Abstract：
:We report on a novel method for simultaneous biological optimization of treatment plans for hypoxic tumors using multiple ion species. Our previously introduced kill painting approach, where the overall cell killing is optimized on biologically heterogeneous targets, was expanded with the capability of handling different ion beams simultaneously. The current version (MIBO) of the research treatment planning system TRiP98 has now been augmented to handle 3D (voxel-by-voxel) target oxygenation data. We present a case of idealized geometries where this method can identify optimal combinations leading to an improved peak-to-entrance effective dose ratio. This is achieved by the redistribution of particle fluences, when the heavier ions are preferentially forwarded to hypoxic target areas, while the lighter ions deliver the remaining dose to its normoxic regions. Finally, we present an in silico skull base chordoma patient case study with a combination of 4He and 16O beams, demonstrating specific indications for its potential clinical application. In this particular case, the mean dose, received by the brainstem, was reduced by 3%-5% and by 10%-12% as compared to the pure 4He and 16O plans, respectively. The new method allows a full biological optimization of different ion beams, exploiting the capabilities of actively scanned ion beams of modern particle therapy centers. The possible experimental verification of the present approach at ion beam facilities disposing of fast ion switch is presented and discussed.
journal_name
Phys Med Bioljournal_title
Physics in medicine and biologyauthors
Sokol O,Krämer M,Hild S,Durante M,Scifoni Edoi
10.1088/1361-6560/aafe40subject
Has Abstractpub_date
2019-02-08 00:00:00pages
045008issue
4eissn
0031-9155issn
1361-6560journal_volume
64pub_type
杂志文章abstract：:Using Cherenkov radiation in positron emission tomography (PET) has the potential to improve the time of flight (TOF) resolution and reduce the cost of detectors. In previous studies promising TOF results were achieved when lead fluoride (PbF2) crystals were used instead of a scintillator. In this work, a whole-body P...
journal_title：Physics in medicine and biology
pub_type： 杂志文章
doi：10.1088/1361-6560/ab6f97
更新日期：2020-03-06 00:00:00
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journal_title：Physics in medicine and biology
pub_type： 杂志文章
doi：10.1088/1361-6560/aae658
更新日期：2018-10-29 00:00:00
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journal_title：Physics in medicine and biology
pub_type： 杂志文章
doi：10.1088/0031-9155/61/4/N102
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journal_title：Physics in medicine and biology
pub_type： 杂志文章
doi：10.1088/0031-9155/54/10/002
更新日期：2009-05-21 00:00:00
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journal_title：Physics in medicine and biology
pub_type： 杂志文章
doi：10.1088/1361-6560/ab9fc9
更新日期：2020-08-19 00:00:00
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journal_title：Physics in medicine and biology
pub_type： 杂志文章
doi：10.1088/0031-9155/52/10/N03
更新日期：2007-05-21 00:00:00
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journal_title：Physics in medicine and biology
pub_type： 杂志文章,评审
doi：10.1088/0031-9155/51/13/R09
更新日期：2006-07-07 00:00:00
abstract：:In previous work we demonstrated the potential of positron emission tomography (PET) detectors with depth-of-interaction (DOI) encoding capability based on phosphor-coated crystals. A DOI resolution of 8 mm full-width at half-maximum was obtained for 20 mm long scintillator crystals using a delayed charge integration ...
journal_title：Physics in medicine and biology
pub_type： 杂志文章
doi：10.1088/0031-9155/57/20/6571
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journal_title：Physics in medicine and biology
pub_type： 杂志文章
doi：10.1088/1361-6560/abb1d8
更新日期：2020-11-17 00:00:00
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journal_title：Physics in medicine and biology
pub_type： 杂志文章
doi：10.1088/0031-9155/44/10/315
更新日期：1999-10-01 00:00:00
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journal_title：Physics in medicine and biology
pub_type： 杂志文章
doi：10.1088/0031-9155/49/10/014
更新日期：2004-05-21 00:00:00
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journal_title：Physics in medicine and biology
pub_type： 杂志文章
doi：10.1088/0031-9155/43/8/006
更新日期：1998-08-01 00:00:00
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journal_title：Physics in medicine and biology
pub_type： 杂志文章
doi：10.1088/0031-9155/46/8/302
更新日期：2001-08-01 00:00:00
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journal_title：Physics in medicine and biology
pub_type： 杂志文章
doi：10.1088/0031-9155/53/9/012
更新日期：2008-05-07 00:00:00
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journal_title：Physics in medicine and biology
pub_type： 杂志文章
doi：10.1088/0031-9155/59/20/5987
更新日期：2014-10-21 00:00:00
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journal_title：Physics in medicine and biology
pub_type： 杂志文章
doi：10.1088/0031-9155/30/12/006
更新日期：1985-12-01 00:00:00
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journal_title：Physics in medicine and biology
pub_type： 杂志文章
doi：10.1088/0031-9155/58/2/261
更新日期：2013-01-21 00:00:00
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journal_title：Physics in medicine and biology
pub_type： 杂志文章
doi：10.1088/0031-9155/54/10/019
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journal_title：Physics in medicine and biology
pub_type： 杂志文章
doi：10.1088/0031-9155/57/12/3711
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journal_title：Physics in medicine and biology
pub_type： 杂志文章
doi：10.1088/1361-6560/aa530b
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journal_title：Physics in medicine and biology
pub_type： 杂志文章
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journal_title：Physics in medicine and biology
pub_type： 杂志文章
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journal_title：Physics in medicine and biology
pub_type： 杂志文章
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journal_title：Physics in medicine and biology
pub_type： 评论,信件
doi：10.1088/0031-9155/55/9/L01
更新日期：2010-05-07 00:00:00
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journal_title：Physics in medicine and biology
pub_type： 杂志文章
doi：10.1088/0031-9155/58/24/8689
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journal_title：Physics in medicine and biology
pub_type： 杂志文章
doi：10.1088/1361-6560/62/11/4300
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journal_title：Physics in medicine and biology
pub_type： 杂志文章
doi：10.1088/0031-9155/31/11/006
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journal_title：Physics in medicine and biology
pub_type： 杂志文章
doi：10.1088/0031-9155/60/3/N35
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journal_title：Physics in medicine and biology
pub_type： 杂志文章
doi：10.1088/0031-9155/51/7/006
更新日期：2006-04-07 00:00:00
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journal_title：Physics in medicine and biology
pub_type： 杂志文章
doi：10.1088/1361-6560/ab7503
更新日期：2020-03-23 00:00:00
