Abstract:
:Various in vitro preparations have been utilized to study the cellular activity of vasoactive agents on renal cortical microvessels and on mesangial cells. The receptors and the transduction pathways of bradykinin and atrial natriuretic factor were characterized on cultured cortical vascular smooth muscle cells from the rabbit kidney. A preparation of afferent arterioles that had been freshly isolated from the rat kidney was used to study the NO-dependent regulation of renin release. The influence of endothelin and angiotensin II on mesangial cell proliferation was evaluated, using cocultures of human endothelial and mesangial cells. These appropriate in vitro preparations have provided new insights on renal vascular endocrinology. However, extrapolation of in vitro data to in vivo physiology must be cautious because the phenotype of vascular cells often changes in culture conditions.
journal_name
Cell Biol Toxicoljournal_title
Cell biology and toxicologyauthors
Essig M,Ledoux S,Tharaux PL,Chatziantoniou C,Dussaule JCdoi
10.1007/BF00438157subject
Has Abstractpub_date
1996-12-01 00:00:00pages
271-4issue
4-6eissn
0742-2091issn
1573-6822journal_volume
12pub_type
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