Glutathione S-transferase P influences the Nrf2-dependent response of cellular thiols to seleno-compounds.

abstract：:Because of a possible role of astrocytes in trialkyltin-induced neurotoxicity in vivo various studies have been performed using cultures of astrocytes or glioma cells in vitro. With respect to cytotoxic potencies of trialkyltins these studies gave rather divergent results. Therefore the aim of the present study was to...

journal_title：Cell biology and toxicology

authors： Seibert H,Mörchel S,Gülden M

更新日期：2004-09-01 00:00:00

abstract：:The effects of the oxidizing agent t-butylhydroperoxide (t-BHP) were investigated on three human cell lines of different origin and growth features (A431 epithelial cells, ADF astrocytoma cells and U937 leukemic cells) using electron microscopy and electron paramagnetic resonance spectroscopy. The results indicate tha...

journal_title：Cell biology and toxicology

authors： Malorni W,Rainaldi G,Rivabene R,Santini MT

更新日期：1994-08-01 00:00:00

abstract：:Lung cancer is one of the most common malignancies worldwide. Actinidia chinensis Planch root extract (acRoots) was found to have the capacity of the anti-tumor, although the molecular mechanisms remain unclear. The present study aims to investigate the molecular mechanisms by which lung cancer cells sense to inhibito...

journal_title：Cell biology and toxicology

authors： Lv J,Wang L,Shen H,Wang X

更新日期：2018-06-01 00:00:00

abstract：:During the last decade, the unbound glutathione content of cultured adherent cells has become a very important biological marker for many pharmacological and toxicological in vitro studies with regard to the protective role of the tripeptide in its reduced form (GSH). However, the literature does not provide extensive...

journal_title：Cell biology and toxicology

authors： Thioudellet C,Oster T,Leroy P,Nicolas A,Wellman M

更新日期：1995-04-01 00:00:00

abstract：:Quinones are widely distributed in the environment, both as natural products and as pollutants. This paper reports that one of the simplest quinones, 2-methyl-1,4-naphthoquinone (menadione), effectively inhibited apoptosis in the presence of UVA. Menadione suppressed the apoptosis induced by serum depletion and cell d...

journal_title：Cell biology and toxicology

authors： Ibuki Y,Toyooka T,Goto R

更新日期：2006-09-01 00:00:00

abstract：:Magnesium, an essential metal that is important in the normal functioning of DNA, has been shown to interact with some of the toxic heavy metals in respect to biochemical and molecular mechanisms and in altering the tumorigenic process. This study examined the influence of magnesium in combination with nickel and cadm...

journal_title：Cell biology and toxicology

authors： Littlefield NA,Hass BS,James SJ,Poirier LA

更新日期：1994-04-01 00:00:00

abstract：:Aldehyde dehydrogenase was measured in primary cultures of hepatocytes obtained with a two-step collagenase perfusion either from human hepatic tissue or from livers of Fisher rats. Basal enzyme activity declines gradually as a function of time in culture, but remains at all times higher when measured with propionalde...

journal_title：Cell biology and toxicology

authors： Marselos M,Strom SC,Michalopoulos G

更新日期：1986-06-01 00:00:00

abstract：BACKGROUND:Heat shock proteins (HSP) are induced during cellular stress. Their role is to chaperone cellular proteins giving protection from denaturation and ultimately preventing cell death. Monocytes are key cells involved in atherosclerosis and are highly responsive to HSP induction. Therefore, we wished to examine ...

journal_title：Cell biology and toxicology

authors： Madden J,Coward JC,Shearman CP,Grimble RF,Calder PC

更新日期：2010-06-01 00:00:00

abstract：:A method for the primary culture of rat liver cells on collagen-coated dextran microcarriers is described. Ethoxycoumarin deethylase (EOD) activity 24 hr after inoculation was comparable for liver cells cultured on microcarriers and on collagen-coated dishes. Cells were cultured on microcarriers for up to 48 hr and re...

journal_title：Cell biology and toxicology

authors： Voss JU,Seibert H

更新日期：1991-10-01 00:00:00

abstract：:The effectiveness of some chelating agents to mobilize cadmium from Chinese hamster ovary cells after chronic exposure (20 hr), as well as from cytosolic metallothionein, was studied. In the first protocol, the most effective substance was 2,3-dimercaptopropanol, followed by 2,3-dimercaptopropane-1-sulfonate and 2,3-d...

journal_title：Cell biology and toxicology

authors： Rau W,Planas-Bohne F,Taylor DM

更新日期：1989-01-01 00:00:00

abstract：:Cd2+ provokes inositol trisphosphate production and releases stored Ca2+, apparently by binding to a zinc site in the external domain of an orphan receptor. One microM Cd2+ evokes an immediate spike in cytosolic free Ca2+, which is similar to that evoked by bradykinin. Platelet-derived growth factor (PDGF) also increa...

journal_title：Cell biology and toxicology

authors： Lyu RM,Smith JB

更新日期：1993-04-01 00:00:00

abstract：:We compared the effects of four quaternary benzo[c]phenanthridine alkaloids--chelerythrine, chelilutine, sanguinarine, and sanguilutine--and two quaternary protoberberine alkaloids-berberine and coptisine--on the human cell line HeLa (cervix carcinoma cells) and the yeasts Saccharomyces cerevisiae and Schizosaccharomy...

journal_title：Cell biology and toxicology

authors： Slaninová I,Táborská E,Bochoráková H,Slanina J

更新日期：2001-01-01 00:00:00

abstract：BACKGROUND AND AIMS:Endoplasmic reticulum (ER) stress is a growing concern for drug-induced toxicity which causes several side effects. Ritonavir, a potent HIV protease inhibitor, induces both ER and mitochondrial stress; however, the missing link between ER stress and mitochondrial damage has been unknown. In the pres...

journal_title：Cell biology and toxicology

authors： Ganta KK,Chaubey B

更新日期：2019-06-01 00:00:00

abstract：:Reciprocal interactions between tumor cells and endothelial cells constitute the most important stage of tumor metastasis. There is growing evidence suggesting that beta-estradiol and vitamin D modulate the progression of steroid-sensitive breast cancers. In keeping with those results, the purpose of the study reporte...

journal_title：Cell biology and toxicology

authors： Paduch R,Kandefer-Szerszeń M

更新日期：2005-09-01 00:00:00

abstract：:In order to assess cigarette smoke-induced oxidative damage to intact cells, an assay was developed to measure cell detachment and protection. Due to the complex nature of cigarette smoke, which contains molecules that can interfere with conventional spectrophotometric and fluorometric biochemical assays, transformed ...

journal_title：Cell biology and toxicology

authors： Pelle E,Ingrassia M,Mammone T,Marenus K,Maes D

更新日期：1998-08-01 00:00:00

abstract：:Adverse effect of nanoparticles may include impairment of phagocyte function. To identify the effect of nanoparticle size on uptake, cytotoxicity, chemotaxis, cytokine secretion, phagocytosis, oxidative burst, nitric oxide production and myeloperoxidase release, leukocytes isolated from human peripheral blood, monocyt...

journal_title：Cell biology and toxicology

authors： Prietl B,Meindl C,Roblegg E,Pieber TR,Lanzer G,Fröhlich E

更新日期：2014-02-01 00:00:00

abstract：:In vitro directional migration of 10T1/2 fibroblasts is partially inhibited by TPA but not by its non-promoting analogues. Other tumor promoters, e.g., phenobarbital, saccharin, and benzoylperoxide had no measurable effect when added in concentrations known to affect in vitro two-step transformation or intercellular c...

journal_title：Cell biology and toxicology

authors： Verschueren H

更新日期：1985-06-01 00:00:00

abstract：:The development of nontoxic but effective radioprotectors is needed because of the increasing risk of human exposure to ionizing radiation. We have reported that alpha-lipoic acid confers considerable radio-protective effect in mouse tissues when given prior to x-irradiation. In the present study, alpha-lipoic acid su...

journal_title：Cell biology and toxicology

authors： Manda K,Ueno M,Moritake T,Anzai K

更新日期：2007-03-01 00:00:00

abstract：:We assessed the in vitro toxicity of various particles on three murine macrophage cell lines, (J774A.1, WR19M.1, RAW264.7). The cells were exposed to aqueous suspensions (0-100 microg/30 mm2 well) of urban particulate matter (SRM-1648, SRM-1649, EHC-93), fine particulate matter (PM2.5), titanium dioxide (SRM-154b), an...

journal_title：Cell biology and toxicology

authors： Chauhan V,Breznan D,Goegan P,Nadeau D,Karthikeyan S,Brook JR,Vincent R

更新日期：2004-07-01 00:00:00

abstract：:Various in vitro preparations have been utilized to study the cellular activity of vasoactive agents on renal cortical microvessels and on mesangial cells. The receptors and the transduction pathways of bradykinin and atrial natriuretic factor were characterized on cultured cortical vascular smooth muscle cells from t...

journal_title：Cell biology and toxicology

authors： Essig M,Ledoux S,Tharaux PL,Chatziantoniou C,Dussaule JC

更新日期：1996-12-01 00:00:00

abstract：:The article Is the clinical lipidomics a potential goldmine?, written by Linlin Zhang, Xianlin Han and Xiangdong Wang, was originally published electronically on the publisher's internet portal (currently SpringerLink) on 21 July 2018 with open access. With the author(s)' decision to step. ...

journal_title：Cell biology and toxicology

authors： Zhang L,Han X,Wang X

更新日期：2020-06-01 00:00:00

abstract：:Recent studies have demonstrated that the insecticide DDT is a tumor promoting agent. Similar to many other tumor promoting agents, DDT has been shown to inhibit gap junctional intercellular communication (GJIC) between cells in culture, and it has been suggested that DDT-induced loss of communication between adjacent...

journal_title：Cell biology and toxicology

authors： Fransson R,Nicotera P,Wärngård L,Ahlborg UG

更新日期：1990-04-01 00:00:00

abstract：:Exposure to compounds with cancer-potentiating effects can contribute to the progression of cancer. Herein we have discovered for the first time that benzophenone-3 (BP-3), a chemical used as sunscreen in various cosmetic products, enhances the ability of lung cancer cells to undergo metastasis. The exposure of the lu...

journal_title：Cell biology and toxicology

authors： Phiboonchaiyanan PP,Busaranon K,Ninsontia C,Chanvorachote P

更新日期：2017-06-01 00:00:00

abstract：:In order to clarify the protective mechanism of sodium molybdate against the acute toxicity of cadmium chloride in rat, the effect of in vivo sodium molybdate pretreatment on the cytotoxic action of cadmium in isolated hepatocytes was studied. The cytosolic pH of hepatocytes isolated from untreated rats immediately de...

journal_title：Cell biology and toxicology

authors： Koizumi T,Yokota T,Fukuchi M,Tatsumoto H,Yamane Y

更新日期：1991-10-01 00:00:00

abstract：:Generating large amounts of recombinant protein in transgenic animals is often challenging and has a number of drawbacks compared to cell culture systems. The baculovirus expression vector system (BEVS) uses virus-infected insect cells to produce recombinant proteins to high levels, and these are usually processed in ...

journal_title：Cell biology and toxicology

authors： Hitchman RB,Possee RD,Crombie AT,Chambers A,Ho K,Siaterli E,Lissina O,Sternard H,Novy R,Loomis K,Bird LE,Owens RJ,King LA

更新日期：2010-02-01 00:00:00

abstract：:The mouse skin cocarcinogens fluoranthene, pyrene, and undecane were used with the indirect-acting carcinogen, benzo(a)pyrene (BP), and the direct-acting alkylating carcinogen, beta-propiolactone (BPL), in an in vitro transformation assay. Dose response, cytotoxicity, and transformation studies with these compounds we...

journal_title：Cell biology and toxicology

authors： Atchison M,Atchison ML,Van Duuren BL

更新日期：1985-10-01 00:00:00

abstract：:An in vitro human nasal model was developed as a tool to study the local tolerability of nasal powder forms using excised nasal mucosa in a diffusion chamber. The suitability of this model was tested using Sandostatin (SMS) an octapeptide analog of somatostatin, as a reference drug enhanced by Avicel (microcrystalline...

journal_title：Cell biology and toxicology

authors： de Fraissinette A,Kolopp M,Schiller I,Fricker G,Gammert C,Pospischil A,Vonderscher J,Richter F

更新日期：1995-10-01 00:00:00

abstract：:The culture of rabbit tenocytes could be a useful model in the study of the physiopathology and pharmacotoxicology of tendons. This work was undertaken to examine the in vitro behavior of tenocytes form juvenile rabbit Achilles tendons. We report observations of the morphological and biological characteristics of prim...

journal_title：Cell biology and toxicology

authors： Bernard-Beaubois K,Hecquet C,Houcine O,Hayem G,Adolphe M

更新日期：1997-02-01 00:00:00

abstract：:A tissue system in which fibroblasts and myocytes from chick embryonic hearts were separately maintained was used to study the toxicity of ethanol. To reproduce the teratogenic effects of acute, high concentrations of ethanol typical of "binge" drinking, an open tissue culture system was employed. With open cultures, ...

journal_title：Cell biology and toxicology

authors： Ni Y,Feng-Chen KC,Hsu L

更新日期：1992-01-01 00:00:00

abstract：:Harmful algal blooms (HABs) can have both lethal and sublethal impacts on shellfish. To understand the possible roles of haemocytes in bivalve immune responses to HABs and how the algae are affected by these cells (haemocytes), in vitro tests between cultured harmful algal species and haemocytes of the northern quahog...

journal_title：Cell biology and toxicology

authors： Hégaret H,da Silva PM,Wikfors GH,Haberkorn H,Shumway SE,Soudant P

更新日期：2011-08-01 00:00:00