Abstract:
:Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) as a serious event has high mortality and medical costs. Systemic inflammation and immune response are the major factors influencing the outcome and quality of patient with AECOPD. On basis of identification and validation of AECOPD-specific inflammatory biomarkers, the present study aimed to identify AECOPD-specific immunomodulatory mediators by evaluating dynamic genomic and proteomic profiles of peripheral blood mononuclear cells (PBMCs) and plasma in patients with AECOPD on day 1, 3, and 10 after the hospital admission, to compare with healthy controls or patients with stable COPD. We found that genes and proteins of C1QC and C1RL were co-differentially up-expressed in patients with COPD or AECOPD, while haptoglobin (HP), ORM1, SERPING1, and C3 were identified as a panel of AECOPD-specific immunomodulatory mediators. We also found that inflammatory stimuli could up-regulate osteopontin (OPN)-associated HP expression through the PI3K signal pathway in A549 cells. Block of autocrine production of OPN by gene inhibition could reduce HP production from inflammation-induced lung epithelial cells. The complex network of AECOPD- or COPD-specific immunomodulatory mediators will benefit the development of precision or personalized medicine strategies for prevention and treatment of AECOPD.
journal_name
Cell Biol Toxicoljournal_title
Cell biology and toxicologyauthors
Shi L,Zhu B,Xu M,Wang Xdoi
10.1007/s10565-017-9405-xsubject
Has Abstractpub_date
2018-04-01 00:00:00pages
109-123issue
2eissn
0742-2091issn
1573-6822pii
10.1007/s10565-017-9405-xjournal_volume
34pub_type
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doi:10.1007/s10565-006-0097-x
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pub_type: 杂志文章,已发布勘误
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journal_title:Cell biology and toxicology
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