest a functional interaction of the drug resistance enzyme glutathione S-transferase P (GSTP) with the transcription factor Nrf2, a master regulator of the adaptive stress response to cellular electrophiles. The effect of this interaction on the metabolism and redox of cellular thiols was investiga...

journal_title：Cell biology and toxicology

authors： Bartolini D,Giustarini D,Pietrella D,Rossi R,Galli F

更新日期：2020-08-01 00:00:00

abstract：OBJECTIVES:LncRNAs (long noncoding RNAs) have been reported to critically regulate colorectal cancer (CRC). We prospectively investigated effects and mechanisms of lncRNA LINC00858 on regulation of CRC progression. METHODS:Expression of LINC00858 and its target were analyzed by quantitative real-time polymerase chain ...

journal_title：Cell biology and toxicology

authors： Zhan W,Liao X,Chen Z,Li L,Tian T,Yu L,Li R

更新日期：2020-08-01 00:00:00

abstract：:Ziram, a zinc dithiocarbamate is widely used worldwide as a fungicide in agriculture. In order to investigate ziram-induced changes in macrophage functions and polarization, human monocytes-derived macrophages in culture were treated with ziram at 0.01-10 μmol.L-1 for 4-24 h. To characterize zinc involvement in these ...

journal_title：Cell biology and toxicology

authors： Parny M,Bernad J,Prat M,Salon M,Aubouy A,Bonnafé E,Coste A,Pipy B,Treilhou M

更新日期：2020-07-25 00:00:00

abstract：:Glioblastoma (GBM) is the most aggressive type of glioma. Temozolomide (TMZ) is currently the drug of choice used for post-operative chemotherapy of GBM. However, the presence of intrinsic and acquired resistance hinders the success of chemotherapy. To understand the TMZ resistant mechanisms in glioma, we investigated...

journal_title：Cell biology and toxicology

authors： Tomar VS,Patil V,Somasundaram K

更新日期：2020-06-01 00:00:00

abstract：:The article Is the clinical lipidomics a potential goldmine?, written by Linlin Zhang, Xianlin Han and Xiangdong Wang, was originally published electronically on the publisher's internet portal (currently SpringerLink) on 21 July 2018 with open access. With the author(s)' decision to step. ...

journal_title：Cell biology and toxicology

authors： Zhang L,Han X,Wang X

更新日期：2020-06-01 00:00:00

abstract：:Owing to the excellent antibacterial and antiviral activity, silver nanoparticles have a widespread use in the food and pharmaceutical industries. With the increase in the production and use of the related products, the potential hazard of silver nanoparticles has aroused public attention. The main purpose of this stu...

journal_title：Cell biology and toxicology

authors： Li L,Bi Z,Hu Y,Sun L,Song Y,Chen S,Mo F,Yang J,Wei Y,Wei X

更新日期：2020-05-04 00:00:00

abstract：:The goal of cancer eradication has been overshadowed despite the continuous improvement in research and generation of novel cancer therapeutic drugs. One of the undeniable existing problems is drug resistance due to which the paradigm of killing all cancer cells is ineffective. Tumor microenvironment plays a crucial r...

journal_title：Cell biology and toxicology

authors： Kadel D,Zhang Y,Sun HR,Zhao Y,Dong QZ,Qin LX

更新日期：2019-10-01 00:00:00

abstract：BACKGROUND AND AIMS:Endoplasmic reticulum (ER) stress is a growing concern for drug-induced toxicity which causes several side effects. Ritonavir, a potent HIV protease inhibitor, induces both ER and mitochondrial stress; however, the missing link between ER stress and mitochondrial damage has been unknown. In the pres...

journal_title：Cell biology and toxicology

authors： Ganta KK,Chaubey B

更新日期：2019-06-01 00:00:00

abstract：:The polyether toxin, okadaic acid, causes diarrhetic shellfish poisoning in humans. Despite extensive research into its cellular targets using rodent models, we know little about its putative effect(s) on innate immunity. We inoculated larvae of the greater wax moth, Galleria mellonella, with physiologically relevant ...

journal_title：Cell biology and toxicology

authors： Coates CJ,Lim J,Harman K,Rowley AF,Griffiths DJ,Emery H,Layton W

更新日期：2019-06-01 00:00:00

abstract：:The mesothelial cells (MCs) play an important role in the morpho-functional alterations of the peritoneal membrane (PM) undergoing peritoneal dialysis (PD). MCs, through the epithelial-mesenchymal transition process (EMT), progressively acquire a myofibroblast-like phenotype, promoting peritoneal fibrosis (PF) and fai...

journal_title：Cell biology and toxicology

authors： Lupinacci S,Perri A,Toteda G,Vizza D,Puoci F,Parisi OI,Giordano F,Lofaro D,La Russa A,Bonofiglio M,Bonofiglio R

更新日期：2019-04-01 00:00:00

abstract：:Clinical tests of gene sequence, structure, and function are to predict, diagnose, monitor, and prognose human disease-specific phenomes, characters severities, durations, stages, and responses to therapy. The concept and content of gene tests for clinical application mainly include chromosome/chromatins, DNA, and RNA...

journal_title：Cell biology and toxicology

authors： Wu D,Cheng Y,Wang X,CSGT group.

更新日期：2019-04-01 00:00:00

abstract：:Manganese exposure is among the many environmental risk factors linked to the progression of neurodegenerative diseases, such as manganese-induced parkinsonism. In animal models, chronic exposure to manganese causes loss of cell viability, neurodegeneration, and functional deficits. Polyamines, such as spermine, have ...

journal_title：Cell biology and toxicology

authors： Vijayan B,Raj V,Nandakumar S,Kishore A,Thekkuveettil A

更新日期：2019-04-01 00:00:00

abstract：:Lung cancer is one of the most common malignancies worldwide. Actinidia chinensis Planch root extract (acRoots) was found to have the capacity of the anti-tumor, although the molecular mechanisms remain unclear. The present study aims to investigate the molecular mechanisms by which lung cancer cells sense to inhibito...

journal_title：Cell biology and toxicology

authors： Lv J,Wang L,Shen H,Wang X

更新日期：2018-06-01 00:00:00

abstract：:Deoxynivalenol (DON), nivalenol (NIV), T-2 toxin (T2), fumonisin B1 (FB1), zearalenone (ZEA), and moniliformin (MON) mycotoxins are common food and feed contaminants produced by Fusarium spp. However, while they are usually found to co-occur in a large range of commodities, only few data are available on mycotoxin co-...

journal_title：Cell biology and toxicology

authors： Smith MC,Madec S,Troadec S,Coton E,Hymery N

更新日期：2018-06-01 00:00:00

abstract：:Cerebral infarction causes severe morbidity and mortality. Most patients with cerebral infarction should take antiplatelet drugs daily, so the effects of those drugs on the regeneration of the brain need to be investigated. Aspirin and clopidogrel are the most widely used antiplatelet drugs for the prevention of ische...

journal_title：Cell biology and toxicology

authors： Hwang M,Park HH,Choi H,Lee KY,Lee YJ,Koh SH

更新日期：2018-06-01 00:00:00

abstract：:Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) as a serious event has high mortality and medical costs. Systemic inflammation and immune response are the major factors influencing the outcome and quality of patient with AECOPD. On basis of identification and validation of AECOPD-specific inflamma...

journal_title：Cell biology and toxicology

authors： Shi L,Zhu B,Xu M,Wang X

更新日期：2018-04-01 00:00:00

abstract：:Although methylguanine-DNA-methyltransferase (MGMT) plays an important role in resistance to temozolomide (TMZ) in glioma, 40% of gliomas with MGMT inactivation are still resistant to TMZ. The underlying mechanism is not clear. Here, we report that forkhead box M1 (FoxM1) transcriptionally activates the expression of ...

journal_title：Cell biology and toxicology

authors： Peng WX,Han X,Zhang CL,Ge L,Du FY,Jin J,Gong AH

更新日期：2017-12-01 00:00:00

abstract：:Cellular accumulation of mono(2-ethylhexyl)phthalate (MEHP) has been recently demonstrated to disturb fat cell energy metabolism; however, the underlying mechanism remained unclear. The study aimed to determine how MEHP influenced fat cell transcriptome and how the changes might contribute to bioenergetics. Because of...

journal_title：Cell biology and toxicology

authors： Chiang HC,Wang CH,Yeh SC,Lin YH,Kuo YT,Liao CW,Tsai FY,Lin WY,Chuang WH,Tsou TC

更新日期：2017-12-01 00:00:00

abstract：:Aging, injuries, and diseases can be considered as the result of malfunctioning or damaged cells. Regenerative medicine aims to restore tissue homeostasis by repairing or replacing cells, tissues, or damaged organs, by linking and combining different disciplines including engineering, technology, biology, and medicine...

journal_title：Cell biology and toxicology

authors： Mora C,Serzanti M,Consiglio A,Memo M,Dell'Era P

更新日期：2017-08-01 00:00:00

abstract：:Exposure to compounds with cancer-potentiating effects can contribute to the progression of cancer. Herein we have discovered for the first time that benzophenone-3 (BP-3), a chemical used as sunscreen in various cosmetic products, enhances the ability of lung cancer cells to undergo metastasis. The exposure of the lu...

journal_title：Cell biology and toxicology

authors： Phiboonchaiyanan PP,Busaranon K,Ninsontia C,Chanvorachote P

更新日期：2017-06-01 00:00:00

abstract：:Ten years have passed since the first publication announcing the generation of induced pluripotent stem cells (iPSCs). Issues related to ethics, immune rejection, and cell availability seemed to be solved following this breakthrough. The development of iPSC technology allows advances in in vitro cell differentiation f...

journal_title：Cell biology and toxicology

authors： Paes BCMF,Moço PD,Pereira CG,Porto GS,de Sousa Russo EM,Reis LCJ,Covas DT,Picanço-Castro V

更新日期：2017-06-01 00:00:00

abstract：:Galectin 3 (Gal-3) is upregulated in gastric epithelial cells as a host response to Helicobacter pylori infection. However, the significance of Gal-3 expression in H. pylori-infected cells is not well established. We analyzed Gal-3 intracellular expression, localization, and its effects in H. pylori-infected gastric e...

journal_title：Cell biology and toxicology

authors： Subhash VV,Ho B

更新日期：2016-02-01 00:00:00

abstract：:Drug-induced liver injury (DILI) is a leading cause of discontinuation of new drug approval or withdrawal of marketed medicine based on safety due to organ vulnerability. The aim of this research is to investigate the potential abilities of four different in vitro cell models (L-02, HepG2, HepaRG, and hiHeps cell line...

journal_title：Cell biology and toxicology

authors： Wu Y,Geng XC,Wang JF,Miao YF,Lu YL,Li B

更新日期：2016-02-01 00:00:00

abstract：:Adverse effect of nanoparticles may include impairment of phagocyte function. To identify the effect of nanoparticle size on uptake, cytotoxicity, chemotaxis, cytokine secretion, phagocytosis, oxidative burst, nitric oxide production and myeloperoxidase release, leukocytes isolated from human peripheral blood, monocyt...

journal_title：Cell biology and toxicology

authors： Prietl B,Meindl C,Roblegg E,Pieber TR,Lanzer G,Fröhlich E

更新日期：2014-02-01 00:00:00

abstract：:[Pt(O,O'-acac)(γ-acac)(DMS)] (PtAcacDMS) is a new platinum compound showing low reactivity with nucleobases and specific reactivity with sulfur ligands intracellularly. It induces apoptosis in breast cancer cells, but appears to be less neurotoxic to the developing cerebellum than cisplatin (cisPt). The aim of this st...

journal_title：Cell biology and toxicology

authors： Piccolini VM,Bottone MG,Bottiroli G,De Pascali SA,Fanizzi FP,Bernocchi G

更新日期：2013-10-01 00:00:00

abstract：:We investigated mitogen-activated protein kinase (MAPK) pathways as well as reactive oxygen species (ROS) in olaquindox-induced apoptosis. Exposure of HepG2 cells to olaquindox resulted in the phosphorylation of p38 MAPK and c-Jun N-terminal kinases (JNK). To confirm the role of p38 MAPK and JNK, HepG2 cells were pret...

journal_title：Cell biology and toxicology

authors： Zhao WX,Tang SS,Jin X,Zhang CM,Zhang T,Wang CC,Sun Y,Xiao XL

更新日期：2013-08-01 00:00:00

abstract：:Metolachlor, a commonly used herbicide in the Midwestern USA, functions by inhibiting chlorophyll and protein synthesis in target plants. Herbicide exposure has led to detrimental effects in several organisms, affecting their growth and behavior; however, its mechanism of action in nontarget organisms is not yet clear...

journal_title：Cell biology and toxicology

authors： Lowry DM,Greiner D,Fretheim M,Ubben M,Dhanwada KR

更新日期：2013-08-01 00:00:00

abstract：:It has been well documented in in vitro studies that ambient airborne particulate matter (PM) with an aerodynamic diameter less than 2.5 μm (PM(2.5)) is capable of inducing oxidative stress, which plays a key role in PM(2.5)-mediated cytotoxicity. Although nuclear factor erythroid-2-related factor 2 (Nrf2) has been sh...

journal_title：Cell biology and toxicology

authors： Deng X,Rui W,Zhang F,Ding W

更新日期：2013-06-01 00:00:00

abstract：:Okadaic acid (OA), produced by dinoflagellates during harmful algal blooms (HAB), belongs to the Diarrheic Shellfish Poisoning toxins that cause gastrointestinal symptoms in humans after consumption. In the present work, Ruditapes decussatus haemocytes were selected to evaluate the effect of OA on cell viability, enzy...

journal_title：Cell biology and toxicology

authors： Prado-Alvarez M,Flórez-Barrós F,Méndez J,Fernandez-Tajes J

更新日期：2013-06-01 00:00:00

abstract：:Folic acid (FA) is a vitamin essential for normal cellular functions, growth, and development. Because humans cannot synthesize this micronutrient, it must be obtained from dietary sources through intestinal absorption. The intestinal tract is a major target for oxidative stress. Our aim was to investigate the effect ...

journal_title：Cell biology and toxicology

authors： Couto MR,Gonçalves P,Catarino T,Araújo JR,Correia-Branco A,Martel F

更新日期：2012-12-01 00:00:00

abstract：:The effect of noncytotoxic doses of argemone oil (AO) and butter yellow (BY), the common adulterants in edible oil, on free radical generation and signaling pathway for cell proliferation in primary cells of gall bladder (GB) was undertaken. AO and BY showed no cytotoxicity at 0.1 μl/ml and 0.1 μg/ml concentration, re...

journal_title：Cell biology and toxicology

authors： Mishra V,Ansari KM,Khanna R,Das M

更新日期：2012-06-01 00:00:00

abstract：:Sensitivity of baker's yeast to disulfiram (DSF) and hypersensitivity of a mutant devoid of Cu, Zn-superoxide dismutase to this compound is reported, demonstrating that yeast may be a simple convenient eukaryotic model to study the mechanism of DSF toxicity. DSF was found to induce oxidative stress in yeast cells demo...

journal_title：Cell biology and toxicology

authors： Kwolek-Mirek M,Zadrag-Tecza R,Bartosz G

更新日期：2012-02-01 00:00:00

abstract：:We explored if epigenetic mechanisms could be involved in the down-regulated expression of catalase gene (CAT) in the doxorubicin-resistant acute myelogenous leukemia (AML)-2/DX100 cells. Down-regulated CAT expression in AML-2/DX100 cells was completely recovered after treatment of hydrogen peroxide (H(2)O(2)) and his...

journal_title：Cell biology and toxicology

authors： Lee TB,Moon YS,Choi CH

更新日期：2012-02-01 00:00:00

abstract：:Bisnaphthalimido compounds bis-intercalate to DNA via the major groove and are potentially potent cancer therapeutics. Previously, we incorporated natural polyamines as linkers connecting the two naphthalimido ring moieties to create a series of soluble bisnaphthalimidopropyl polyamines (BNIPPs). Here, extending earli...

journal_title：Cell biology and toxicology

authors： Bestwick CS,Ralton LD,Milne L,Kong Thoo Lin P,Duthie SJ

更新日期：2011-12-01 00:00:00