Modifications of microfilaments and microtubules induced by two hepatic tumor promoters, phenobarbital and biliverdin in non-transformed and transformed hepatic cell lines.

abstract：:Owing to the excellent antibacterial and antiviral activity, silver nanoparticles have a widespread use in the food and pharmaceutical industries. With the increase in the production and use of the related products, the potential hazard of silver nanoparticles has aroused public attention. The main purpose of this stu...

journal_title：Cell biology and toxicology

authors： Li L,Bi Z,Hu Y,Sun L,Song Y,Chen S,Mo F,Yang J,Wei Y,Wei X

更新日期：2020-05-04 00:00:00

abstract：BACKGROUND AND AIMS:Endoplasmic reticulum (ER) stress is a growing concern for drug-induced toxicity which causes several side effects. Ritonavir, a potent HIV protease inhibitor, induces both ER and mitochondrial stress; however, the missing link between ER stress and mitochondrial damage has been unknown. In the pres...

journal_title：Cell biology and toxicology

authors： Ganta KK,Chaubey B

更新日期：2019-06-01 00:00:00

abstract：:Aldehyde dehydrogenase was measured in primary cultures of hepatocytes obtained with a two-step collagenase perfusion either from human hepatic tissue or from livers of Fisher rats. Basal enzyme activity declines gradually as a function of time in culture, but remains at all times higher when measured with propionalde...

journal_title：Cell biology and toxicology

authors： Marselos M,Strom SC,Michalopoulos G

更新日期：1986-06-01 00:00:00

abstract：:The study investigates the effect of fenugreek seed polyphenol extract (FPEt) on ethanol-induced damage in rat liver. Chronic ethanol administration (6 g kg(-1) day(-1) x 60 days) caused liver damage that was manifested by excessive formation of thiobarbituric-acid-reactive substances, lipid hydroperoxides, and conjug...

journal_title：Cell biology and toxicology

authors： Kaviarasan S,Sundarapandiyan R,Anuradha CV

更新日期：2008-10-01 00:00:00

abstract：:Various in vitro preparations have been utilized to study the cellular activity of vasoactive agents on renal cortical microvessels and on mesangial cells. The receptors and the transduction pathways of bradykinin and atrial natriuretic factor were characterized on cultured cortical vascular smooth muscle cells from t...

journal_title：Cell biology and toxicology

authors： Essig M,Ledoux S,Tharaux PL,Chatziantoniou C,Dussaule JC

更新日期：1996-12-01 00:00:00

abstract：:Chrysotile is the predominant type of asbestos used in the United States and thus represents the most important source of exposure to asbestos already in place. While the steepest exposure-response observed for lung cancer has been in workers exposed to chrysotile in textile operations, some argue that chrysotile is l...

journal_title：Cell biology and toxicology

authors： Dement JM

更新日期：1991-01-01 00:00:00

abstract：:Pulmonary alveolar macrophages exposed to very short chrysotile asbestos fibers present a typical cytotoxic response: extracellular releases of lactate dehydrogenase and beta-galactosidase, and a decrease in cellular ATP content. The objective of this study was to determine if nicotinamide and 3-aminobenzamide, two in...

journal_title：Cell biology and toxicology

authors： Nadeau D,Lane DA

更新日期：1988-03-01 00:00:00

abstract：:The goal of cancer eradication has been overshadowed despite the continuous improvement in research and generation of novel cancer therapeutic drugs. One of the undeniable existing problems is drug resistance due to which the paradigm of killing all cancer cells is ineffective. Tumor microenvironment plays a crucial r...

journal_title：Cell biology and toxicology

authors： Kadel D,Zhang Y,Sun HR,Zhao Y,Dong QZ,Qin LX

更新日期：2019-10-01 00:00:00

abstract：:In order to assess cigarette smoke-induced oxidative damage to intact cells, an assay was developed to measure cell detachment and protection. Due to the complex nature of cigarette smoke, which contains molecules that can interfere with conventional spectrophotometric and fluorometric biochemical assays, transformed ...

journal_title：Cell biology and toxicology

authors： Pelle E,Ingrassia M,Mammone T,Marenus K,Maes D

更新日期：1998-08-01 00:00:00

abstract：:Sensitivity of baker's yeast to disulfiram (DSF) and hypersensitivity of a mutant devoid of Cu, Zn-superoxide dismutase to this compound is reported, demonstrating that yeast may be a simple convenient eukaryotic model to study the mechanism of DSF toxicity. DSF was found to induce oxidative stress in yeast cells demo...

journal_title：Cell biology and toxicology

authors： Kwolek-Mirek M,Zadrag-Tecza R,Bartosz G

更新日期：2012-02-01 00:00:00

abstract：:Asiatic acid (AA), a triterpene, is known to be cytotoxic to several tumor cell lines. AA induces dose- and time-dependent cell death in U-87 MG human glioblastoma. This cell death occurs via both apoptosis and necrosis. The effect of AA may be cell type-specific as AA-induced cell death was mainly apoptotic in colon ...

journal_title：Cell biology and toxicology

authors： Cho CW,Choi DS,Cardone MH,Kim CW,Sinskey AJ,Rha C

更新日期：2006-11-01 00:00:00

abstract：:The histopathological response and cell culture characteristics of liver cells from the R16 (grc-) strain of rats, which carries an MHC-linked deletion, were examined one week after a single intraperitoneal injection of 200 mg/kg body weight diethylnitrosamine (DEN) and were compared with the response of liver cells f...

journal_title：Cell biology and toxicology

authors： Smith GJ,Kunz HW,Dunsford HA,Gill TJ 3rd

更新日期：1990-04-01 00:00:00

abstract：:The mutation rates of tumor suppressor protein p53 gene (TP53) are high in lung adenocarcinoma and promote the development of acquired drug resistance. The present study evaluated the p53-dependent role in lung cancer cell sensitivity to PI3K-specific inhibitors, PI3K-associated inhibitors, PI3K-non-related inhibitors...

journal_title：Cell biology and toxicology

authors： Hou J,Cao X,Cheng Y,Wang X

更新日期：2020-10-01 00:00:00

abstract：:Sister chromatid exchange rate was studied in 12 early diagnosed cases of nasopharyngeal carcinoma and in their paired controls. Exchange frequencies were also analyzed in 100 healthy subjects distributed in four regions of Hunan Province and correlated to nationality, age and sex. The incidence of sister chromatid ex...

journal_title：Cell biology and toxicology

authors： Hu YC,Li GY,Peng L,Deng YM

更新日期：1987-09-01 00:00:00

abstract：:Transforming growth factor-beta1 (TGF-beta1) can activate mitogen-activated protein kinases (MAPKs) in many types of cells. The mechanism of this activation is not well elucidated. Here, we explore the role of TGF-beta/Smads signaling compounds in TGF-beta1-mediated activation of extracellular signal-regulated kinase ...

journal_title：Cell biology and toxicology

authors： Huo YY,Hu YC,He XR,Wang Y,Song BQ,Zhou PK,Zhu MX,Li G,Wu DC

更新日期：2007-03-01 00:00:00

abstract：:Autophagy is a conserved lysosomal degradation process, and abnormal autophagy has been associated with various pathological processes, e.g., neurodegeneration, cancer, and pathogen infection. Small chemical modulators of autophagy show the potential to treat autophagy-associated diseases. Diterpenoids, nature product...

journal_title：Cell biology and toxicology

authors： Huang L,Fu Q,Dai JM,Yan BC,Wang D,Puno PT,Yue J

更新日期：2021-01-23 00:00:00

abstract：:In the US alone, around 60,000 lives/year are lost to colon cancer. In order to study the mechanisms of colon carcinogenesis, in vitro model systems are required in addition to in vivo models. Towards this end, we have used the HT-29 colon cancer cells, cultured in Dulbecco's Modified Eagle Medium (DMEM), which were e...

journal_title：Cell biology and toxicology

authors： Myers JN,Harris KL,Rekhadevi PV,Pratap S,Ramesh A

更新日期：2021-01-07 00:00:00

abstract：:2,2'-Dichlorodiethyl sulfide (sulfur mustard, HD, 1,1'-thiobis [2-chloroethane]) is a potent vesicant which can cause severe lesions to skin, lung, and eyes. Due to the high number of debilitating exposures during the Iran-Iraq war to the alkylating agent, HD, there is an increased interest in its mechanism of action ...

journal_title：Cell biology and toxicology

authors： Meier HL

更新日期：1996-06-01 00:00:00

abstract：:Knowledge of the acute toxic effects of chemicals is important for the protection of exposed humans. Since sufficient information in humans is often lacking, experiments on laboratory animals must be performed. The LD50 test, which requires large numbers of animals, has become the preferred procedure. It is now widely...

journal_title：Cell biology and toxicology

authors： Zbinden G

更新日期：1986-09-01 00:00:00

abstract：:Health risks associated with the inhalation of potentially toxic materials have been a topic of great public concern. In vitro cellular analyses can provide mechanistic information on the molecular-level responses of lung-derived cell lines to a variety of these hazards. This understanding may be used to develop metho...

journal_title：Cell biology and toxicology

authors： Boesewetter DE,Collier JL,Kim AM,Riley MR

更新日期：2006-03-01 00:00:00

abstract：:Two human hepatoma cell lines, KYN-2 and Mz-Hep-1 were characterized in terms of glucuronidation capacity and inducibility of cytochrome P4501A1/1A2 and several UDP-glucuronosyltransferases (UGTs). Cytochrome P4501A1/1A2 activity was measured using 7-ethoxyresorufin and that of UGTs with 16 different substrates. The e...

journal_title：Cell biology and toxicology

authors： Abid A,Sabolovic N,Magdalou J

更新日期：1996-04-01 00:00:00

abstract：:Cationic lipids are widely used for gene transfer in vitro and show promise as vectors for in vivo gene therapy applications. However, there is limited understanding of the cellular mechanisms involved in nonviral gene transfer. We investigated two major steps that could be limiting barriers to cationic lipid-mediated...

journal_title：Cell biology and toxicology

authors： Escriou V,Ciolina C,Helbling-Leclerc A,Wils P,Scherman D

更新日期：1998-03-01 00:00:00

abstract：:Presently, a large effort is being made worldwide to increase the sustainability of industrial development, while preserving not only the quality of the environment but also that of animal and human life. In this work, sea urchin early developmental stages were used as a model to test the effects of the organophosphat...

journal_title：Cell biology and toxicology

authors： Aluigi MG,Angelini C,Corte G,Falugi C

更新日期：2008-12-01 00:00:00

abstract：:Skin intoxication by bis(beta-chloroethyl)sulfide (BCES; sulfur mustard) induces cutaneous lesions similar to thermal burns, characterized by slowness of skin healing. We have developed an in vitro model of skin equivalent to investigate mechanisms involved in this delay. Direct intoxication of dermal equivalent produ...

journal_title：Cell biology and toxicology

authors： Gentilhomme E,Reano A,Pradel D,Bergier J,Schmitt D,Neveux Y

更新日期：1998-02-01 00:00:00

abstract：:To determine the toxicological effects of complex mixtures of pesticides, we obtained data on 100 pesticide residues in common foods of central Italy. Fifteen pesticides were more regularly detected at higher levels (dithiocarbamates, benomyl/carbendazim, thiabendazole, diphenylamine, chlorthalonil, procymidone, fenar...

journal_title：Cell biology and toxicology

authors： Dolara P,Vezzani A,Caderni G,Coppi C,Torricelli F

更新日期：1993-10-01 00:00:00

abstract：:In pharmaceutical research, in vitro toxicity tests, for assessing the potential toxicity of new chemical entities are necessary in the early stages of the developmental process, when no information is available about the metabolism or even the target organ toxicity of the compounds to be tested. In vitro specific org...

journal_title：Cell biology and toxicology

authors： Negro GD,Bonato M,Gribaldo L

更新日期：2001-01-01 00:00:00

abstract：:Aging, injuries, and diseases can be considered as the result of malfunctioning or damaged cells. Regenerative medicine aims to restore tissue homeostasis by repairing or replacing cells, tissues, or damaged organs, by linking and combining different disciplines including engineering, technology, biology, and medicine...

journal_title：Cell biology and toxicology

authors： Mora C,Serzanti M,Consiglio A,Memo M,Dell'Era P

更新日期：2017-08-01 00:00:00

abstract：:The risk presented by mycotoxins is a toxicological problem. As the data given by physico-chemical analysis may be difficult to translate in terms of toxicity, however, especially when considering multiple contamination, we have developed a system for toxicological analysis of mycotoxins using cell cultures of differe...

journal_title：Cell biology and toxicology

authors： Robbana-Barnat S,Lafarge-Frayssinet C,Frayssinet C

更新日期：1989-06-01 00:00:00

abstract：:Inhibition of endosomal acidification disturbs insulin signaling in both liver and adipose cells. In this study we used MIN6 beta cells to determine whether bafilomycin, a potent inhibitor of the proton-translocating vacuolar ATPase, disrupts insulin signaling in islet beta cells. Pretreatment of MIN6 cells with varyi...

journal_title：Cell biology and toxicology

authors： Hettiarachchi KD,Zimmet PZ,Myers MA

更新日期：2006-05-01 00:00:00

abstract：:Metolachlor, a commonly used herbicide in the Midwestern USA, functions by inhibiting chlorophyll and protein synthesis in target plants. Herbicide exposure has led to detrimental effects in several organisms, affecting their growth and behavior; however, its mechanism of action in nontarget organisms is not yet clear...

journal_title：Cell biology and toxicology

authors： Lowry DM,Greiner D,Fretheim M,Ubben M,Dhanwada KR

更新日期：2013-08-01 00:00:00