Ascorbate and thiol antioxidants abolish sensitivity of yeast Saccharomyces cerevisiae to disulfiram.

abstract：:We compared the effects of four quaternary benzo[c]phenanthridine alkaloids--chelerythrine, chelilutine, sanguinarine, and sanguilutine--and two quaternary protoberberine alkaloids-berberine and coptisine--on the human cell line HeLa (cervix carcinoma cells) and the yeasts Saccharomyces cerevisiae and Schizosaccharomy...

journal_title：Cell biology and toxicology

authors： Slaninová I,Táborská E,Bochoráková H,Slanina J

更新日期：2001-01-01 00:00:00

abstract：:The effectiveness of some chelating agents to mobilize cadmium from Chinese hamster ovary cells after chronic exposure (20 hr), as well as from cytosolic metallothionein, was studied. In the first protocol, the most effective substance was 2,3-dimercaptopropanol, followed by 2,3-dimercaptopropane-1-sulfonate and 2,3-d...

journal_title：Cell biology and toxicology

authors： Rau W,Planas-Bohne F,Taylor DM

更新日期：1989-01-01 00:00:00

abstract：:Cyclosporin A induces in vivo a severe nephrotoxicity characterized by a large decrease in renal hemodynamics. The aim of this study is to establish the ability of the known NO donor 3-morpholinosydnonimine (SIN-1) to prevent the cyclosporin A-induced contraction by using rat isolated glomeruli and cultured glomerular...

journal_title：Cell biology and toxicology

authors： Potier M,Winicki J,Cambar J

更新日期：1996-12-01 00:00:00

abstract：:Aging, injuries, and diseases can be considered as the result of malfunctioning or damaged cells. Regenerative medicine aims to restore tissue homeostasis by repairing or replacing cells, tissues, or damaged organs, by linking and combining different disciplines including engineering, technology, biology, and medicine...

journal_title：Cell biology and toxicology

authors： Mora C,Serzanti M,Consiglio A,Memo M,Dell'Era P

更新日期：2017-08-01 00:00:00

abstract：:A method for the primary culture of rat liver cells on collagen-coated dextran microcarriers is described. Ethoxycoumarin deethylase (EOD) activity 24 hr after inoculation was comparable for liver cells cultured on microcarriers and on collagen-coated dishes. Cells were cultured on microcarriers for up to 48 hr and re...

journal_title：Cell biology and toxicology

authors： Voss JU,Seibert H

更新日期：1991-10-01 00:00:00

abstract：:Asiatic acid (AA), a triterpene, is known to be cytotoxic to several tumor cell lines. AA induces dose- and time-dependent cell death in U-87 MG human glioblastoma. This cell death occurs via both apoptosis and necrosis. The effect of AA may be cell type-specific as AA-induced cell death was mainly apoptotic in colon ...

journal_title：Cell biology and toxicology

authors： Cho CW,Choi DS,Cardone MH,Kim CW,Sinskey AJ,Rha C

更新日期：2006-11-01 00:00:00

abstract：:The heat-stable enterotoxin (Y-STa) produced by the pathogenic strains of Yersinia enterocolitica is a causative agent of secretory diarrhea. We have reported earlier that Y-STa-induced inositol trisphosphate-mediated cytosolic calcium rise occurs in rat intestinal epithelial cells. In the present communication, the i...

journal_title：Cell biology and toxicology

authors： Saha S,Chowdhury P,Mazumdar A,Pal A,Das P,Chakrabarti MK

更新日期：2009-06-01 00:00:00

abstract：:During the last few years the increased presence of proinflammatory cytokines and oxidation products in Alzheimer's disease (AD) has been largely described. Oxysterols, formed by hydroxylation of cholesterol, occur naturally in the brain and are increased in the serum of AD patients. Of these oxysterols, 25-hydroxycho...

journal_title：Cell biology and toxicology

authors： Gueguen Y,Bertrand P,Ferrari L,Batt AM,Siest G

更新日期：2001-01-01 00:00:00

abstract：:The effect of noncytotoxic doses of argemone oil (AO) and butter yellow (BY), the common adulterants in edible oil, on free radical generation and signaling pathway for cell proliferation in primary cells of gall bladder (GB) was undertaken. AO and BY showed no cytotoxicity at 0.1 μl/ml and 0.1 μg/ml concentration, re...

journal_title：Cell biology and toxicology

authors： Mishra V,Ansari KM,Khanna R,Das M

更新日期：2012-06-01 00:00:00

abstract：:Ten years have passed since the first publication announcing the generation of induced pluripotent stem cells (iPSCs). Issues related to ethics, immune rejection, and cell availability seemed to be solved following this breakthrough. The development of iPSC technology allows advances in in vitro cell differentiation f...

journal_title：Cell biology and toxicology

authors： Paes BCMF,Moço PD,Pereira CG,Porto GS,de Sousa Russo EM,Reis LCJ,Covas DT,Picanço-Castro V

更新日期：2017-06-01 00:00:00

abstract：:In a comprehensive assessment of genotoxicity, sodium fluoride was evaluated in a battery of cellular tests providing different genetic end points and biotransformation capabilities. The tests included the following: rat hepatocyte primary culture/DNA repair assay, Salmonella typhimurium histidine locus reversion assa...

journal_title：Cell biology and toxicology

authors： Tong CC,McQueen CA,Brat SV,Williams GM

更新日期：1988-06-01 00:00:00

abstract：:DNA formulated into aggregates with polycationic reagents are referred to by a variety of terms including non-viral vectors, synthetic vectors, lipoplexes, polyplexes and more recently nanoparticles. The capacity for delivery of multiple genes, genomic-sized constructs and siRNA delivery, with a diversity of possible ...

journal_title：Cell biology and toxicology

authors： Hart SL

更新日期：2010-02-01 00:00:00

abstract：:Interactions between microtubules and filamentous actin (F-actin) are essential to many cellular processes, but their mechanisms are poorly understood. We investigated possible roles of the myosin family of proteins in the interactions between filamentous actin (F-actin) and microtubules of budding yeast Saccharomyces...

journal_title：Cell biology and toxicology

authors： Chon K,Hwang HS,Lee JH,Song K

更新日期：2001-01-01 00:00:00

abstract：:DNA methylation is catalyzed by a family of DNA methyltransferases (DNMTs) including the maintenance enzyme DNMT 1 and de novo methyltransferases DNMT 3a and DNMT 3b. Elevated levels of DNMTs have been found in cancer cells and in several types of human tumors. A polymorphism found in DNMT3b has been associated with i...

journal_title：Cell biology and toxicology

authors： Xiao Y,Word B,Starlard-Davenport A,Haefele A,Lyn-Cook BD,Hammons G

更新日期：2008-06-01 00:00:00

abstract：:Bolesatine, a glycoprotein from Boletus satanas Lenz, has previously been shown to be mitogenic in rat and human lymphocytes at very low concentrations, whereas higher concentrations inhibited protein synthesis in vitro and in several in vivo systems. The low concentrations (1-10 ng/ml) of bolesatine were shown to act...

journal_title：Cell biology and toxicology

authors： Ennamany R,Marzetto S,Saboureau D,Creppy EE

更新日期：1995-12-01 00:00:00

abstract：:This review summarizes the strategy of cellular immortalization based on the principle of targeted oncogenesis in transgenic mice, used to establish models of transimmortalized renal proximal tubule cells, referred to as PKSV-PCT and PKSV-PR-cells, and collecting duct principal cells, referred to as mpkCCD(cl4) cells....

journal_title：Cell biology and toxicology

authors： Chassin C,Bens M,Vandewalle A

更新日期：2007-07-01 00:00:00

abstract：:We investigated mitogen-activated protein kinase (MAPK) pathways as well as reactive oxygen species (ROS) in olaquindox-induced apoptosis. Exposure of HepG2 cells to olaquindox resulted in the phosphorylation of p38 MAPK and c-Jun N-terminal kinases (JNK). To confirm the role of p38 MAPK and JNK, HepG2 cells were pret...

journal_title：Cell biology and toxicology

authors： Zhao WX,Tang SS,Jin X,Zhang CM,Zhang T,Wang CC,Sun Y,Xiao XL

更新日期：2013-08-01 00:00:00

abstract：:Sea urchin embryos and larvae represent suitable model systems on where to investigate the effects of heavy metals on development and cell viability. Here, we tested the toxic effects of low (10(-12 )M), medium (10(-9 )M), and high (10(-6 )M) cadmium chloride concentrations, mimicking unpolluted, moderately and highly...

journal_title：Cell biology and toxicology

authors： Filosto S,Roccheri MC,Bonaventura R,Matranga V

更新日期：2008-12-01 00:00:00

abstract：:RANTES is a chemokine with eosinophil attractant and activating activities. This study was undertaken to determine whether primary cultures of human nasal and primate bronchial epithelial cells produce RANTES and the effect of various cytokines and dexamethasone on the release of this chemokine. Nasal epithelial cells...

journal_title：Cell biology and toxicology

authors： Altman GB,Altman LC,Luchtel DL,Jabbour AJ,Baker C

更新日期：1997-03-01 00:00:00

abstract：:Okadaic acid (OA), produced by dinoflagellates during harmful algal blooms (HAB), belongs to the Diarrheic Shellfish Poisoning toxins that cause gastrointestinal symptoms in humans after consumption. In the present work, Ruditapes decussatus haemocytes were selected to evaluate the effect of OA on cell viability, enzy...

journal_title：Cell biology and toxicology

authors： Prado-Alvarez M,Flórez-Barrós F,Méndez J,Fernandez-Tajes J

更新日期：2013-06-01 00:00:00

abstract：:The study investigates the effect of fenugreek seed polyphenol extract (FPEt) on ethanol-induced damage in rat liver. Chronic ethanol administration (6 g kg(-1) day(-1) x 60 days) caused liver damage that was manifested by excessive formation of thiobarbituric-acid-reactive substances, lipid hydroperoxides, and conjug...

journal_title：Cell biology and toxicology

authors： Kaviarasan S,Sundarapandiyan R,Anuradha CV

更新日期：2008-10-01 00:00:00

abstract：:The mutation rates of tumor suppressor protein p53 gene (TP53) are high in lung adenocarcinoma and promote the development of acquired drug resistance. The present study evaluated the p53-dependent role in lung cancer cell sensitivity to PI3K-specific inhibitors, PI3K-associated inhibitors, PI3K-non-related inhibitors...

journal_title：Cell biology and toxicology

authors： Hou J,Cao X,Cheng Y,Wang X

更新日期：2020-10-01 00:00:00

abstract：:Metolachlor, a commonly used herbicide in the Midwestern USA, functions by inhibiting chlorophyll and protein synthesis in target plants. Herbicide exposure has led to detrimental effects in several organisms, affecting their growth and behavior; however, its mechanism of action in nontarget organisms is not yet clear...

journal_title：Cell biology and toxicology

authors： Lowry DM,Greiner D,Fretheim M,Ubben M,Dhanwada KR

更新日期：2013-08-01 00:00:00

abstract：:Many of the differentiated functions of hepatocytes are lost in culture, yet addition of certain medium supplements can aid in the retention of differentiated character. Therefore, the effect of time in monolayer culture on rat hepatocyte glutathione (GSH) synthesis and sensitivity to the GSH detoxicated xenobiotic et...

journal_title：Cell biology and toxicology

authors： Meredith MJ

更新日期：1986-12-01 00:00:00

abstract：:To determine the toxicological effects of complex mixtures of pesticides, we obtained data on 100 pesticide residues in common foods of central Italy. Fifteen pesticides were more regularly detected at higher levels (dithiocarbamates, benomyl/carbendazim, thiabendazole, diphenylamine, chlorthalonil, procymidone, fenar...

journal_title：Cell biology and toxicology

authors： Dolara P,Vezzani A,Caderni G,Coppi C,Torricelli F

更新日期：1993-10-01 00:00:00

abstract：:Because sodium fluoride (NaF) is widely used for prevention of dental caries, pathobiological effects of NaF were investigated on human oral mucosal fibroblasts. The results showed that NaF was cytotoxic to oral mucosal fibroblasts at concentrations of 4 mmol/L or higher. Exposure of cells to NaF for 2 h also inhibite...

journal_title：Cell biology and toxicology

authors： Jeng JH,Hsieh CC,Lan WH,Chang MC,Lin SK,Hahn LJ,Kuo MY

更新日期：1998-12-01 00:00:00

abstract：:Folic acid (FA) is a vitamin essential for normal cellular functions, growth, and development. Because humans cannot synthesize this micronutrient, it must be obtained from dietary sources through intestinal absorption. The intestinal tract is a major target for oxidative stress. Our aim was to investigate the effect ...

journal_title：Cell biology and toxicology

authors： Couto MR,Gonçalves P,Catarino T,Araújo JR,Correia-Branco A,Martel F

更新日期：2012-12-01 00:00:00

abstract：:New developments in mutagenic risk assessment have appeared in the past few years. New methods have been developed such as in vitro micronucleus assay for chromosomal alterations, comet assay for primary DNA damage, use of transgenic animals to detect in vivo gene mutations, and fluorescent in situ hybridization metho...

journal_title：Cell biology and toxicology

authors： Marzin D

更新日期：1999-01-01 00:00:00

abstract：:Galectin 3 (Gal-3) is upregulated in gastric epithelial cells as a host response to Helicobacter pylori infection. However, the significance of Gal-3 expression in H. pylori-infected cells is not well established. We analyzed Gal-3 intracellular expression, localization, and its effects in H. pylori-infected gastric e...

journal_title：Cell biology and toxicology

authors： Subhash VV,Ho B

更新日期：2016-02-01 00:00:00

abstract：:Because of a possible role of astrocytes in trialkyltin-induced neurotoxicity in vivo various studies have been performed using cultures of astrocytes or glioma cells in vitro. With respect to cytotoxic potencies of trialkyltins these studies gave rather divergent results. Therefore the aim of the present study was to...

journal_title：Cell biology and toxicology

authors： Seibert H,Mörchel S,Gülden M

更新日期：2004-09-01 00:00:00