Quantitative evaluation of the effects of human carcinogens and related chemicals on human foreskin fibroblasts.

abstract：:This study was implemented to test the Episkin model of reconstructed epidermis in the evaluation of the efficacy of cosmetic or dermopharmaceutical products on cutaneous energy metabolism. The energy metabolism is evaluated by measuring the concentration of intracellular ATP by a method using an ultrasensitive biolum...

journal_title：Cell biology and toxicology

authors： Buche P,Violin L,Girard P

更新日期：1994-12-01 00:00:00

abstract：:Recent findings suggest a functional interaction of the drug resistance enzyme glutathione S-transferase P (GSTP) with the transcription factor Nrf2, a master regulator of the adaptive stress response to cellular electrophiles. The effect of this interaction on the metabolism and redox of cellular thiols was investiga...

journal_title：Cell biology and toxicology

authors： Bartolini D,Giustarini D,Pietrella D,Rossi R,Galli F

更新日期：2020-08-01 00:00:00

abstract：:Cerebral infarction causes severe morbidity and mortality. Most patients with cerebral infarction should take antiplatelet drugs daily, so the effects of those drugs on the regeneration of the brain need to be investigated. Aspirin and clopidogrel are the most widely used antiplatelet drugs for the prevention of ische...

journal_title：Cell biology and toxicology

authors： Hwang M,Park HH,Choi H,Lee KY,Lee YJ,Koh SH

更新日期：2018-06-01 00:00:00

abstract：:Asiatic acid (AA), a triterpene, is known to be cytotoxic to several tumor cell lines. AA induces dose- and time-dependent cell death in U-87 MG human glioblastoma. This cell death occurs via both apoptosis and necrosis. The effect of AA may be cell type-specific as AA-induced cell death was mainly apoptotic in colon ...

journal_title：Cell biology and toxicology

authors： Cho CW,Choi DS,Cardone MH,Kim CW,Sinskey AJ,Rha C

更新日期：2006-11-01 00:00:00

abstract：:The mouse skin cocarcinogens fluoranthene, pyrene, and undecane were used with the indirect-acting carcinogen, benzo(a)pyrene (BP), and the direct-acting alkylating carcinogen, beta-propiolactone (BPL), in an in vitro transformation assay. Dose response, cytotoxicity, and transformation studies with these compounds we...

journal_title：Cell biology and toxicology

authors： Atchison M,Atchison ML,Van Duuren BL

更新日期：1985-10-01 00:00:00

abstract：:In pharmaceutical research, in vitro toxicity tests, for assessing the potential toxicity of new chemical entities are necessary in the early stages of the developmental process, when no information is available about the metabolism or even the target organ toxicity of the compounds to be tested. In vitro specific org...

journal_title：Cell biology and toxicology

authors： Negro GD,Bonato M,Gribaldo L

更新日期：2001-01-01 00:00:00

abstract：:The lethal toxin of Bacillus anthracis, which is composed of two separate proteinaceous exotoxins, namely protective antigen and lethal factor, is central to the pathogenesis of anthrax. Low levels of this toxin are known to induce release of cytokines such as tumor necrosis factor alpha (TNF-alpha). In the present st...

journal_title：Cell biology and toxicology

authors： Shin S,Hur GH,Kim YB,Yeon GB,Park KJ,Park YM,Lee WS

更新日期：2000-01-01 00:00:00

abstract：:Ten years have passed since the first publication announcing the generation of induced pluripotent stem cells (iPSCs). Issues related to ethics, immune rejection, and cell availability seemed to be solved following this breakthrough. The development of iPSC technology allows advances in in vitro cell differentiation f...

journal_title：Cell biology and toxicology

authors： Paes BCMF,Moço PD,Pereira CG,Porto GS,de Sousa Russo EM,Reis LCJ,Covas DT,Picanço-Castro V

更新日期：2017-06-01 00:00:00

abstract：:We explored if epigenetic mechanisms could be involved in the down-regulated expression of catalase gene (CAT) in the doxorubicin-resistant acute myelogenous leukemia (AML)-2/DX100 cells. Down-regulated CAT expression in AML-2/DX100 cells was completely recovered after treatment of hydrogen peroxide (H(2)O(2)) and his...

journal_title：Cell biology and toxicology

authors： Lee TB,Moon YS,Choi CH

更新日期：2012-02-01 00:00:00

abstract：BACKGROUND AND AIMS:Endoplasmic reticulum (ER) stress is a growing concern for drug-induced toxicity which causes several side effects. Ritonavir, a potent HIV protease inhibitor, induces both ER and mitochondrial stress; however, the missing link between ER stress and mitochondrial damage has been unknown. In the pres...

journal_title：Cell biology and toxicology

authors： Ganta KK,Chaubey B

更新日期：2019-06-01 00:00:00

abstract：:DNA formulated into aggregates with polycationic reagents are referred to by a variety of terms including non-viral vectors, synthetic vectors, lipoplexes, polyplexes and more recently nanoparticles. The capacity for delivery of multiple genes, genomic-sized constructs and siRNA delivery, with a diversity of possible ...

journal_title：Cell biology and toxicology

authors： Hart SL

更新日期：2010-02-01 00:00:00

abstract：:Magnesium, an essential metal that is important in the normal functioning of DNA, has been shown to interact with some of the toxic heavy metals in respect to biochemical and molecular mechanisms and in altering the tumorigenic process. This study examined the influence of magnesium in combination with nickel and cadm...

journal_title：Cell biology and toxicology

authors： Littlefield NA,Hass BS,James SJ,Poirier LA

更新日期：1994-04-01 00:00:00

abstract：:Owing to the excellent antibacterial and antiviral activity, silver nanoparticles have a widespread use in the food and pharmaceutical industries. With the increase in the production and use of the related products, the potential hazard of silver nanoparticles has aroused public attention. The main purpose of this stu...

journal_title：Cell biology and toxicology

authors： Li L,Bi Z,Hu Y,Sun L,Song Y,Chen S,Mo F,Yang J,Wei Y,Wei X

更新日期：2020-05-04 00:00:00

abstract：:New developments in mutagenic risk assessment have appeared in the past few years. New methods have been developed such as in vitro micronucleus assay for chromosomal alterations, comet assay for primary DNA damage, use of transgenic animals to detect in vivo gene mutations, and fluorescent in situ hybridization metho...

journal_title：Cell biology and toxicology

authors： Marzin D

更新日期：1999-01-01 00:00:00

abstract：:The effectiveness of some chelating agents to mobilize cadmium from Chinese hamster ovary cells after chronic exposure (20 hr), as well as from cytosolic metallothionein, was studied. In the first protocol, the most effective substance was 2,3-dimercaptopropanol, followed by 2,3-dimercaptopropane-1-sulfonate and 2,3-d...

journal_title：Cell biology and toxicology

authors： Rau W,Planas-Bohne F,Taylor DM

更新日期：1989-01-01 00:00:00

abstract：:Bisnaphthalimido compounds bis-intercalate to DNA via the major groove and are potentially potent cancer therapeutics. Previously, we incorporated natural polyamines as linkers connecting the two naphthalimido ring moieties to create a series of soluble bisnaphthalimidopropyl polyamines (BNIPPs). Here, extending earli...

journal_title：Cell biology and toxicology

authors： Bestwick CS,Ralton LD,Milne L,Kong Thoo Lin P,Duthie SJ

更新日期：2011-12-01 00:00:00

abstract：:Various in vitro preparations have been utilized to study the cellular activity of vasoactive agents on renal cortical microvessels and on mesangial cells. The receptors and the transduction pathways of bradykinin and atrial natriuretic factor were characterized on cultured cortical vascular smooth muscle cells from t...

journal_title：Cell biology and toxicology

authors： Essig M,Ledoux S,Tharaux PL,Chatziantoniou C,Dussaule JC

更新日期：1996-12-01 00:00:00

abstract：:Harmful algal blooms (HABs) can have both lethal and sublethal impacts on shellfish. To understand the possible roles of haemocytes in bivalve immune responses to HABs and how the algae are affected by these cells (haemocytes), in vitro tests between cultured harmful algal species and haemocytes of the northern quahog...

journal_title：Cell biology and toxicology

authors： Hégaret H,da Silva PM,Wikfors GH,Haberkorn H,Shumway SE,Soudant P

更新日期：2011-08-01 00:00:00

abstract：:One of the major objectives at the end of this century is the development of "alternative" tests for the evaluation of the pharmacological and/or toxicological activity of newly developed molecules. Contact allergy is no exception to the rule and many research programs have been started to develop in vitro techniques ...

journal_title：Cell biology and toxicology

authors： Lepoittevin JP

更新日期：1999-02-01 00:00:00

abstract：:In the US alone, around 60,000 lives/year are lost to colon cancer. In order to study the mechanisms of colon carcinogenesis, in vitro model systems are required in addition to in vivo models. Towards this end, we have used the HT-29 colon cancer cells, cultured in Dulbecco's Modified Eagle Medium (DMEM), which were e...

journal_title：Cell biology and toxicology

authors： Myers JN,Harris KL,Rekhadevi PV,Pratap S,Ramesh A

更新日期：2021-01-07 00:00:00

abstract：:The risk presented by mycotoxins is a toxicological problem. As the data given by physico-chemical analysis may be difficult to translate in terms of toxicity, however, especially when considering multiple contamination, we have developed a system for toxicological analysis of mycotoxins using cell cultures of differe...

journal_title：Cell biology and toxicology

authors： Robbana-Barnat S,Lafarge-Frayssinet C,Frayssinet C

更新日期：1989-06-01 00:00:00

abstract：:Chrysotile is the predominant type of asbestos used in the United States and thus represents the most important source of exposure to asbestos already in place. While the steepest exposure-response observed for lung cancer has been in workers exposed to chrysotile in textile operations, some argue that chrysotile is l...

journal_title：Cell biology and toxicology

authors： Dement JM

更新日期：1991-01-01 00:00:00

abstract：:In a number of adverse drug reactions leading to hepatotoxicity drug metabolism is thought to be involved by generation of reactive metabolites from nontoxic drugs. In this study, an in vitro assay was developed for measurement of the impact of metabolic activation of compound on the cytotoxicity toward a human hepati...

journal_title：Cell biology and toxicology

authors： Otto M,Hansen SH,Dalgaard L,Dubois J,Badolo L

更新日期：2008-01-01 00:00:00

abstract：:Pulmonary alveolar macrophages exposed to very short chrysotile asbestos fibers present a typical cytotoxic response: extracellular releases of lactate dehydrogenase and beta-galactosidase, and a decrease in cellular ATP content. The objective of this study was to determine if nicotinamide and 3-aminobenzamide, two in...

journal_title：Cell biology and toxicology

authors： Nadeau D,Lane DA

更新日期：1988-03-01 00:00:00

abstract：:Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) as a serious event has high mortality and medical costs. Systemic inflammation and immune response are the major factors influencing the outcome and quality of patient with AECOPD. On basis of identification and validation of AECOPD-specific inflamma...

journal_title：Cell biology and toxicology

authors： Shi L,Zhu B,Xu M,Wang X

更新日期：2018-04-01 00:00:00

abstract：:Lung cancer is one of the most common malignancies worldwide. Actinidia chinensis Planch root extract (acRoots) was found to have the capacity of the anti-tumor, although the molecular mechanisms remain unclear. The present study aims to investigate the molecular mechanisms by which lung cancer cells sense to inhibito...

journal_title：Cell biology and toxicology

authors： Lv J,Wang L,Shen H,Wang X

更新日期：2018-06-01 00:00:00

abstract：:Generating large amounts of recombinant protein in transgenic animals is often challenging and has a number of drawbacks compared to cell culture systems. The baculovirus expression vector system (BEVS) uses virus-infected insect cells to produce recombinant proteins to high levels, and these are usually processed in ...

journal_title：Cell biology and toxicology

authors： Hitchman RB,Possee RD,Crombie AT,Chambers A,Ho K,Siaterli E,Lissina O,Sternard H,Novy R,Loomis K,Bird LE,Owens RJ,King LA

更新日期：2010-02-01 00:00:00

abstract：:Because sodium fluoride (NaF) is widely used for prevention of dental caries, pathobiological effects of NaF were investigated on human oral mucosal fibroblasts. The results showed that NaF was cytotoxic to oral mucosal fibroblasts at concentrations of 4 mmol/L or higher. Exposure of cells to NaF for 2 h also inhibite...

journal_title：Cell biology and toxicology

authors： Jeng JH,Hsieh CC,Lan WH,Chang MC,Lin SK,Hahn LJ,Kuo MY

更新日期：1998-12-01 00:00:00

abstract：:We present a simple, noninvasive, nondestructive all-purpose method for the quantitative evaluation of functional effects of xenobiotics with cultured cells and the work station for its routine, easy implementation. At present 1 to 150 cells growing in one to six dishes can be studied in parallel or otherwise at time ...

journal_title：Cell biology and toxicology

authors： Lees D,Pugnère D,Castel A,Raux O,Travo P

更新日期：1994-12-01 00:00:00

abstract：:Okadaic acid (OA), produced by dinoflagellates during harmful algal blooms (HAB), belongs to the Diarrheic Shellfish Poisoning toxins that cause gastrointestinal symptoms in humans after consumption. In the present work, Ruditapes decussatus haemocytes were selected to evaluate the effect of OA on cell viability, enzy...

journal_title：Cell biology and toxicology

authors： Prado-Alvarez M,Flórez-Barrós F,Méndez J,Fernandez-Tajes J

更新日期：2013-06-01 00:00:00