Silver nanoparticles and silver ions cause inflammatory response through induction of cell necrosis and the release of mitochondria in vivo and in vitro.

abstract：:Galectin 3 (Gal-3) is upregulated in gastric epithelial cells as a host response to Helicobacter pylori infection. However, the significance of Gal-3 expression in H. pylori-infected cells is not well established. We analyzed Gal-3 intracellular expression, localization, and its effects in H. pylori-infected gastric e...

journal_title：Cell biology and toxicology

authors： Subhash VV,Ho B

更新日期：2016-02-01 00:00:00

abstract：:The effects of the oxidizing agent t-butylhydroperoxide (t-BHP) were investigated on three human cell lines of different origin and growth features (A431 epithelial cells, ADF astrocytoma cells and U937 leukemic cells) using electron microscopy and electron paramagnetic resonance spectroscopy. The results indicate tha...

journal_title：Cell biology and toxicology

authors： Malorni W,Rainaldi G,Rivabene R,Santini MT

更新日期：1994-08-01 00:00:00

abstract：:The effect of noncytotoxic doses of argemone oil (AO) and butter yellow (BY), the common adulterants in edible oil, on free radical generation and signaling pathway for cell proliferation in primary cells of gall bladder (GB) was undertaken. AO and BY showed no cytotoxicity at 0.1 μl/ml and 0.1 μg/ml concentration, re...

journal_title：Cell biology and toxicology

authors： Mishra V,Ansari KM,Khanna R,Das M

更新日期：2012-06-01 00:00:00

abstract：:An in vitro human nasal model was developed as a tool to study the local tolerability of nasal powder forms using excised nasal mucosa in a diffusion chamber. The suitability of this model was tested using Sandostatin (SMS) an octapeptide analog of somatostatin, as a reference drug enhanced by Avicel (microcrystalline...

journal_title：Cell biology and toxicology

authors： de Fraissinette A,Kolopp M,Schiller I,Fricker G,Gammert C,Pospischil A,Vonderscher J,Richter F

更新日期：1995-10-01 00:00:00

abstract：:A method for the primary culture of rat liver cells on collagen-coated dextran microcarriers is described. Ethoxycoumarin deethylase (EOD) activity 24 hr after inoculation was comparable for liver cells cultured on microcarriers and on collagen-coated dishes. Cells were cultured on microcarriers for up to 48 hr and re...

journal_title：Cell biology and toxicology

authors： Voss JU,Seibert H

更新日期：1991-10-01 00:00:00

abstract：:Cyclosporin A induces in vivo a severe nephrotoxicity characterized by a large decrease in renal hemodynamics. The aim of this study is to establish the ability of the known NO donor 3-morpholinosydnonimine (SIN-1) to prevent the cyclosporin A-induced contraction by using rat isolated glomeruli and cultured glomerular...

journal_title：Cell biology and toxicology

authors： Potier M,Winicki J,Cambar J

更新日期：1996-12-01 00:00:00

abstract：:The purpose of the study was to determine whether along and in combination melatonin (MLT) and pentoxifylline (PTX) exerted beneficial effects on histopathological changes and changes in oxidant and antioxidant systems in liver caused by CCl4-induced liver toxicity in mice. Mice were randomly divided into six groups: ...

journal_title：Cell biology and toxicology

authors： Noyan T,Kömüroğlu U,Bayram I,Sekeroğlu MR

更新日期：2006-11-01 00:00:00

abstract：:We explored if epigenetic mechanisms could be involved in the down-regulated expression of catalase gene (CAT) in the doxorubicin-resistant acute myelogenous leukemia (AML)-2/DX100 cells. Down-regulated CAT expression in AML-2/DX100 cells was completely recovered after treatment of hydrogen peroxide (H(2)O(2)) and his...

journal_title：Cell biology and toxicology

authors： Lee TB,Moon YS,Choi CH

更新日期：2012-02-01 00:00:00

abstract：:Ten compounds representative of diverse classes of chemicals were evaluated for their cytotoxicity and transforming ability to human skin fibroblasts in vitro. Only five of the ten compounds were highly cytotoxic in the 0-100 micrograms/ml range and their order of cytotoxicity was: 2,5-bis(1-aziridinyl)-3,6-bis(carboe...

journal_title：Cell biology and toxicology

authors： Kurian P,Nesnow S,Milo GE

更新日期：1990-04-01 00:00:00

abstract：:In pharmaceutical research, in vitro toxicity tests, for assessing the potential toxicity of new chemical entities are necessary in the early stages of the developmental process, when no information is available about the metabolism or even the target organ toxicity of the compounds to be tested. In vitro specific org...

journal_title：Cell biology and toxicology

authors： Negro GD,Bonato M,Gribaldo L

更新日期：2001-01-01 00:00:00

abstract：BACKGROUND:Heat shock proteins (HSP) are induced during cellular stress. Their role is to chaperone cellular proteins giving protection from denaturation and ultimately preventing cell death. Monocytes are key cells involved in atherosclerosis and are highly responsive to HSP induction. Therefore, we wished to examine ...

journal_title：Cell biology and toxicology

authors： Madden J,Coward JC,Shearman CP,Grimble RF,Calder PC

更新日期：2010-06-01 00:00:00

abstract：:A useful approach for constructing dose-response relationships and for studying the underlying mechanisms by which a xenobiotic agent enhances airway reactivity is to measure the response of an isolated airway following ex vivo exposure to a pollutant. We have in this way determined the dose-response relationship betw...

journal_title：Cell biology and toxicology

authors： Roux E,Ouedraogo N,Hyvelin JM,Savineau JP,Marthan R

更新日期：2002-01-01 00:00:00

abstract：:The polyether toxin, okadaic acid, causes diarrhetic shellfish poisoning in humans. Despite extensive research into its cellular targets using rodent models, we know little about its putative effect(s) on innate immunity. We inoculated larvae of the greater wax moth, Galleria mellonella, with physiologically relevant ...

journal_title：Cell biology and toxicology

authors： Coates CJ,Lim J,Harman K,Rowley AF,Griffiths DJ,Emery H,Layton W

更新日期：2019-06-01 00:00:00

abstract：:New developments in mutagenic risk assessment have appeared in the past few years. New methods have been developed such as in vitro micronucleus assay for chromosomal alterations, comet assay for primary DNA damage, use of transgenic animals to detect in vivo gene mutations, and fluorescent in situ hybridization metho...

journal_title：Cell biology and toxicology

authors： Marzin D

更新日期：1999-01-01 00:00:00

abstract：:The risk presented by mycotoxins is a toxicological problem. As the data given by physico-chemical analysis may be difficult to translate in terms of toxicity, however, especially when considering multiple contamination, we have developed a system for toxicological analysis of mycotoxins using cell cultures of differe...

journal_title：Cell biology and toxicology

authors： Robbana-Barnat S,Lafarge-Frayssinet C,Frayssinet C

更新日期：1989-06-01 00:00:00

abstract：:The mutation rates of tumor suppressor protein p53 gene (TP53) are high in lung adenocarcinoma and promote the development of acquired drug resistance. The present study evaluated the p53-dependent role in lung cancer cell sensitivity to PI3K-specific inhibitors, PI3K-associated inhibitors, PI3K-non-related inhibitors...

journal_title：Cell biology and toxicology

authors： Hou J,Cao X,Cheng Y,Wang X

更新日期：2020-10-01 00:00:00

abstract：:Sea urchin embryos and larvae represent suitable model systems on where to investigate the effects of heavy metals on development and cell viability. Here, we tested the toxic effects of low (10(-12 )M), medium (10(-9 )M), and high (10(-6 )M) cadmium chloride concentrations, mimicking unpolluted, moderately and highly...

journal_title：Cell biology and toxicology

authors： Filosto S,Roccheri MC,Bonaventura R,Matranga V

更新日期：2008-12-01 00:00:00

abstract：:We have previously synthesized various diazenecarboxamides (subsequently referred to as diazenes) that were cytotoxic to several tumor cell lines. To increase their biological activity, the structure has been modified appropriately. In the present study we examined the effects of N(1)-phenyl-N(2)-(2-pyridinylmethyl)di...

journal_title：Cell biology and toxicology

authors： Jakopec S,Dubravcic K,Brozovic A,Polanc S,Osmak M

更新日期：2006-01-01 00:00:00

abstract：:Although estrogens have been detected in some echinoderm species, their role is not clearly understood; so we examined the effects of estrogens administered to sea urchin embryos and larvae. A typical malformation was exogastrulation, induced by the exposure to ethynylestradiol (EER) in a defined period of 12 h from 1...

journal_title：Cell biology and toxicology

authors： Kiyomoto M,Kikuchi A,Morinaga S,Unuma T,Yokota Y

更新日期：2008-12-01 00:00:00

abstract：:The study investigates the effect of fenugreek seed polyphenol extract (FPEt) on ethanol-induced damage in rat liver. Chronic ethanol administration (6 g kg(-1) day(-1) x 60 days) caused liver damage that was manifested by excessive formation of thiobarbituric-acid-reactive substances, lipid hydroperoxides, and conjug...

journal_title：Cell biology and toxicology

authors： Kaviarasan S,Sundarapandiyan R,Anuradha CV

更新日期：2008-10-01 00:00:00

abstract：:Chrysotile is the predominant type of asbestos used in the United States and thus represents the most important source of exposure to asbestos already in place. While the steepest exposure-response observed for lung cancer has been in workers exposed to chrysotile in textile operations, some argue that chrysotile is l...

journal_title：Cell biology and toxicology

authors： Dement JM

更新日期：1991-01-01 00:00:00

abstract：:This study was implemented to test the Episkin model of reconstructed epidermis in the evaluation of the efficacy of cosmetic or dermopharmaceutical products on cutaneous energy metabolism. The energy metabolism is evaluated by measuring the concentration of intracellular ATP by a method using an ultrasensitive biolum...

journal_title：Cell biology and toxicology

authors： Buche P,Violin L,Girard P

更新日期：1994-12-01 00:00:00

abstract：:The culture of rabbit tenocytes could be a useful model in the study of the physiopathology and pharmacotoxicology of tendons. This work was undertaken to examine the in vitro behavior of tenocytes form juvenile rabbit Achilles tendons. We report observations of the morphological and biological characteristics of prim...

journal_title：Cell biology and toxicology

authors： Bernard-Beaubois K,Hecquet C,Houcine O,Hayem G,Adolphe M

更新日期：1997-02-01 00:00:00

abstract：:Sensitivity of baker's yeast to disulfiram (DSF) and hypersensitivity of a mutant devoid of Cu, Zn-superoxide dismutase to this compound is reported, demonstrating that yeast may be a simple convenient eukaryotic model to study the mechanism of DSF toxicity. DSF was found to induce oxidative stress in yeast cells demo...

journal_title：Cell biology and toxicology

authors： Kwolek-Mirek M,Zadrag-Tecza R,Bartosz G

更新日期：2012-02-01 00:00:00

abstract：:Cellular accumulation of mono(2-ethylhexyl)phthalate (MEHP) has been recently demonstrated to disturb fat cell energy metabolism; however, the underlying mechanism remained unclear. The study aimed to determine how MEHP influenced fat cell transcriptome and how the changes might contribute to bioenergetics. Because of...

journal_title：Cell biology and toxicology

authors： Chiang HC,Wang CH,Yeh SC,Lin YH,Kuo YT,Liao CW,Tsai FY,Lin WY,Chuang WH,Tsou TC

更新日期：2017-12-01 00:00:00

abstract：:Microfilaments and microtubules are components of the cytoskeleton which could be implicated in neoplastic transformation. We studied the effect of two hepatic tumor promoters, phenobarbital (PB) and biliverdin (BV), on microfilaments and microtubules of non-transformed (Cl3) and transformed (FV) hepatic epithelial ce...

journal_title：Cell biology and toxicology

authors： Decloitre F,Lafarge-Frayssinet C,Martin M,Frayssinet C

更新日期：1990-01-01 00:00:00

abstract：:Many of the differentiated functions of hepatocytes are lost in culture, yet addition of certain medium supplements can aid in the retention of differentiated character. Therefore, the effect of time in monolayer culture on rat hepatocyte glutathione (GSH) synthesis and sensitivity to the GSH detoxicated xenobiotic et...

journal_title：Cell biology and toxicology

authors： Meredith MJ

更新日期：1986-12-01 00:00:00

abstract：:In order to assess cigarette smoke-induced oxidative damage to intact cells, an assay was developed to measure cell detachment and protection. Due to the complex nature of cigarette smoke, which contains molecules that can interfere with conventional spectrophotometric and fluorometric biochemical assays, transformed ...

journal_title：Cell biology and toxicology

authors： Pelle E,Ingrassia M,Mammone T,Marenus K,Maes D

更新日期：1998-08-01 00:00:00

abstract：:Considering the recent studies that question previously reported cardio-protective effects of estrogen, there is a growing concern that endocrine disruptors may also contribute to the pathology of cardiovascular disease. PCB153 is one of the most commonly found polychlorinated biphenyls, and based on epidemiological s...

journal_title：Cell biology and toxicology

authors： Felty Q

更新日期：2011-02-01 00:00:00

abstract：:Ziram, a zinc dithiocarbamate is widely used worldwide as a fungicide in agriculture. In order to investigate ziram-induced changes in macrophage functions and polarization, human monocytes-derived macrophages in culture were treated with ziram at 0.01-10 μmol.L-1 for 4-24 h. To characterize zinc involvement in these ...

journal_title：Cell biology and toxicology

authors： Parny M,Bernad J,Prat M,Salon M,Aubouy A,Bonnafé E,Coste A,Pipy B,Treilhou M

更新日期：2020-07-25 00:00:00