Abstract:
:In a comprehensive assessment of genotoxicity, sodium fluoride was evaluated in a battery of cellular tests providing different genetic end points and biotransformation capabilities. The tests included the following: rat hepatocyte primary culture/DNA repair assay, Salmonella typhimurium histidine locus reversion assay, adult rat liver epithelial cell/hypoxanthine guanine phosphoribosyl transferase mutation assay, and sister chromatid exchange in two target cell types, human peripheral blood lymphocytes and Chinese hamster ovary cells. Negative findings were made in all assays, indicating that sodium fluoride is not genotoxic in these assays.
journal_name
Cell Biol Toxicoljournal_title
Cell biology and toxicologyauthors
Tong CC,McQueen CA,Brat SV,Williams GMdoi
10.1007/BF00119244subject
Has Abstractpub_date
1988-06-01 00:00:00pages
173-86issue
2eissn
0742-2091issn
1573-6822journal_volume
4pub_type
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