Optimization of MAGIC gel formulation for three-dimensional radiation therapy dosimetry.

Abstract:

:Polymer gel dosimetry aims to provide three-dimensional images of radiation therapy dose distributions in irradiated aqueous gels. The first gels required manufacture in an oxygen-free environment, but later the MAGIC formulation was introduced, which could be made in normal atmospheric conditions. Here we report our studies of the effects of variations in the composition of the MAGIC gel performed in order to optimize its performance over the useful dose range of 0 to 20 Gy. A new formulation (termed 'MAGIC-2') is comprised of 87% water, 4% methacrylic acid, 9% gelatin, 17.38 x 10(-6) M Cu(2+) and a molar ratio of ascorbic acid to [Cu(2+)] of 1000:1. MAGIC-2 has a dose-response slope-to-intercept ratio that is 78% greater than the original formulation and other more favorable properties.

journal_name

Phys Med Biol

authors

Luci JJ,Whitney HM,Gore JC

doi

10.1088/0031-9155/52/10/N03

subject

Has Abstract

pub_date

2007-05-21 00:00:00

pages

N241-8

issue

10

eissn

0031-9155

issn

1361-6560

pii

S0031-9155(07)32701-2

journal_volume

52

pub_type

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