Culture duration alters the glutathione content and sensitivity to ethacrynic acid of rat hepatocyte monolayer cultures.

abstract：:Reciprocal interactions between tumor cells and endothelial cells constitute the most important stage of tumor metastasis. There is growing evidence suggesting that beta-estradiol and vitamin D modulate the progression of steroid-sensitive breast cancers. In keeping with those results, the purpose of the study reporte...

journal_title：Cell biology and toxicology

authors： Paduch R,Kandefer-Szerszeń M

更新日期：2005-09-01 00:00:00

abstract：:The response of fatty liver to stress conditions (t-butyl hydroperoxide [t-BH] or 36 h of fasting) was investigated by assessing intracellular glutathione (GSH) compartmentation and redox status, GSH peroxidase (GSH-Px) and reductase (GSSG-Rx) activities, lipid peroxidation (TBARs) and serum ALT levels in rats on a ch...

journal_title：Cell biology and toxicology

authors： Grattagliano I,Caraceni P,Portincasa P,Domenicali M,Palmieri VO,Trevisani F,Bernardi M,Palasciano G

更新日期：2003-11-01 00:00:00

abstract：:The lethal toxin of Bacillus anthracis, which is composed of two separate proteinaceous exotoxins, namely protective antigen and lethal factor, is central to the pathogenesis of anthrax. Low levels of this toxin are known to induce release of cytokines such as tumor necrosis factor alpha (TNF-alpha). In the present st...

journal_title：Cell biology and toxicology

authors： Shin S,Hur GH,Kim YB,Yeon GB,Park KJ,Park YM,Lee WS

更新日期：2000-01-01 00:00:00

abstract：:Various in vitro preparations have been utilized to study the cellular activity of vasoactive agents on renal cortical microvessels and on mesangial cells. The receptors and the transduction pathways of bradykinin and atrial natriuretic factor were characterized on cultured cortical vascular smooth muscle cells from t...

journal_title：Cell biology and toxicology

authors： Essig M,Ledoux S,Tharaux PL,Chatziantoniou C,Dussaule JC

更新日期：1996-12-01 00:00:00

abstract：:Bisnaphthalimido compounds bis-intercalate to DNA via the major groove and are potentially potent cancer therapeutics. Previously, we incorporated natural polyamines as linkers connecting the two naphthalimido ring moieties to create a series of soluble bisnaphthalimidopropyl polyamines (BNIPPs). Here, extending earli...

journal_title：Cell biology and toxicology

authors： Bestwick CS,Ralton LD,Milne L,Kong Thoo Lin P,Duthie SJ

更新日期：2011-12-01 00:00:00

abstract：:Rats chronically exposed to acrylonitrile (ACN) have shown a dose-dependent increase in the incidence of astrocytomas in the brain. The mechanism(s) by which ACN induces cancer in rodents has not been established. ACN does not appear to be directly genotoxic in the brain and thus a nongenotoxic mode of action has been...

journal_title：Cell biology and toxicology

authors： Kamendulis LM,Jiang J,Zhang H,deFeijter-Rupp H,Trosko JE,Klaunig JE

更新日期：1999-06-01 00:00:00

abstract：:The kinetic parameters of inhibition of camel retinal acetylcholinesterase (AChE) activity by cycloheximide (CH) were investigated. For the control system, the Michaelis-Menten constant (K(m)) for the hydrolysis of acetylthiocholine iodide was found to be 0.076 mmol/L and the Vmax was 0.547 mumol/min per mg protein. I...

journal_title：Cell biology and toxicology

authors： al-Jafari AA,Kamal MA,Alhomida AS

更新日期：1998-06-01 00:00:00

abstract：:This study was implemented to test the Episkin model of reconstructed epidermis in the evaluation of the efficacy of cosmetic or dermopharmaceutical products on cutaneous energy metabolism. The energy metabolism is evaluated by measuring the concentration of intracellular ATP by a method using an ultrasensitive biolum...

journal_title：Cell biology and toxicology

authors： Buche P,Violin L,Girard P

更新日期：1994-12-01 00:00:00

abstract：:RANTES is a chemokine with eosinophil attractant and activating activities. This study was undertaken to determine whether primary cultures of human nasal and primate bronchial epithelial cells produce RANTES and the effect of various cytokines and dexamethasone on the release of this chemokine. Nasal epithelial cells...

journal_title：Cell biology and toxicology

authors： Altman GB,Altman LC,Luchtel DL,Jabbour AJ,Baker C

更新日期：1997-03-01 00:00:00

abstract：:Microcystin-leucine-arginine (MC-LR) was produced by toxic cyanobacteria, which has been shown to have potent hepatotoxicity. Our previous study has proved that MC-LR were able to promote intrahepatic biliary epithelial cell excessive proliferation. However, the underlying mechanism is not yet entirely clarified. Here...

journal_title：Cell biology and toxicology

authors： Yan M,Gu S,Pan C,Chen Y,Han X

更新日期：2021-01-21 00:00:00

abstract：:In a number of adverse drug reactions leading to hepatotoxicity drug metabolism is thought to be involved by generation of reactive metabolites from nontoxic drugs. In this study, an in vitro assay was developed for measurement of the impact of metabolic activation of compound on the cytotoxicity toward a human hepati...

journal_title：Cell biology and toxicology

authors： Otto M,Hansen SH,Dalgaard L,Dubois J,Badolo L

更新日期：2008-01-01 00:00:00

abstract：:Cationic lipids are widely used for gene transfer in vitro and show promise as vectors for in vivo gene therapy applications. However, there is limited understanding of the cellular mechanisms involved in nonviral gene transfer. We investigated two major steps that could be limiting barriers to cationic lipid-mediated...

journal_title：Cell biology and toxicology

authors： Escriou V,Ciolina C,Helbling-Leclerc A,Wils P,Scherman D

更新日期：1998-03-01 00:00:00

abstract：:The effect of noncytotoxic doses of argemone oil (AO) and butter yellow (BY), the common adulterants in edible oil, on free radical generation and signaling pathway for cell proliferation in primary cells of gall bladder (GB) was undertaken. AO and BY showed no cytotoxicity at 0.1 μl/ml and 0.1 μg/ml concentration, re...

journal_title：Cell biology and toxicology

authors： Mishra V,Ansari KM,Khanna R,Das M

更新日期：2012-06-01 00:00:00

abstract：:Lung cancer is one of the most common malignancies worldwide. Actinidia chinensis Planch root extract (acRoots) was found to have the capacity of the anti-tumor, although the molecular mechanisms remain unclear. The present study aims to investigate the molecular mechanisms by which lung cancer cells sense to inhibito...

journal_title：Cell biology and toxicology

authors： Lv J,Wang L,Shen H,Wang X

更新日期：2018-06-01 00:00:00

abstract：:Two human hepatoma cell lines, KYN-2 and Mz-Hep-1 were characterized in terms of glucuronidation capacity and inducibility of cytochrome P4501A1/1A2 and several UDP-glucuronosyltransferases (UGTs). Cytochrome P4501A1/1A2 activity was measured using 7-ethoxyresorufin and that of UGTs with 16 different substrates. The e...

journal_title：Cell biology and toxicology

authors： Abid A,Sabolovic N,Magdalou J

更新日期：1996-04-01 00:00:00

abstract：:DNA formulated into aggregates with polycationic reagents are referred to by a variety of terms including non-viral vectors, synthetic vectors, lipoplexes, polyplexes and more recently nanoparticles. The capacity for delivery of multiple genes, genomic-sized constructs and siRNA delivery, with a diversity of possible ...

journal_title：Cell biology and toxicology

authors： Hart SL

更新日期：2010-02-01 00:00:00

abstract：:The effects of the oxidizing agent t-butylhydroperoxide (t-BHP) were investigated on three human cell lines of different origin and growth features (A431 epithelial cells, ADF astrocytoma cells and U937 leukemic cells) using electron microscopy and electron paramagnetic resonance spectroscopy. The results indicate tha...

journal_title：Cell biology and toxicology

authors： Malorni W,Rainaldi G,Rivabene R,Santini MT

更新日期：1994-08-01 00:00:00

abstract：:Bolesatine, a glycoprotein from Boletus satanas Lenz, has previously been shown to be mitogenic in rat and human lymphocytes at very low concentrations, whereas higher concentrations inhibited protein synthesis in vitro and in several in vivo systems. The low concentrations (1-10 ng/ml) of bolesatine were shown to act...

journal_title：Cell biology and toxicology

authors： Ennamany R,Marzetto S,Saboureau D,Creppy EE

更新日期：1995-12-01 00:00:00

abstract：:Recent studies have demonstrated that the insecticide DDT is a tumor promoting agent. Similar to many other tumor promoting agents, DDT has been shown to inhibit gap junctional intercellular communication (GJIC) between cells in culture, and it has been suggested that DDT-induced loss of communication between adjacent...

journal_title：Cell biology and toxicology

authors： Fransson R,Nicotera P,Wärngård L,Ahlborg UG

更新日期：1990-04-01 00:00:00

abstract：:In previous studies cadmium chloride (CdCl2) nonlethally inhibited Y-1 adrenal mouse adrenal tumour cell 20-dihydroxyprogesterone (20DHP) secretion, affecting unstimulated and stimulated steroidogenic pathway sites differently. We studied CdCl2 effects on unstimulated steroidogenesis using Y-1 cells incubated 0.5 h in...

journal_title：Cell biology and toxicology

authors： Mgbonyebi OP,Smothers CT,Mrotek JJ

更新日期：1994-02-01 00:00:00

abstract：:Cyclosporin A induces in vivo a severe nephrotoxicity characterized by a large decrease in renal hemodynamics. The aim of this study is to establish the ability of the known NO donor 3-morpholinosydnonimine (SIN-1) to prevent the cyclosporin A-induced contraction by using rat isolated glomeruli and cultured glomerular...

journal_title：Cell biology and toxicology

authors： Potier M,Winicki J,Cambar J

更新日期：1996-12-01 00:00:00

abstract：:2,2'-Dichlorodiethyl sulfide (sulfur mustard, HD, 1,1'-thiobis [2-chloroethane]) is a potent vesicant which can cause severe lesions to skin, lung, and eyes. Due to the high number of debilitating exposures during the Iran-Iraq war to the alkylating agent, HD, there is an increased interest in its mechanism of action ...

journal_title：Cell biology and toxicology

authors： Meier HL

更新日期：1996-06-01 00:00:00

abstract：:Health risks associated with the inhalation of potentially toxic materials have been a topic of great public concern. In vitro cellular analyses can provide mechanistic information on the molecular-level responses of lung-derived cell lines to a variety of these hazards. This understanding may be used to develop metho...

journal_title：Cell biology and toxicology

authors： Boesewetter DE,Collier JL,Kim AM,Riley MR

更新日期：2006-03-01 00:00:00

abstract：:Recepteur d'origine nantais (RON) has been implicated in cell proliferation, metastasis, and chemoresistance of various human malignancies. The short-form RON (sf-RON) encoded by RON transcripts was overexpressed in gastric cancer tissues, but its regulatory functions remain illustrated. Here, we found that sf-RON pro...

journal_title：Cell biology and toxicology

authors： Wang Z,Yang Y,Hu S,He J,Wu Z,Qi Z,Huang M,Liu R,Lin Y,Tan C,Xu M,Zhang Z

更新日期：2021-02-01 00:00:00

abstract：:In pharmaceutical research, in vitro toxicity tests, for assessing the potential toxicity of new chemical entities are necessary in the early stages of the developmental process, when no information is available about the metabolism or even the target organ toxicity of the compounds to be tested. In vitro specific org...

journal_title：Cell biology and toxicology

authors： Negro GD,Bonato M,Gribaldo L

更新日期：2001-01-01 00:00:00

abstract：:Cellular accumulation of mono(2-ethylhexyl)phthalate (MEHP) has been recently demonstrated to disturb fat cell energy metabolism; however, the underlying mechanism remained unclear. The study aimed to determine how MEHP influenced fat cell transcriptome and how the changes might contribute to bioenergetics. Because of...

journal_title：Cell biology and toxicology

authors： Chiang HC,Wang CH,Yeh SC,Lin YH,Kuo YT,Liao CW,Tsai FY,Lin WY,Chuang WH,Tsou TC

更新日期：2017-12-01 00:00:00

abstract：:Sea urchin embryos and larvae represent suitable model systems on where to investigate the effects of heavy metals on development and cell viability. Here, we tested the toxic effects of low (10(-12 )M), medium (10(-9 )M), and high (10(-6 )M) cadmium chloride concentrations, mimicking unpolluted, moderately and highly...

journal_title：Cell biology and toxicology

authors： Filosto S,Roccheri MC,Bonaventura R,Matranga V

更新日期：2008-12-01 00:00:00

abstract：:Although the interactions of sulfur mustard (HD) with nucleic acids and proteins have been well studied, the toxic interactions with the membrane matrix and specially the phospholipid bilayer have so far been poorly investigated. We have used several NMR techniques to study these interactions: 1H NMR to observe the lo...

journal_title：Cell biology and toxicology

authors： Debouzy JC,Aous S,Dabouis V,Neveux Y,Gentilhomme E

更新日期：2002-01-01 00:00:00

abstract：:Ethanol consumption has long been associated with brain damage. However, the mechanism underlying this deleterious effect remains unclear. Among different hypotheses, acetaldehyde is regarded by certain authors as playing a major role in the expression of ethanol toxicity, but there are still some uncertainties about ...

journal_title：Cell biology and toxicology

authors： Lamarche F,Gonthier B,Signorini N,Eysseric H,Barret L

更新日期：2004-11-01 00:00:00

abstract：:Skin intoxication by bis(beta-chloroethyl)sulfide (BCES; sulfur mustard) induces cutaneous lesions similar to thermal burns, characterized by slowness of skin healing. We have developed an in vitro model of skin equivalent to investigate mechanisms involved in this delay. Direct intoxication of dermal equivalent produ...

journal_title：Cell biology and toxicology

authors： Gentilhomme E,Reano A,Pradel D,Bergier J,Schmitt D,Neveux Y

更新日期：1998-02-01 00:00:00