Clinical potentials of human pluripotent stem cells.

abstract：:In a number of adverse drug reactions leading to hepatotoxicity drug metabolism is thought to be involved by generation of reactive metabolites from nontoxic drugs. In this study, an in vitro assay was developed for measurement of the impact of metabolic activation of compound on the cytotoxicity toward a human hepati...

journal_title：Cell biology and toxicology

authors： Otto M,Hansen SH,Dalgaard L,Dubois J,Badolo L

更新日期：2008-01-01 00:00:00

abstract：:Owing to the excellent antibacterial and antiviral activity, silver nanoparticles have a widespread use in the food and pharmaceutical industries. With the increase in the production and use of the related products, the potential hazard of silver nanoparticles has aroused public attention. The main purpose of this stu...

journal_title：Cell biology and toxicology

authors： Li L,Bi Z,Hu Y,Sun L,Song Y,Chen S,Mo F,Yang J,Wei Y,Wei X

更新日期：2020-05-04 00:00:00

abstract：:The ubiquitin proteasome-proteolytic pathway has emerged as one of the most significant pathways in modulating protein homeostasis under both normal and disease states. The use of proteasome inhibitors (PI) has played a pivotal role in understanding protein turn over. The main objective of this work was to develop a c...

journal_title：Cell biology and toxicology

authors： Keyomarsi K,Efuet ET,Bui TN

更新日期：2011-04-01 00:00:00

abstract：:To determine the toxicological effects of complex mixtures of pesticides, we obtained data on 100 pesticide residues in common foods of central Italy. Fifteen pesticides were more regularly detected at higher levels (dithiocarbamates, benomyl/carbendazim, thiabendazole, diphenylamine, chlorthalonil, procymidone, fenar...

journal_title：Cell biology and toxicology

authors： Dolara P,Vezzani A,Caderni G,Coppi C,Torricelli F

更新日期：1993-10-01 00:00:00

abstract：:Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) as a serious event has high mortality and medical costs. Systemic inflammation and immune response are the major factors influencing the outcome and quality of patient with AECOPD. On basis of identification and validation of AECOPD-specific inflamma...

journal_title：Cell biology and toxicology

authors： Shi L,Zhu B,Xu M,Wang X

更新日期：2018-04-01 00:00:00

abstract：BACKGROUND:Heat shock proteins (HSP) are induced during cellular stress. Their role is to chaperone cellular proteins giving protection from denaturation and ultimately preventing cell death. Monocytes are key cells involved in atherosclerosis and are highly responsive to HSP induction. Therefore, we wished to examine ...

journal_title：Cell biology and toxicology

authors： Madden J,Coward JC,Shearman CP,Grimble RF,Calder PC

更新日期：2010-06-01 00:00:00

abstract：:A tissue system in which fibroblasts and myocytes from chick embryonic hearts were separately maintained was used to study the toxicity of ethanol. To reproduce the teratogenic effects of acute, high concentrations of ethanol typical of "binge" drinking, an open tissue culture system was employed. With open cultures, ...

journal_title：Cell biology and toxicology

authors： Ni Y,Feng-Chen KC,Hsu L

更新日期：1992-01-01 00:00:00

abstract：:It has been well documented in in vitro studies that ambient airborne particulate matter (PM) with an aerodynamic diameter less than 2.5 μm (PM(2.5)) is capable of inducing oxidative stress, which plays a key role in PM(2.5)-mediated cytotoxicity. Although nuclear factor erythroid-2-related factor 2 (Nrf2) has been sh...

journal_title：Cell biology and toxicology

authors： Deng X,Rui W,Zhang F,Ding W

更新日期：2013-06-01 00:00:00

abstract：:Ten compounds representative of diverse classes of chemicals were evaluated for their cytotoxicity and transforming ability to human skin fibroblasts in vitro. Only five of the ten compounds were highly cytotoxic in the 0-100 micrograms/ml range and their order of cytotoxicity was: 2,5-bis(1-aziridinyl)-3,6-bis(carboe...

journal_title：Cell biology and toxicology

authors： Kurian P,Nesnow S,Milo GE

更新日期：1990-04-01 00:00:00

abstract：:Okadaic acid (OA), produced by dinoflagellates during harmful algal blooms (HAB), belongs to the Diarrheic Shellfish Poisoning toxins that cause gastrointestinal symptoms in humans after consumption. In the present work, Ruditapes decussatus haemocytes were selected to evaluate the effect of OA on cell viability, enzy...

journal_title：Cell biology and toxicology

authors： Prado-Alvarez M,Flórez-Barrós F,Méndez J,Fernandez-Tajes J

更新日期：2013-06-01 00:00:00

abstract：:Interactions between microtubules and filamentous actin (F-actin) are essential to many cellular processes, but their mechanisms are poorly understood. We investigated possible roles of the myosin family of proteins in the interactions between filamentous actin (F-actin) and microtubules of budding yeast Saccharomyces...

journal_title：Cell biology and toxicology

authors： Chon K,Hwang HS,Lee JH,Song K

更新日期：2001-01-01 00:00:00

abstract：:During the last decade, the unbound glutathione content of cultured adherent cells has become a very important biological marker for many pharmacological and toxicological in vitro studies with regard to the protective role of the tripeptide in its reduced form (GSH). However, the literature does not provide extensive...

journal_title：Cell biology and toxicology

authors： Thioudellet C,Oster T,Leroy P,Nicolas A,Wellman M

更新日期：1995-04-01 00:00:00

abstract：:Considering the recent studies that question previously reported cardio-protective effects of estrogen, there is a growing concern that endocrine disruptors may also contribute to the pathology of cardiovascular disease. PCB153 is one of the most commonly found polychlorinated biphenyls, and based on epidemiological s...

journal_title：Cell biology and toxicology

authors： Felty Q

更新日期：2011-02-01 00:00:00

abstract：:The histopathological response and cell culture characteristics of liver cells from the R16 (grc-) strain of rats, which carries an MHC-linked deletion, were examined one week after a single intraperitoneal injection of 200 mg/kg body weight diethylnitrosamine (DEN) and were compared with the response of liver cells f...

journal_title：Cell biology and toxicology

authors： Smith GJ,Kunz HW,Dunsford HA,Gill TJ 3rd

更新日期：1990-04-01 00:00:00

abstract：:Adverse effect of nanoparticles may include impairment of phagocyte function. To identify the effect of nanoparticle size on uptake, cytotoxicity, chemotaxis, cytokine secretion, phagocytosis, oxidative burst, nitric oxide production and myeloperoxidase release, leukocytes isolated from human peripheral blood, monocyt...

journal_title：Cell biology and toxicology

authors： Prietl B,Meindl C,Roblegg E,Pieber TR,Lanzer G,Fröhlich E

更新日期：2014-02-01 00:00:00

abstract：:In a comprehensive assessment of genotoxicity, sodium fluoride was evaluated in a battery of cellular tests providing different genetic end points and biotransformation capabilities. The tests included the following: rat hepatocyte primary culture/DNA repair assay, Salmonella typhimurium histidine locus reversion assa...

journal_title：Cell biology and toxicology

authors： Tong CC,McQueen CA,Brat SV,Williams GM

更新日期：1988-06-01 00:00:00

abstract：:Sister chromatid exchange rate was studied in 12 early diagnosed cases of nasopharyngeal carcinoma and in their paired controls. Exchange frequencies were also analyzed in 100 healthy subjects distributed in four regions of Hunan Province and correlated to nationality, age and sex. The incidence of sister chromatid ex...

journal_title：Cell biology and toxicology

authors： Hu YC,Li GY,Peng L,Deng YM

更新日期：1987-09-01 00:00:00

abstract：:We explored if epigenetic mechanisms could be involved in the down-regulated expression of catalase gene (CAT) in the doxorubicin-resistant acute myelogenous leukemia (AML)-2/DX100 cells. Down-regulated CAT expression in AML-2/DX100 cells was completely recovered after treatment of hydrogen peroxide (H(2)O(2)) and his...

journal_title：Cell biology and toxicology

authors： Lee TB,Moon YS,Choi CH

更新日期：2012-02-01 00:00:00

abstract：:The activity of chemical-induced unscheduled DNA synthesis was evaluated in hepatocyte primary cultures from Fischer 344 and Sprague-Dawley rats over a period of two years. In this two-year study hepatocytes from both sexes and strains were prepared from animals 2, 8, 14, 20 and 25 months of age and UDS was measured b...

journal_title：Cell biology and toxicology

authors： Probst GS,Hill LE

更新日期：1987-06-01 00:00:00

abstract：:Inhibition of endosomal acidification disturbs insulin signaling in both liver and adipose cells. In this study we used MIN6 beta cells to determine whether bafilomycin, a potent inhibitor of the proton-translocating vacuolar ATPase, disrupts insulin signaling in islet beta cells. Pretreatment of MIN6 cells with varyi...

journal_title：Cell biology and toxicology

authors： Hettiarachchi KD,Zimmet PZ,Myers MA

更新日期：2006-05-01 00:00:00

abstract：:Mechanisms of cell death induced by toxins probably involve one or more processes such as inhibition of protein synthesis and impairment of plasma membrane integrity leading to an increase in membrane permeability. Since one of the possible actions of mastoparan, a cationic tetradecapeptide from wasp venom, is to pert...

journal_title：Cell biology and toxicology

authors： Eng SP,Lo CS

更新日期：1990-01-01 00:00:00

abstract：:The lethal toxin of Bacillus anthracis, which is composed of two separate proteinaceous exotoxins, namely protective antigen and lethal factor, is central to the pathogenesis of anthrax. Low levels of this toxin are known to induce release of cytokines such as tumor necrosis factor alpha (TNF-alpha). In the present st...

journal_title：Cell biology and toxicology

authors： Shin S,Hur GH,Kim YB,Yeon GB,Park KJ,Park YM,Lee WS

更新日期：2000-01-01 00:00:00

abstract：:One of the major objectives at the end of this century is the development of "alternative" tests for the evaluation of the pharmacological and/or toxicological activity of newly developed molecules. Contact allergy is no exception to the rule and many research programs have been started to develop in vitro techniques ...

journal_title：Cell biology and toxicology

authors： Lepoittevin JP

更新日期：1999-02-01 00:00:00

abstract：:The use of normal adult liver hepatocytes in cell culture for biochemical, toxicological and pharmacological studies has been greatly limited owing to the loss of replicative capacity and differentiated liver function. This is contrary to the ability of the liver to regenerate following injury in vivo. This suggests t...

journal_title：Cell biology and toxicology

authors： Gibson-D'Ambrosio RE,Crowe DL,Shuler CE,D'Ambrosio SM

更新日期：1993-10-01 00:00:00

abstract：:Rats chronically exposed to acrylonitrile (ACN) have shown a dose-dependent increase in the incidence of astrocytomas in the brain. The mechanism(s) by which ACN induces cancer in rodents has not been established. ACN does not appear to be directly genotoxic in the brain and thus a nongenotoxic mode of action has been...

journal_title：Cell biology and toxicology

authors： Kamendulis LM,Jiang J,Zhang H,deFeijter-Rupp H,Trosko JE,Klaunig JE

更新日期：1999-06-01 00:00:00

abstract：:Health risks associated with the inhalation of potentially toxic materials have been a topic of great public concern. In vitro cellular analyses can provide mechanistic information on the molecular-level responses of lung-derived cell lines to a variety of these hazards. This understanding may be used to develop metho...

journal_title：Cell biology and toxicology

authors： Boesewetter DE,Collier JL,Kim AM,Riley MR

更新日期：2006-03-01 00:00:00

abstract：:Asiatic acid (AA), a triterpene, is known to be cytotoxic to several tumor cell lines. AA induces dose- and time-dependent cell death in U-87 MG human glioblastoma. This cell death occurs via both apoptosis and necrosis. The effect of AA may be cell type-specific as AA-induced cell death was mainly apoptotic in colon ...

journal_title：Cell biology and toxicology

authors： Cho CW,Choi DS,Cardone MH,Kim CW,Sinskey AJ,Rha C

更新日期：2006-11-01 00:00:00

abstract：:Knowledge of the acute toxic effects of chemicals is important for the protection of exposed humans. Since sufficient information in humans is often lacking, experiments on laboratory animals must be performed. The LD50 test, which requires large numbers of animals, has become the preferred procedure. It is now widely...

journal_title：Cell biology and toxicology

authors： Zbinden G

更新日期：1986-09-01 00:00:00

abstract：:The heat-stable enterotoxin (Y-STa) produced by the pathogenic strains of Yersinia enterocolitica is a causative agent of secretory diarrhea. We have reported earlier that Y-STa-induced inositol trisphosphate-mediated cytosolic calcium rise occurs in rat intestinal epithelial cells. In the present communication, the i...

journal_title：Cell biology and toxicology

authors： Saha S,Chowdhury P,Mazumdar A,Pal A,Das P,Chakrabarti MK

更新日期：2009-06-01 00:00:00

abstract：:Oxidative cell injury could be induced by different reactive oxygen species (ROS) operating in multiple pathways. The present work is focused on three different models of oxidative stress: the xanthine/xanthine oxidase system (XXO), an extracellular superoxide anion generator; tert-butylhydroperoxide (TBHP), an analog...

journal_title：Cell biology and toxicology

authors： Fernandes AS,Serejo J,Gaspar J,Cabral F,Bettencourt AF,Rueff J,Castro M,Costa J,Oliveira NG

更新日期：2010-04-01 00:00:00