Olive leaf extract counteracts epithelial to mesenchymal transition process induced by peritoneal dialysis, through the inhibition of TGFβ1 signaling.

abstract：:In order to clarify the protective mechanism of sodium molybdate against the acute toxicity of cadmium chloride in rat, the effect of in vivo sodium molybdate pretreatment on the cytotoxic action of cadmium in isolated hepatocytes was studied. The cytosolic pH of hepatocytes isolated from untreated rats immediately de...

journal_title：Cell biology and toxicology

authors： Koizumi T,Yokota T,Fukuchi M,Tatsumoto H,Yamane Y

更新日期：1991-10-01 00:00:00

abstract：:Various in vitro preparations have been utilized to study the cellular activity of vasoactive agents on renal cortical microvessels and on mesangial cells. The receptors and the transduction pathways of bradykinin and atrial natriuretic factor were characterized on cultured cortical vascular smooth muscle cells from t...

journal_title：Cell biology and toxicology

authors： Essig M,Ledoux S,Tharaux PL,Chatziantoniou C,Dussaule JC

更新日期：1996-12-01 00:00:00

abstract：:During the last decade, the unbound glutathione content of cultured adherent cells has become a very important biological marker for many pharmacological and toxicological in vitro studies with regard to the protective role of the tripeptide in its reduced form (GSH). However, the literature does not provide extensive...

journal_title：Cell biology and toxicology

authors： Thioudellet C,Oster T,Leroy P,Nicolas A,Wellman M

更新日期：1995-04-01 00:00:00

abstract：:Recent findings suggest a functional interaction of the drug resistance enzyme glutathione S-transferase P (GSTP) with the transcription factor Nrf2, a master regulator of the adaptive stress response to cellular electrophiles. The effect of this interaction on the metabolism and redox of cellular thiols was investiga...

journal_title：Cell biology and toxicology

authors： Bartolini D,Giustarini D,Pietrella D,Rossi R,Galli F

更新日期：2020-08-01 00:00:00

abstract：:Male albino rats with diabetes induced by the administration of streptozotocin (STZ) (45 mg/kg, i.v.) were treated with oral administration of diphenyl diselenide (DPDS) pre-dissolved in soya bean oil. A significant reduction in blood glucose levels was observed in STZ-induced diabetic rats treated with DPDS compared ...

journal_title：Cell biology and toxicology

authors： Kade IJ,Borges VC,Savegnago L,Ibukun EO,Zeni G,Nogueira CW,Rocha JB

更新日期：2009-08-01 00:00:00

abstract：:Sister chromatid exchange rate was studied in 12 early diagnosed cases of nasopharyngeal carcinoma and in their paired controls. Exchange frequencies were also analyzed in 100 healthy subjects distributed in four regions of Hunan Province and correlated to nationality, age and sex. The incidence of sister chromatid ex...

journal_title：Cell biology and toxicology

authors： Hu YC,Li GY,Peng L,Deng YM

更新日期：1987-09-01 00:00:00

abstract：:In pharmaceutical research, in vitro toxicity tests, for assessing the potential toxicity of new chemical entities are necessary in the early stages of the developmental process, when no information is available about the metabolism or even the target organ toxicity of the compounds to be tested. In vitro specific org...

journal_title：Cell biology and toxicology

authors： Negro GD,Bonato M,Gribaldo L

更新日期：2001-01-01 00:00:00

abstract：:Health risks associated with the inhalation of potentially toxic materials have been a topic of great public concern. In vitro cellular analyses can provide mechanistic information on the molecular-level responses of lung-derived cell lines to a variety of these hazards. This understanding may be used to develop metho...

journal_title：Cell biology and toxicology

authors： Boesewetter DE,Collier JL,Kim AM,Riley MR

更新日期：2006-03-01 00:00:00

abstract：:Folic acid (FA) is a vitamin essential for normal cellular functions, growth, and development. Because humans cannot synthesize this micronutrient, it must be obtained from dietary sources through intestinal absorption. The intestinal tract is a major target for oxidative stress. Our aim was to investigate the effect ...

journal_title：Cell biology and toxicology

authors： Couto MR,Gonçalves P,Catarino T,Araújo JR,Correia-Branco A,Martel F

更新日期：2012-12-01 00:00:00

abstract：:Mechanisms of cell death induced by toxins probably involve one or more processes such as inhibition of protein synthesis and impairment of plasma membrane integrity leading to an increase in membrane permeability. Since one of the possible actions of mastoparan, a cationic tetradecapeptide from wasp venom, is to pert...

journal_title：Cell biology and toxicology

authors： Eng SP,Lo CS

更新日期：1990-01-01 00:00:00

abstract：:Previous studies showed that the pesticide lindane (gamma-hexachlorocyclohexane) inhibits gap junction intercellular communication in rat myometrial cells. The present study tested the hypothesis that lindane and the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) inhibit gap junction communication in rat myo...

journal_title：Cell biology and toxicology

authors： Loch-Caruso R,Galvez MM,Brant K,Chung D

更新日期：2004-05-01 00:00:00

abstract：:It has been well documented in in vitro studies that ambient airborne particulate matter (PM) with an aerodynamic diameter less than 2.5 μm (PM(2.5)) is capable of inducing oxidative stress, which plays a key role in PM(2.5)-mediated cytotoxicity. Although nuclear factor erythroid-2-related factor 2 (Nrf2) has been sh...

journal_title：Cell biology and toxicology

authors： Deng X,Rui W,Zhang F,Ding W

更新日期：2013-06-01 00:00:00

abstract：:Asiatic acid (AA), a triterpene, is known to be cytotoxic to several tumor cell lines. AA induces dose- and time-dependent cell death in U-87 MG human glioblastoma. This cell death occurs via both apoptosis and necrosis. The effect of AA may be cell type-specific as AA-induced cell death was mainly apoptotic in colon ...

journal_title：Cell biology and toxicology

authors： Cho CW,Choi DS,Cardone MH,Kim CW,Sinskey AJ,Rha C

更新日期：2006-11-01 00:00:00

abstract：:Based on the reduced expression of ethanol-oxidizing enzymes in human hepatocellular carcinoma (HepG2) cells, we analyzed the role of nonoxidative metabolites in ethanol-induced apoptosis in HepG2 cells. For this purpose, an analysis of volatile metabolites of ethanol using ion-mobility spectrometry and gas chromatogr...

journal_title：Cell biology and toxicology

authors： Castaneda F,Zimmermann D,Nolte J,Baumbach JI

更新日期：2007-11-01 00:00:00

abstract：:Two human hepatoma cell lines, KYN-2 and Mz-Hep-1 were characterized in terms of glucuronidation capacity and inducibility of cytochrome P4501A1/1A2 and several UDP-glucuronosyltransferases (UGTs). Cytochrome P4501A1/1A2 activity was measured using 7-ethoxyresorufin and that of UGTs with 16 different substrates. The e...

journal_title：Cell biology and toxicology

authors： Abid A,Sabolovic N,Magdalou J

更新日期：1996-04-01 00:00:00

abstract：:In vitro directional migration of 10T1/2 fibroblasts is partially inhibited by TPA but not by its non-promoting analogues. Other tumor promoters, e.g., phenobarbital, saccharin, and benzoylperoxide had no measurable effect when added in concentrations known to affect in vitro two-step transformation or intercellular c...

journal_title：Cell biology and toxicology

authors： Verschueren H

更新日期：1985-06-01 00:00:00

abstract：:Metolachlor, a commonly used herbicide in the Midwestern USA, functions by inhibiting chlorophyll and protein synthesis in target plants. Herbicide exposure has led to detrimental effects in several organisms, affecting their growth and behavior; however, its mechanism of action in nontarget organisms is not yet clear...

journal_title：Cell biology and toxicology

authors： Lowry DM,Greiner D,Fretheim M,Ubben M,Dhanwada KR

更新日期：2013-08-01 00:00:00

abstract：:A method for the primary culture of rat liver cells on collagen-coated dextran microcarriers is described. Ethoxycoumarin deethylase (EOD) activity 24 hr after inoculation was comparable for liver cells cultured on microcarriers and on collagen-coated dishes. Cells were cultured on microcarriers for up to 48 hr and re...

journal_title：Cell biology and toxicology

authors： Voss JU,Seibert H

更新日期：1991-10-01 00:00:00

abstract：:Knowledge of the acute toxic effects of chemicals is important for the protection of exposed humans. Since sufficient information in humans is often lacking, experiments on laboratory animals must be performed. The LD50 test, which requires large numbers of animals, has become the preferred procedure. It is now widely...

journal_title：Cell biology and toxicology

authors： Zbinden G

更新日期：1986-09-01 00:00:00

abstract：:Ethanol consumption has long been associated with brain damage. However, the mechanism underlying this deleterious effect remains unclear. Among different hypotheses, acetaldehyde is regarded by certain authors as playing a major role in the expression of ethanol toxicity, but there are still some uncertainties about ...

journal_title：Cell biology and toxicology

authors： Lamarche F,Gonthier B,Signorini N,Eysseric H,Barret L

更新日期：2004-11-01 00:00:00

abstract：:Echinoderms are valuable test species in marine ecotoxicology and offer a wide range of biological processes appropriate for this approach. Regenerating echinoderms can be regarded as amenable experimental models for testing the effects of exposure to contaminants, particularly endocrine disrupter compounds (EDCs). As...

journal_title：Cell biology and toxicology

authors： Sugni M,Manno V,Barbaglio A,Mozzi D,Bonasoro F,Tremolada P,Candia Carnevali MD

更新日期：2008-12-01 00:00:00

abstract：:The effect of noncytotoxic doses of argemone oil (AO) and butter yellow (BY), the common adulterants in edible oil, on free radical generation and signaling pathway for cell proliferation in primary cells of gall bladder (GB) was undertaken. AO and BY showed no cytotoxicity at 0.1 μl/ml and 0.1 μg/ml concentration, re...

journal_title：Cell biology and toxicology

authors： Mishra V,Ansari KM,Khanna R,Das M

更新日期：2012-06-01 00:00:00

abstract：:Ten compounds representative of diverse classes of chemicals were evaluated for their cytotoxicity and transforming ability to human skin fibroblasts in vitro. Only five of the ten compounds were highly cytotoxic in the 0-100 micrograms/ml range and their order of cytotoxicity was: 2,5-bis(1-aziridinyl)-3,6-bis(carboe...

journal_title：Cell biology and toxicology

authors： Kurian P,Nesnow S,Milo GE

更新日期：1990-04-01 00:00:00

abstract：:One of the major objectives at the end of this century is the development of "alternative" tests for the evaluation of the pharmacological and/or toxicological activity of newly developed molecules. Contact allergy is no exception to the rule and many research programs have been started to develop in vitro techniques ...

journal_title：Cell biology and toxicology

authors： Lepoittevin JP

更新日期：1999-02-01 00:00:00

abstract：:Ziram, a zinc dithiocarbamate is widely used worldwide as a fungicide in agriculture. In order to investigate ziram-induced changes in macrophage functions and polarization, human monocytes-derived macrophages in culture were treated with ziram at 0.01-10 μmol.L-1 for 4-24 h. To characterize zinc involvement in these ...

journal_title：Cell biology and toxicology

authors： Parny M,Bernad J,Prat M,Salon M,Aubouy A,Bonnafé E,Coste A,Pipy B,Treilhou M

更新日期：2020-07-25 00:00:00

abstract：:Transforming growth factor-beta1 (TGF-beta1) can activate mitogen-activated protein kinases (MAPKs) in many types of cells. The mechanism of this activation is not well elucidated. Here, we explore the role of TGF-beta/Smads signaling compounds in TGF-beta1-mediated activation of extracellular signal-regulated kinase ...

journal_title：Cell biology and toxicology

authors： Huo YY,Hu YC,He XR,Wang Y,Song BQ,Zhou PK,Zhu MX,Li G,Wu DC

更新日期：2007-03-01 00:00:00

abstract：:In a comprehensive assessment of genotoxicity, sodium fluoride was evaluated in a battery of cellular tests providing different genetic end points and biotransformation capabilities. The tests included the following: rat hepatocyte primary culture/DNA repair assay, Salmonella typhimurium histidine locus reversion assa...

journal_title：Cell biology and toxicology

authors： Tong CC,McQueen CA,Brat SV,Williams GM

更新日期：1988-06-01 00:00:00

abstract：:The cytogenetic and hepatotoxic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on mouse liver cells were investigated. Male C57BL/6J strain mice, which have TCDD receptors, were given single intraperitoneal injections of 25, 37.5, 75 and 150 micrograms of TCDD/kg body weight or corn oil carrier alone. Two-third...

journal_title：Cell biology and toxicology

authors： Brooks AL,Jordan SW,Bose KK,Smith J,Allison DC

更新日期：1988-03-01 00:00:00

abstract：:Deoxynivalenol (DON), nivalenol (NIV), T-2 toxin (T2), fumonisin B1 (FB1), zearalenone (ZEA), and moniliformin (MON) mycotoxins are common food and feed contaminants produced by Fusarium spp. However, while they are usually found to co-occur in a large range of commodities, only few data are available on mycotoxin co-...

journal_title：Cell biology and toxicology

authors： Smith MC,Madec S,Troadec S,Coton E,Hymery N

更新日期：2018-06-01 00:00:00

abstract：:Autophagy is a conserved lysosomal degradation process, and abnormal autophagy has been associated with various pathological processes, e.g., neurodegeneration, cancer, and pathogen infection. Small chemical modulators of autophagy show the potential to treat autophagy-associated diseases. Diterpenoids, nature product...

journal_title：Cell biology and toxicology

authors： Huang L,Fu Q,Dai JM,Yan BC,Wang D,Puno PT,Yue J

更新日期：2021-01-23 00:00:00