Inhibition of apoptosis by menadione on exposure to UVA.

abstract：:The activity of chemical-induced unscheduled DNA synthesis was evaluated in hepatocyte primary cultures from Fischer 344 and Sprague-Dawley rats over a period of two years. In this two-year study hepatocytes from both sexes and strains were prepared from animals 2, 8, 14, 20 and 25 months of age and UDS was measured b...

journal_title：Cell biology and toxicology

authors： Probst GS,Hill LE

更新日期：1987-06-01 00:00:00

abstract：:Generating large amounts of recombinant protein in transgenic animals is often challenging and has a number of drawbacks compared to cell culture systems. The baculovirus expression vector system (BEVS) uses virus-infected insect cells to produce recombinant proteins to high levels, and these are usually processed in ...

journal_title：Cell biology and toxicology

authors： Hitchman RB,Possee RD,Crombie AT,Chambers A,Ho K,Siaterli E,Lissina O,Sternard H,Novy R,Loomis K,Bird LE,Owens RJ,King LA

更新日期：2010-02-01 00:00:00

abstract：:Cellular accumulation of mono(2-ethylhexyl)phthalate (MEHP) has been recently demonstrated to disturb fat cell energy metabolism; however, the underlying mechanism remained unclear. The study aimed to determine how MEHP influenced fat cell transcriptome and how the changes might contribute to bioenergetics. Because of...

journal_title：Cell biology and toxicology

authors： Chiang HC,Wang CH,Yeh SC,Lin YH,Kuo YT,Liao CW,Tsai FY,Lin WY,Chuang WH,Tsou TC

更新日期：2017-12-01 00:00:00

abstract：:During the last few years the increased presence of proinflammatory cytokines and oxidation products in Alzheimer's disease (AD) has been largely described. Oxysterols, formed by hydroxylation of cholesterol, occur naturally in the brain and are increased in the serum of AD patients. Of these oxysterols, 25-hydroxycho...

journal_title：Cell biology and toxicology

authors： Gueguen Y,Bertrand P,Ferrari L,Batt AM,Siest G

更新日期：2001-01-01 00:00:00

abstract：:The nephrotoxic fungal toxins ochratoxin A (OA), ochratoxin B (OB) and citrinin (CIT) are natural contaminants of foods and feeds. While cytotoxicity assays have proven useful for establishing relative toxicity and structure function relationships within groups of fungal toxins, a drawback of in vitro bioassays is the...

journal_title：Cell biology and toxicology

authors： Bondy GS,Armstrong CL

更新日期：1998-10-01 00:00:00

abstract：:Inhibition of endosomal acidification disturbs insulin signaling in both liver and adipose cells. In this study we used MIN6 beta cells to determine whether bafilomycin, a potent inhibitor of the proton-translocating vacuolar ATPase, disrupts insulin signaling in islet beta cells. Pretreatment of MIN6 cells with varyi...

journal_title：Cell biology and toxicology

authors： Hettiarachchi KD,Zimmet PZ,Myers MA

更新日期：2006-05-01 00:00:00

abstract：:We present a simple, noninvasive, nondestructive all-purpose method for the quantitative evaluation of functional effects of xenobiotics with cultured cells and the work station for its routine, easy implementation. At present 1 to 150 cells growing in one to six dishes can be studied in parallel or otherwise at time ...

journal_title：Cell biology and toxicology

authors： Lees D,Pugnère D,Castel A,Raux O,Travo P

更新日期：1994-12-01 00:00:00

abstract：:Harmful algal blooms (HABs) can have both lethal and sublethal impacts on shellfish. To understand the possible roles of haemocytes in bivalve immune responses to HABs and how the algae are affected by these cells (haemocytes), in vitro tests between cultured harmful algal species and haemocytes of the northern quahog...

journal_title：Cell biology and toxicology

authors： Hégaret H,da Silva PM,Wikfors GH,Haberkorn H,Shumway SE,Soudant P

更新日期：2011-08-01 00:00:00

abstract：:Adverse effect of nanoparticles may include impairment of phagocyte function. To identify the effect of nanoparticle size on uptake, cytotoxicity, chemotaxis, cytokine secretion, phagocytosis, oxidative burst, nitric oxide production and myeloperoxidase release, leukocytes isolated from human peripheral blood, monocyt...

journal_title：Cell biology and toxicology

authors： Prietl B,Meindl C,Roblegg E,Pieber TR,Lanzer G,Fröhlich E

更新日期：2014-02-01 00:00:00

abstract：:The culture of rabbit tenocytes could be a useful model in the study of the physiopathology and pharmacotoxicology of tendons. This work was undertaken to examine the in vitro behavior of tenocytes form juvenile rabbit Achilles tendons. We report observations of the morphological and biological characteristics of prim...

journal_title：Cell biology and toxicology

authors： Bernard-Beaubois K,Hecquet C,Houcine O,Hayem G,Adolphe M

更新日期：1997-02-01 00:00:00

abstract：:The piperidine nitroxides Tempamine and Tempace have been studied for their effect on doxorubicin (DOX) and hydrogen peroxide (H(2)O(2)) cytotoxicity in immortalized B14 cells, a model for neoplastic phenotype. The significance for nitroxide performance of the substituent in position 4 of the piperidine ring was evalu...

journal_title：Cell biology and toxicology

authors： Czepas J,Koceva-Chyła A,Gwoździński K,Jóźwiak Z

更新日期：2008-01-01 00:00:00

abstract：:During the last decade, the unbound glutathione content of cultured adherent cells has become a very important biological marker for many pharmacological and toxicological in vitro studies with regard to the protective role of the tripeptide in its reduced form (GSH). However, the literature does not provide extensive...

journal_title：Cell biology and toxicology

authors： Thioudellet C,Oster T,Leroy P,Nicolas A,Wellman M

更新日期：1995-04-01 00:00:00

abstract：:Oxidative cell injury could be induced by different reactive oxygen species (ROS) operating in multiple pathways. The present work is focused on three different models of oxidative stress: the xanthine/xanthine oxidase system (XXO), an extracellular superoxide anion generator; tert-butylhydroperoxide (TBHP), an analog...

journal_title：Cell biology and toxicology

authors： Fernandes AS,Serejo J,Gaspar J,Cabral F,Bettencourt AF,Rueff J,Castro M,Costa J,Oliveira NG

更新日期：2010-04-01 00:00:00

abstract：:The mutagenic activity of the pyrolysis products 2-amino-3-methyl-imidazo[4,5-f]-quinoline 2-amino-3,4-dimethylimidazo[4,5-f]-quinoline in Salmonella typhimurium TA98 using rat intestinal and renal subcellular fractions as activation systems was approximately 1 and 5 revertants per nmol, respectively. This was 1,000 t...

journal_title：Cell biology and toxicology

authors： Holme JA,Alexander J,Dybing E

更新日期：1987-03-01 00:00:00

abstract：:Although the interactions of sulfur mustard (HD) with nucleic acids and proteins have been well studied, the toxic interactions with the membrane matrix and specially the phospholipid bilayer have so far been poorly investigated. We have used several NMR techniques to study these interactions: 1H NMR to observe the lo...

journal_title：Cell biology and toxicology

authors： Debouzy JC,Aous S,Dabouis V,Neveux Y,Gentilhomme E

更新日期：2002-01-01 00:00:00

abstract：:New developments in mutagenic risk assessment have appeared in the past few years. New methods have been developed such as in vitro micronucleus assay for chromosomal alterations, comet assay for primary DNA damage, use of transgenic animals to detect in vivo gene mutations, and fluorescent in situ hybridization metho...

journal_title：Cell biology and toxicology

authors： Marzin D

更新日期：1999-01-01 00:00:00

abstract：:Bisnaphthalimido compounds bis-intercalate to DNA via the major groove and are potentially potent cancer therapeutics. Previously, we incorporated natural polyamines as linkers connecting the two naphthalimido ring moieties to create a series of soluble bisnaphthalimidopropyl polyamines (BNIPPs). Here, extending earli...

journal_title：Cell biology and toxicology

authors： Bestwick CS,Ralton LD,Milne L,Kong Thoo Lin P,Duthie SJ

更新日期：2011-12-01 00:00:00

abstract：:Uranium is a natural radioactive metallic element; its effect on the organism is cumulative, and chronic exposure to this element can induce carcinogenesis. Three cities of the Amazon region-Monte Alegre, Prainha, and Alenquer-in North Brazil, are located in one of the largest uranium mineralization areas of the world...

journal_title：Cell biology and toxicology

authors： Guimarães AC,Antunes LM,Ribeiro HF,dos Santos AK,Cardoso PC,de Lima PL,Seabra AD,Pontes TB,Pessoa C,de Moraes MO,Cavalcanti BC,Sombra CM,Bahia Mde O,Burbano RR

更新日期：2010-10-01 00:00:00

abstract：:The histopathological response and cell culture characteristics of liver cells from the R16 (grc-) strain of rats, which carries an MHC-linked deletion, were examined one week after a single intraperitoneal injection of 200 mg/kg body weight diethylnitrosamine (DEN) and were compared with the response of liver cells f...

journal_title：Cell biology and toxicology

authors： Smith GJ,Kunz HW,Dunsford HA,Gill TJ 3rd

更新日期：1990-04-01 00:00:00

abstract：:The heat-stable enterotoxin (Y-STa) produced by the pathogenic strains of Yersinia enterocolitica is a causative agent of secretory diarrhea. We have reported earlier that Y-STa-induced inositol trisphosphate-mediated cytosolic calcium rise occurs in rat intestinal epithelial cells. In the present communication, the i...

journal_title：Cell biology and toxicology

authors： Saha S,Chowdhury P,Mazumdar A,Pal A,Das P,Chakrabarti MK

更新日期：2009-06-01 00:00:00

abstract：:Knowledge of the acute toxic effects of chemicals is important for the protection of exposed humans. Since sufficient information in humans is often lacking, experiments on laboratory animals must be performed. The LD50 test, which requires large numbers of animals, has become the preferred procedure. It is now widely...

journal_title：Cell biology and toxicology

authors： Zbinden G

更新日期：1986-09-01 00:00:00

abstract：:In pharmaceutical research, in vitro toxicity tests, for assessing the potential toxicity of new chemical entities are necessary in the early stages of the developmental process, when no information is available about the metabolism or even the target organ toxicity of the compounds to be tested. In vitro specific org...

journal_title：Cell biology and toxicology

authors： Negro GD,Bonato M,Gribaldo L

更新日期：2001-01-01 00:00:00

abstract：:Sensitivity of baker's yeast to disulfiram (DSF) and hypersensitivity of a mutant devoid of Cu, Zn-superoxide dismutase to this compound is reported, demonstrating that yeast may be a simple convenient eukaryotic model to study the mechanism of DSF toxicity. DSF was found to induce oxidative stress in yeast cells demo...

journal_title：Cell biology and toxicology

authors： Kwolek-Mirek M,Zadrag-Tecza R,Bartosz G

更新日期：2012-02-01 00:00:00

abstract：:We assessed the in vitro toxicity of various particles on three murine macrophage cell lines, (J774A.1, WR19M.1, RAW264.7). The cells were exposed to aqueous suspensions (0-100 microg/30 mm2 well) of urban particulate matter (SRM-1648, SRM-1649, EHC-93), fine particulate matter (PM2.5), titanium dioxide (SRM-154b), an...

journal_title：Cell biology and toxicology

authors： Chauhan V,Breznan D,Goegan P,Nadeau D,Karthikeyan S,Brook JR,Vincent R

更新日期：2004-07-01 00:00:00

abstract：:We have previously synthesized various diazenecarboxamides (subsequently referred to as diazenes) that were cytotoxic to several tumor cell lines. To increase their biological activity, the structure has been modified appropriately. In the present study we examined the effects of N(1)-phenyl-N(2)-(2-pyridinylmethyl)di...

journal_title：Cell biology and toxicology

authors： Jakopec S,Dubravcic K,Brozovic A,Polanc S,Osmak M

更新日期：2006-01-01 00:00:00

abstract：:Cerebral infarction causes severe morbidity and mortality. Most patients with cerebral infarction should take antiplatelet drugs daily, so the effects of those drugs on the regeneration of the brain need to be investigated. Aspirin and clopidogrel are the most widely used antiplatelet drugs for the prevention of ische...

journal_title：Cell biology and toxicology

authors： Hwang M,Park HH,Choi H,Lee KY,Lee YJ,Koh SH

更新日期：2018-06-01 00:00:00

abstract：:Many of the differentiated functions of hepatocytes are lost in culture, yet addition of certain medium supplements can aid in the retention of differentiated character. Therefore, the effect of time in monolayer culture on rat hepatocyte glutathione (GSH) synthesis and sensitivity to the GSH detoxicated xenobiotic et...

journal_title：Cell biology and toxicology

authors： Meredith MJ

更新日期：1986-12-01 00:00:00

abstract：:In order to assess cigarette smoke-induced oxidative damage to intact cells, an assay was developed to measure cell detachment and protection. Due to the complex nature of cigarette smoke, which contains molecules that can interfere with conventional spectrophotometric and fluorometric biochemical assays, transformed ...

journal_title：Cell biology and toxicology

authors： Pelle E,Ingrassia M,Mammone T,Marenus K,Maes D

更新日期：1998-08-01 00:00:00

abstract：:Echinoderms are valuable test species in marine ecotoxicology and offer a wide range of biological processes appropriate for this approach. Regenerating echinoderms can be regarded as amenable experimental models for testing the effects of exposure to contaminants, particularly endocrine disrupter compounds (EDCs). As...

journal_title：Cell biology and toxicology

authors： Sugni M,Manno V,Barbaglio A,Mozzi D,Bonasoro F,Tremolada P,Candia Carnevali MD

更新日期：2008-12-01 00:00:00

abstract：:Reciprocal interactions between tumor cells and endothelial cells constitute the most important stage of tumor metastasis. There is growing evidence suggesting that beta-estradiol and vitamin D modulate the progression of steroid-sensitive breast cancers. In keeping with those results, the purpose of the study reporte...

journal_title：Cell biology and toxicology

authors： Paduch R,Kandefer-Szerszeń M

更新日期：2005-09-01 00:00:00