FoxM1-mediated RFC5 expression promotes temozolomide resistance.

abstract：:The nephrotoxic fungal toxins ochratoxin A (OA), ochratoxin B (OB) and citrinin (CIT) are natural contaminants of foods and feeds. While cytotoxicity assays have proven useful for establishing relative toxicity and structure function relationships within groups of fungal toxins, a drawback of in vitro bioassays is the...

journal_title：Cell biology and toxicology

authors： Bondy GS,Armstrong CL

更新日期：1998-10-01 00:00:00

abstract：:Cerebral infarction causes severe morbidity and mortality. Most patients with cerebral infarction should take antiplatelet drugs daily, so the effects of those drugs on the regeneration of the brain need to be investigated. Aspirin and clopidogrel are the most widely used antiplatelet drugs for the prevention of ische...

journal_title：Cell biology and toxicology

authors： Hwang M,Park HH,Choi H,Lee KY,Lee YJ,Koh SH

更新日期：2018-06-01 00:00:00

abstract：:Bisnaphthalimido compounds bis-intercalate to DNA via the major groove and are potentially potent cancer therapeutics. Previously, we incorporated natural polyamines as linkers connecting the two naphthalimido ring moieties to create a series of soluble bisnaphthalimidopropyl polyamines (BNIPPs). Here, extending earli...

journal_title：Cell biology and toxicology

authors： Bestwick CS,Ralton LD,Milne L,Kong Thoo Lin P,Duthie SJ

更新日期：2011-12-01 00:00:00

abstract：:We explored if epigenetic mechanisms could be involved in the down-regulated expression of catalase gene (CAT) in the doxorubicin-resistant acute myelogenous leukemia (AML)-2/DX100 cells. Down-regulated CAT expression in AML-2/DX100 cells was completely recovered after treatment of hydrogen peroxide (H(2)O(2)) and his...

journal_title：Cell biology and toxicology

authors： Lee TB,Moon YS,Choi CH

更新日期：2012-02-01 00:00:00

abstract：:Recepteur d'origine nantais (RON) has been implicated in cell proliferation, metastasis, and chemoresistance of various human malignancies. The short-form RON (sf-RON) encoded by RON transcripts was overexpressed in gastric cancer tissues, but its regulatory functions remain illustrated. Here, we found that sf-RON pro...

journal_title：Cell biology and toxicology

authors： Wang Z,Yang Y,Hu S,He J,Wu Z,Qi Z,Huang M,Liu R,Lin Y,Tan C,Xu M,Zhang Z

更新日期：2021-02-01 00:00:00

abstract：:Transforming growth factor-beta1 (TGF-beta1) can activate mitogen-activated protein kinases (MAPKs) in many types of cells. The mechanism of this activation is not well elucidated. Here, we explore the role of TGF-beta/Smads signaling compounds in TGF-beta1-mediated activation of extracellular signal-regulated kinase ...

journal_title：Cell biology and toxicology

authors： Huo YY,Hu YC,He XR,Wang Y,Song BQ,Zhou PK,Zhu MX,Li G,Wu DC

更新日期：2007-03-01 00:00:00

abstract：:To select an insert suitable for human umbilical vein endothelial cell (HUVEC) culture, we compared several available inserts of 0.2 to 0.45 micron porosity: Cellagen (ICN), Transwell-COL (Costar), Millicell-HA and CM (Millipore), Anopore (Nunc), Cyclopore (Falcon) in comparison with a control surface (Thermanox). The...

journal_title：Cell biology and toxicology

authors： Villars F,Conrad V,Rouais F,Lefebvre F,Amédée J,Bordenave L

更新日期：1996-12-01 00:00:00

abstract：:Galectin 3 (Gal-3) is upregulated in gastric epithelial cells as a host response to Helicobacter pylori infection. However, the significance of Gal-3 expression in H. pylori-infected cells is not well established. We analyzed Gal-3 intracellular expression, localization, and its effects in H. pylori-infected gastric e...

journal_title：Cell biology and toxicology

authors： Subhash VV,Ho B

更新日期：2016-02-01 00:00:00

abstract：:2,2'-Dichlorodiethyl sulfide (sulfur mustard, HD, 1,1'-thiobis [2-chloroethane]) is a potent vesicant which can cause severe lesions to skin, lung, and eyes. Due to the high number of debilitating exposures during the Iran-Iraq war to the alkylating agent, HD, there is an increased interest in its mechanism of action ...

journal_title：Cell biology and toxicology

authors： Meier HL

更新日期：1996-06-01 00:00:00

abstract：:In order to clarify the protective mechanism of sodium molybdate against the acute toxicity of cadmium chloride in rat, the effect of in vivo sodium molybdate pretreatment on the cytotoxic action of cadmium in isolated hepatocytes was studied. The cytosolic pH of hepatocytes isolated from untreated rats immediately de...

journal_title：Cell biology and toxicology

authors： Koizumi T,Yokota T,Fukuchi M,Tatsumoto H,Yamane Y

更新日期：1991-10-01 00:00:00

abstract：:Previous studies showed that the pesticide lindane (gamma-hexachlorocyclohexane) inhibits gap junction intercellular communication in rat myometrial cells. The present study tested the hypothesis that lindane and the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) inhibit gap junction communication in rat myo...

journal_title：Cell biology and toxicology

authors： Loch-Caruso R,Galvez MM,Brant K,Chung D

更新日期：2004-05-01 00:00:00

abstract：:Cd2+ provokes inositol trisphosphate production and releases stored Ca2+, apparently by binding to a zinc site in the external domain of an orphan receptor. One microM Cd2+ evokes an immediate spike in cytosolic free Ca2+, which is similar to that evoked by bradykinin. Platelet-derived growth factor (PDGF) also increa...

journal_title：Cell biology and toxicology

authors： Lyu RM,Smith JB

更新日期：1993-04-01 00:00:00

abstract：:We assessed the in vitro toxicity of various particles on three murine macrophage cell lines, (J774A.1, WR19M.1, RAW264.7). The cells were exposed to aqueous suspensions (0-100 microg/30 mm2 well) of urban particulate matter (SRM-1648, SRM-1649, EHC-93), fine particulate matter (PM2.5), titanium dioxide (SRM-154b), an...

journal_title：Cell biology and toxicology

authors： Chauhan V,Breznan D,Goegan P,Nadeau D,Karthikeyan S,Brook JR,Vincent R

更新日期：2004-07-01 00:00:00

abstract：:The purpose of the study was to determine whether along and in combination melatonin (MLT) and pentoxifylline (PTX) exerted beneficial effects on histopathological changes and changes in oxidant and antioxidant systems in liver caused by CCl4-induced liver toxicity in mice. Mice were randomly divided into six groups: ...

journal_title：Cell biology and toxicology

authors： Noyan T,Kömüroğlu U,Bayram I,Sekeroğlu MR

更新日期：2006-11-01 00:00:00

abstract：:Skin intoxication by bis(beta-chloroethyl)sulfide (BCES; sulfur mustard) induces cutaneous lesions similar to thermal burns, characterized by slowness of skin healing. We have developed an in vitro model of skin equivalent to investigate mechanisms involved in this delay. Direct intoxication of dermal equivalent produ...

journal_title：Cell biology and toxicology

authors： Gentilhomme E,Reano A,Pradel D,Bergier J,Schmitt D,Neveux Y

更新日期：1998-02-01 00:00:00

abstract：:Deoxynivalenol (DON), nivalenol (NIV), T-2 toxin (T2), fumonisin B1 (FB1), zearalenone (ZEA), and moniliformin (MON) mycotoxins are common food and feed contaminants produced by Fusarium spp. However, while they are usually found to co-occur in a large range of commodities, only few data are available on mycotoxin co-...

journal_title：Cell biology and toxicology

authors： Smith MC,Madec S,Troadec S,Coton E,Hymery N

更新日期：2018-06-01 00:00:00

abstract：:Recent studies have demonstrated that the insecticide DDT is a tumor promoting agent. Similar to many other tumor promoting agents, DDT has been shown to inhibit gap junctional intercellular communication (GJIC) between cells in culture, and it has been suggested that DDT-induced loss of communication between adjacent...

journal_title：Cell biology and toxicology

authors： Fransson R,Nicotera P,Wärngård L,Ahlborg UG

更新日期：1990-04-01 00:00:00

abstract：:Because of a possible role of astrocytes in trialkyltin-induced neurotoxicity in vivo various studies have been performed using cultures of astrocytes or glioma cells in vitro. With respect to cytotoxic potencies of trialkyltins these studies gave rather divergent results. Therefore the aim of the present study was to...

journal_title：Cell biology and toxicology

authors： Seibert H,Mörchel S,Gülden M

更新日期：2004-09-01 00:00:00

abstract：:The piperidine nitroxides Tempamine and Tempace have been studied for their effect on doxorubicin (DOX) and hydrogen peroxide (H(2)O(2)) cytotoxicity in immortalized B14 cells, a model for neoplastic phenotype. The significance for nitroxide performance of the substituent in position 4 of the piperidine ring was evalu...

journal_title：Cell biology and toxicology

authors： Czepas J,Koceva-Chyła A,Gwoździński K,Jóźwiak Z

更新日期：2008-01-01 00:00:00

abstract：:Okadaic acid (OA), produced by dinoflagellates during harmful algal blooms (HAB), belongs to the Diarrheic Shellfish Poisoning toxins that cause gastrointestinal symptoms in humans after consumption. In the present work, Ruditapes decussatus haemocytes were selected to evaluate the effect of OA on cell viability, enzy...

journal_title：Cell biology and toxicology

authors： Prado-Alvarez M,Flórez-Barrós F,Méndez J,Fernandez-Tajes J

更新日期：2013-06-01 00:00:00

abstract：:The cytogenetic and hepatotoxic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on mouse liver cells were investigated. Male C57BL/6J strain mice, which have TCDD receptors, were given single intraperitoneal injections of 25, 37.5, 75 and 150 micrograms of TCDD/kg body weight or corn oil carrier alone. Two-third...

journal_title：Cell biology and toxicology

authors： Brooks AL,Jordan SW,Bose KK,Smith J,Allison DC

更新日期：1988-03-01 00:00:00

abstract：:In the US alone, around 60,000 lives/year are lost to colon cancer. In order to study the mechanisms of colon carcinogenesis, in vitro model systems are required in addition to in vivo models. Towards this end, we have used the HT-29 colon cancer cells, cultured in Dulbecco's Modified Eagle Medium (DMEM), which were e...

journal_title：Cell biology and toxicology

authors： Myers JN,Harris KL,Rekhadevi PV,Pratap S,Ramesh A

更新日期：2021-01-07 00:00:00

abstract：:The response of fatty liver to stress conditions (t-butyl hydroperoxide [t-BH] or 36 h of fasting) was investigated by assessing intracellular glutathione (GSH) compartmentation and redox status, GSH peroxidase (GSH-Px) and reductase (GSSG-Rx) activities, lipid peroxidation (TBARs) and serum ALT levels in rats on a ch...

journal_title：Cell biology and toxicology

authors： Grattagliano I,Caraceni P,Portincasa P,Domenicali M,Palmieri VO,Trevisani F,Bernardi M,Palasciano G

更新日期：2003-11-01 00:00:00

abstract：:Knowledge of the acute toxic effects of chemicals is important for the protection of exposed humans. Since sufficient information in humans is often lacking, experiments on laboratory animals must be performed. The LD50 test, which requires large numbers of animals, has become the preferred procedure. It is now widely...

journal_title：Cell biology and toxicology

authors： Zbinden G

更新日期：1986-09-01 00:00:00

abstract：:Aldehyde dehydrogenase was measured in primary cultures of hepatocytes obtained with a two-step collagenase perfusion either from human hepatic tissue or from livers of Fisher rats. Basal enzyme activity declines gradually as a function of time in culture, but remains at all times higher when measured with propionalde...

journal_title：Cell biology and toxicology

authors： Marselos M,Strom SC,Michalopoulos G

更新日期：1986-06-01 00:00:00

abstract：:Bolesatine, a glycoprotein from Boletus satanas Lenz, has previously been shown to be mitogenic in rat and human lymphocytes at very low concentrations, whereas higher concentrations inhibited protein synthesis in vitro and in several in vivo systems. The low concentrations (1-10 ng/ml) of bolesatine were shown to act...

journal_title：Cell biology and toxicology

authors： Ennamany R,Marzetto S,Saboureau D,Creppy EE

更新日期：1995-12-01 00:00:00

abstract：:Generating large amounts of recombinant protein in transgenic animals is often challenging and has a number of drawbacks compared to cell culture systems. The baculovirus expression vector system (BEVS) uses virus-infected insect cells to produce recombinant proteins to high levels, and these are usually processed in ...

journal_title：Cell biology and toxicology

authors： Hitchman RB,Possee RD,Crombie AT,Chambers A,Ho K,Siaterli E,Lissina O,Sternard H,Novy R,Loomis K,Bird LE,Owens RJ,King LA

更新日期：2010-02-01 00:00:00

abstract：:In vitro directional migration of 10T1/2 fibroblasts is partially inhibited by TPA but not by its non-promoting analogues. Other tumor promoters, e.g., phenobarbital, saccharin, and benzoylperoxide had no measurable effect when added in concentrations known to affect in vitro two-step transformation or intercellular c...

journal_title：Cell biology and toxicology

authors： Verschueren H

更新日期：1985-06-01 00:00:00

abstract：:The development of nontoxic but effective radioprotectors is needed because of the increasing risk of human exposure to ionizing radiation. We have reported that alpha-lipoic acid confers considerable radio-protective effect in mouse tissues when given prior to x-irradiation. In the present study, alpha-lipoic acid su...

journal_title：Cell biology and toxicology

authors： Manda K,Ueno M,Moritake T,Anzai K

更新日期：2007-03-01 00:00:00

abstract：:RANTES is a chemokine with eosinophil attractant and activating activities. This study was undertaken to determine whether primary cultures of human nasal and primate bronchial epithelial cells produce RANTES and the effect of various cytokines and dexamethasone on the release of this chemokine. Nasal epithelial cells...

journal_title：Cell biology and toxicology

authors： Altman GB,Altman LC,Luchtel DL,Jabbour AJ,Baker C

更新日期：1997-03-01 00:00:00