当前位置： SCI文献检索 > PHYSICS IN MEDICINE AND BIOLOGY期刊下所有文献 > Potential applications of the quantitative susceptibility mapping (QSM) in MR-guided radiation therapy.

Potential applications of the quantitative susceptibility mapping (QSM) in MR-guided radiation therapy.

Abstract：

:Magnetic resonance-guided radiation therapy (MR-GRT) offers great potential to improve radiation treatment outcomes by providing more accurate and patient-tailored therapy. Despite superior soft tissue contrast in MRI, one of the challenges towards MRI-only workflows is that the process often requires some sort of 'MR-invisible' metal-based devices. In this study, the feasibility of quantitative susceptibility mapping (QSM) for visualization of some MR-invisible radiation therapy devices was studied. Our recently proposed QSM-based algorithm for brachytherapy seed visualization was modified and the feasibility of the optimized algorithm for visualization of different devices including: brachytherapy seeds, plastic interstitial needles, CT-markers and obturators, and different types of fiducial markers in agar, prostate and meat phantoms were studied. All phantoms were scanned using 3T MR scanner with a 3D multi-echo gradient recalled echo (ME-GRE) pulse sequence. The QSM results in all phantoms were compared to CT images for spatial accuracy of the QSM. The applied post-processing algorithm was found to be insensitive to the seeds' type; also, presence of nearby calcifications had no effect on seed visualization. QSM successfully generated positive contrast for both types of investigated fiducial markers with high spatial accuracy compared to CT. Interstitial needles containing both aluminum-based CT-maker and titanium-based obturators were accurately depicted on the QSM. The proposed QSM-based technique relies on the standard MR pulse sequences and visualize the conventional MR-invisible metallic devices with CT-like positive contrast solely through post-processing. Upon in vivo validation of the technique, QSM may have the potential to replace CT for an MR-only guided radiation therapy.

journal_name

Phys Med Biol

journal_title

Physics in medicine and biology

authors

Nosrati R,Paudel M,Ravi A,Pejovic-Milic A,Morton G,Stanisz GJ

doi

10.1088/1361-6560/ab2623

subject

Has Abstract

pub_date

2019-07-16 00:00:00

pages

145013

issue

eissn

0031-9155

issn

1361-6560

journal_volume

pub_type

杂志文章

在线工具

Potential applications of the quantitative susceptibility mapping (QSM) in MR-guided radiation therapy.