In vivo cerebrovascular measurement combining diffuse near-infrared absorption and correlation spectroscopies.

Abstract:

:We combine two near-infrared diffuse optical techniques to study variations of blood flow, haemoglobin concentration, and blood oxygen saturation in the functioning rat brain. Diffuse correlation spectroscopy (or flowmetry) monitors changes in the cerebral blood flow, without the use of the principles of tracer clearance, by measuring the optical phase-shifts caused by moving blood cells. Near-infrared absorption spectroscopy concurrently measures tissue absorption at two wavelengths to determine haemoglobin concentration and blood oxygen saturation in this same tissue volume. This optical probe is non-invasive and was employed through the intact skull. The utility of the technique is demonstrated in vivo by measuring the temporal changes in the regional vascular dynamics of rat brain during hypercapnia. Temporal and spatial variations of cerebral blood flow, haemoglobin concentration and blood oxygen saturation during hypercapnia are compared with other measurements in the literature, and a quantitative analysis demonstrating the self-consistency of our combined observations of vascular response is presented.

journal_name

Phys Med Biol

authors

Cheung C,Culver JP,Takahashi K,Greenberg JH,Yodh AG

doi

10.1088/0031-9155/46/8/302

subject

Has Abstract

pub_date

2001-08-01 00:00:00

pages

2053-65

issue

8

eissn

0031-9155

issn

1361-6560

journal_volume

46

pub_type

杂志文章
  • Multi-view 3D echocardiography compounding based on feature consistency.

    abstract::Echocardiography (echo) is a widely available method to obtain images of the heart; however, echo can suffer due to the presence of artefacts, high noise and a restricted field of view. One method to overcome these limitations is to use multiple images, using the 'best' parts from each image to produce a higher qualit...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/56/18/020

    authors: Yao C,Simpson JM,Schaeffter T,Penney GP

    更新日期:2011-09-21 00:00:00

  • Positron range in PET imaging: an alternative approach for assessing and correcting the blurring.

    abstract::Positron range impairs resolution in PET imaging, especially for high-energy emitters and for small-animal PET. De-blurring in image reconstruction is possible if the blurring distribution is known. Furthermore, the percentage of annihilation events within a given distance from the point of positron emission is releva...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/57/12/3931

    authors: Jødal L,Le Loirec C,Champion C

    更新日期:2012-06-21 00:00:00

  • Measurement of effective detective quantum efficiency for a photon counting scanning mammography system and comparison with two flat panel full-field digital mammography systems.

    abstract::Effective detective quantum efficiency (eDQE) describes the resolution and noise properties of an imaging system along with scatter and primary transmission, all measured under clinically appropriate conditions. Effective dose efficiency (eDE) is the eDQE normalised to mean glandular dose and has been proposed as a us...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/1361-6560/aaa307

    authors: Wood TJ,Moore CS,Saunderson JR,Beavis AW

    更新日期:2018-01-16 00:00:00

  • 1D dynamic beam modulation: methods to counteract inertia effects.

    abstract::Dynamic modulation can be affected by inaccuracies when the required acceleration is larger than the highest allowed by the mechanical characteristics of the whole apparatus. In this study, inertia effects have been investigated with regard to the single absorber 1D modulation, analysing primarily how the acceleration...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/44/11/401

    authors: Corletto D,Broggi S,Fiorino C,Mangili P,Calandrino R,Lev A,Gennari D,Rudello F

    更新日期:1999-11-01 00:00:00

  • Measurement of the absolute optical properties and cerebral blood volume of the adult human head with hybrid differential and spatially resolved spectroscopy.

    abstract::A hybrid differential and spatially resolved spectroscopy (SRS) technique has been developed to measure absolute absorption coefficient (mu(a)), reduced scattering coefficient (mu'(s)) and cerebral blood volume (CBV) in the adult human head. A spectrometer with both differential and SRS capabilities has been used to c...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/51/3/015

    authors: Leung TS,Tachtsidis I,Smith M,Delpy DT,Elwell CE

    更新日期:2006-02-07 00:00:00

  • Computer-aided diagnosis of lung cancer: the effect of training data sets on classification accuracy of lung nodules.

    abstract::This study aims to develop a computer-aided diagnosis (CADx) scheme for classification between malignant and benign lung nodules, and also assess whether CADx performance changes in detecting nodules associated with early and advanced stage lung cancer. The study involves 243 biopsy-confirmed pulmonary nodules. Among ...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/1361-6560/aaa610

    authors: Gong J,Liu JY,Sun XW,Zheng B,Nie SD

    更新日期:2018-02-05 00:00:00

  • Image-based point spread function implementation in a fully 3D OSEM reconstruction algorithm for PET.

    abstract::The interest in positron emission tomography (PET) and particularly in hybrid integrated PET/CT systems has significantly increased in the last few years due to the improved quality of the obtained images. Nevertheless, one of the most important limits of the PET imaging technique is still its poor spatial resolution ...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/55/14/012

    authors: Rapisarda E,Bettinardi V,Thielemans K,Gilardi MC

    更新日期:2010-07-21 00:00:00

  • The sliding slit test for dynamic IMRT: a useful tool for adjustment of MLC related parameters.

    abstract::For treatments with dynamic intensity modulated radiotherapy (IMRT), the adjustment of multileaf collimator (MLC) parameters affecting both the optimization algorithm and dose distributions is crucial. The main parameters characterizing the MLC are the transmission (T) and the dosimetric leaf separation (DLS). The aim...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/50/4/001

    authors: Chauvet I,Petitfils A,Lehobey C,Kristner JY,Brunet Y,Lembrez R,Gaboriaud G,Mazal A,Zefkili S,Rosenwald JC

    更新日期:2005-02-21 00:00:00

  • Estimation of the absorption coefficients of two-layered media by a simple method using spatially and time-resolved reflectances.

    abstract::Our newly developed method using spatially and time-resolved reflectances can easily estimate the absorption coefficients of each layer in a two-layered medium if the thickness of the upper layer and the reduced scattering coefficients of the two layers are known a priori. We experimentally validated this method using...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/54/16/014

    authors: Shimada M,Sato C,Hoshi Y,Yamada Y

    更新日期:2009-08-21 00:00:00

  • Correction for 'artificial' electron disequilibrium due to cone-beam CT density errors: implications for on-line adaptive stereotactic body radiation therapy of lung.

    abstract::Cone-beam computed tomography (CBCT) has rapidly become a clinically useful imaging modality for image-guided radiation therapy. Unfortunately, CBCT images of the thorax are susceptible to artefacts due to scattered photons, beam hardening, lag in data acquisition, and respiratory motion during a slow scan. These limi...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/58/12/4157

    authors: Disher B,Hajdok G,Wang A,Craig J,Gaede S,Battista JJ

    更新日期:2013-06-21 00:00:00

  • Dose measurements in inhomogeneous bone/tissue and lung/tissue phantoms for angiography using synchrotron radiation.

    abstract::For angiography using synchrotron radiation we measured the absorbed dose distribution in inhomogeneous phantoms with thin LiF:Mg, Cu, P, LiF:Mg, Ti thermoluminescent dosimeters (TLDs) in tissue and lung substitutes, and with Mg2SiO4:Tb TLDs in bone substitute for 33.32 keV monoenergetic photons from synchrotron radia...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/46/3/308

    authors: Nariyama N,Namito Y,Ban S,Hirayama H

    更新日期:2001-03-01 00:00:00

  • The biomechanics of simple steatosis and steatohepatitis.

    abstract::Magnetic resonance and ultrasound elastography techniques are now important tools for staging high-grade fibrosis in patients with chronic liver disease. However, uncertainty remains about the effects of simple accumulation of fat (steatosis) and inflammation (steatohepatitis) on the parameters that can be measured us...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/1361-6560/aac09a

    authors: Parker KJ,Ormachea J,Drage MG,Kim H,Hah Z

    更新日期:2018-05-17 00:00:00

  • Multiline 3D beamforming using micro-beamformed datasets for pediatric transesophageal echocardiography.

    abstract::Until now, no matrix transducer has been realized for 3D transesophageal echocardiography (TEE) in pediatric patients. In 3D TEE with a matrix transducer, the biggest challenges are to connect a large number of elements to a standard ultrasound system, and to achieve a high volume rate (>200 Hz). To address these issu...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/1361-6560/aab45e

    authors: Bera D,Raghunathan SB,Chen C,Chen Z,Pertijs MAP,Verweij MD,Daeichin V,Vos HJ,van der Steen AFW,de Jong N,Bosch JG

    更新日期:2018-03-29 00:00:00

  • Filtered back-projection reconstruction for attenuation proton CT along most likely paths.

    abstract::This work investigates the attenuation of a proton beam to reconstruct the map of the linear attenuation coefficient of a material which is mainly caused by the inelastic interactions of protons with matter. Attenuation proton computed tomography (pCT) suffers from a poor spatial resolution due to multiple Coulomb sca...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/61/9/3258

    authors: Quiñones CT,Létang JM,Rit S

    更新日期:2016-05-07 00:00:00

  • End-to-end tests using alanine dosimetry in scanned proton beams.

    abstract::This paper describes end-to-end test procedures as the last fundamental step of medical commissioning before starting clinical operation of the MedAustron synchrotron-based pencil beam scanning (PBS) therapy facility with protons. One in-house homogeneous phantom and two anthropomorphic heterogeneous (head and pelvis)...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/1361-6560/aaac23

    authors: Carlino A,Gouldstone C,Kragl G,Traneus E,Marrale M,Vatnitsky S,Stock M,Palmans H

    更新日期:2018-02-26 00:00:00

  • Evaluation of the basic properties of the BANGkit gel dosimeter.

    abstract::We evaluated the basic properties of a commercially available BANGkit gel dosimeter, which is a normoxic type of BANG gel. This gel-kit has the same composition as the BANG 3 gel, but is fully oxygenated. To exclude oxygen, oxygen scavenging ascorbic acid and copper sulfate as a catalyst are used. The properties that ...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/52/8/017

    authors: Murakami Y,Nakashima T,Watanabe Y,Akimitsu T,Matsuura K,Kenjo M,Kaneyasu Y,Wadasaki K,Hirokawa Y,Ito K

    更新日期:2007-04-21 00:00:00

  • Semi-empirical formulation of multiple scattering for the Gaussian beam model of heavy charged particles stopping in tissue-like matter.

    abstract::Dose calculation for radiotherapy with protons and heavier ions deals with a large volume of path integrals involving a scattering power of body tissue. This work provides a simple model for such demanding applications. There is an approximate linearity between RMS end-point displacement and range of incident particle...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/54/5/N01

    authors: Kanematsu N

    更新日期:2009-03-07 00:00:00

  • Towards clinical application: prompt gamma imaging of passively scattered proton fields with a knife-edge slit camera.

    abstract::Prompt γ-ray imaging with a knife-edge shaped slit camera provides the possibility of verifying proton beam range in tumor therapy. Dedicated experiments regarding the characterization of the camera system have been performed previously. Now, we aim at implementing the prototype into clinical application of monitoring...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/61/22/7881

    authors: Priegnitz M,Barczyk S,Nenoff L,Golnik C,Keitz I,Werner T,Mein S,Smeets J,Vander Stappen F,Janssens G,Hotoiu L,Fiedler F,Prieels D,Enghardt W,Pausch G,Richter C

    更新日期:2016-11-21 00:00:00

  • A comparative EPR, infrared and Raman study of natural and deproteinated tooth enamel and dentin.

    abstract::The aim of the present work was to investigate how the native signal observed in the electron paramagnetic resonance (EPR) spectrum of tooth enamel and dentin is associated with the organic content of the two tissues. This was achieved by comparing the EPR native signal and the optical bands (Raman and infrared, IR) a...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/50/6/004

    authors: Fattibene P,Carosi A,De Coste V,Sacchetti A,Nucara A,Postorino P,Dore P

    更新日期:2005-03-21 00:00:00

  • FDTD analysis of human body-core temperature elevation due to RF far-field energy prescribed in the ICNIRP guidelines.

    abstract::This study investigated the relationship between the specific absorption rate and temperature elevation in an anatomically-based model named NORMAN for exposure to radio-frequency far fields in the ICNIRP guidelines (1998 Health Phys. 74 494-522). The finite-difference time-domain method is used for analyzing the elec...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/52/16/020

    authors: Hirata A,Asano T,Fujiwara O

    更新日期:2007-08-21 00:00:00

  • Experimental determination of pCo perturbation factors for plane-parallel chambers.

    abstract::For plane-parallel chambers used in electron dosimetry, modern dosimetry protocols recommend a cross-calibration against a calibrated cylindrical chamber. The rationale for this is the unacceptably large (up to 3-4%) chamber-to-chamber variations of the perturbation factors (pwall)Co, which have been reported for plan...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章,多中心研究

    doi:10.1088/0031-9155/52/23/026

    authors: Kapsch RP,Bruggmoser G,Christ G,Dohm OS,Hartmann GH,Schüle E

    更新日期:2007-12-07 00:00:00

  • Measuring optical temperature coefficients of Intralipid.

    abstract::The temperature sensitivities of absorption and reduced scattering coefficients in the range 700-1000 nm are determined for the liquid phantom Intralipid using spatially resolved continuous wave measurements. The measurements were conducted on a 10 L heated volume of 1% Intralipid subjected to a 40-30 degrees C coolin...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/52/9/003

    authors: McGlone VA,Martinsen P,Künnemeyer R,Jordan B,Cletus B

    更新日期:2007-05-07 00:00:00

  • Optimization and performance study of a proton CT system for pre-clinical small animal imaging.

    abstract::Proton computed tomography (pCT) promises to reduce or even eliminate range uncertainties inherent in the conversion of Hounsfield units into relative stopping power (RSP) for proton therapy treatment planning. This is of particular interest for proton irradiation studies in animal models due to the high precision req...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/1361-6560/ab8afc

    authors: Meyer S,Bortfeldt J,Lämmer P,Englbrecht FS,Pinto M,Schnürle K,Würl M,Parodi K

    更新日期:2020-08-13 00:00:00

  • The Hug-Kellerer equation as the universal cell survival curve.

    abstract::The Hug-Kellerer (H-K) equation is one of the earliest proposed radiation cell survival curves. We examine this equation in view of the recent perceived need for a universal cell survival curve which would be applicable to single radiation fractions at high doses. We derive relationships between the three parameters o...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/55/10/N01

    authors: Ekstrand KE

    更新日期:2010-05-21 00:00:00

  • Development of an MR-compatible gamma probe for combined MR/RI guided surgery.

    abstract::We have developed and tested an MR-compatible gamma probe to simultaneously obtain anatomical information and functional information during surgery. The probe consists of a probe head, an optical fibre bundle and a photo-multiplier tube (PMT). The NaI(T1) scintillator contained in the probe head is connected to a 7 m ...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/49/15/005

    authors: Yamamoto S,Kuroda K,Senda M

    更新日期:2004-08-07 00:00:00

  • Distributed three-dimensional simulation of B-mode ultrasound imaging using a first-order k-space method.

    abstract::Computational modeling is an important tool in ultrasound imaging research, but realistic three-dimensional (3D) simulations can exceed the capabilities of serial computers. This paper uses a 3D simulator based on a k-space method that incorporates relaxation absorption and nonreflecting boundary conditions. The simul...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/54/17/007

    authors: Daoud MI,Lacefield JC

    更新日期:2009-09-07 00:00:00

  • Initial assessment of a simple system for frequency domain diffuse optical tomography.

    abstract::Diffuse optical tomography is an imaging technique whereby spatial maps of absorption and scattering coefficients are derived from the characteristics of multiply scattered light transmitted through the object. The system described here used four intensity-modulated light sources and measurements of the intensity and ...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/40/10/011

    authors: Pogue BW,Patterson MS,Jiang H,Paulsen KD

    更新日期:1995-10-01 00:00:00

  • Fast dose calculation in magnetic fields with GPUMCD.

    abstract::A new hybrid imaging-treatment modality, the MRI-Linac, involves the irradiation of the patient in the presence of a strong magnetic field. This field acts on the charged particles, responsible for depositing dose, through the Lorentz force. These conditions require a dose calculation engine capable of taking into con...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/56/16/003

    authors: Hissoiny S,Raaijmakers AJ,Ozell B,Després P,Raaymakers BW

    更新日期:2011-08-21 00:00:00

  • Cross-sections for the inactivation of ribonuclease by slow heavy ions.

    abstract::Average cross-sections for inactivation of dry ribonuclease by H, He and N projectiles with energies between 100 eV and 10 keV are presented. The trend of the damage cross-sections with particle energy is consistent with the trend of the molecular quasi-elastic scattering and ionization cross-sections. A tentative rad...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/20/6/005

    authors: Watt DE,Sutcliffe JF

    更新日期:1975-11-01 00:00:00

  • Detector arrangement and sampling characteristics in rotary positron-emission computed tomography.

    abstract::A rotary positron-emission computed tomography system has been proposed in which detectors are mounted unequally spaced on a ring, so as to provide fine and uniform linear sampling during a 360 degree rotation of the ring around its centre. The usefulness of a simple iterative method for searching for a suitable arran...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/26/3/011

    authors: Yamamoto M

    更新日期:1981-05-01 00:00:00