Abstract：
:This work is a follow-up study for a recently-proposed 3D radiochromic gel dosimeter that contains a tetrazolium salt and a physical gel matrix made of poly(ethylene oxide)-block-poly(propylene oxide)-block-poly(ethylene oxide) (Pluronic F-127). Several tetrazolium salts were examined in this work, including tetrazolium violet, blue tetrazolium chloride, nitro blue tetrazolium chloride (NBT), tetranitro blue tetrazolium chloride (tNBT) and thiazolyl blue tetrazolium bromide (TBTB). The salt-containing gel dosimeters were compared with the first Pluronic gel composition that contained 2,3,5-triphenyltetrazolium chloride (TTC) as the radiation-sensitive component (dose sensitivity of 0.0023 (Gy cm)-1). The Pluronic gels with NBT and tNBT outperformed the other gels, including the TTC-containing gel, with respect to their dose sensitivity and low dose-response. The NBT gels were found to have better stability over time than tNBT gels. Sensitization of the gels to ionizing radiation was examined by addition of tert-butyl alcohol and sodium formate. The best composition was 0.0818% NBT (1 mM), 25% Pluronic F-127 and 0.136 × 10-2% sodium formate. This gel dosimeter was insensitive to changes in dose rate for photons of different energies. The mean dose sensitivity amounted to 0.0047 ± 0.1 × 10-4 (Gy cm)-1. A diversion in the dose-response was observed for the gel irradiated with electrons. Additional characteristics of the NBT gel were a linear-dose range and a dynamic-dose range between <1 and ⩾150 Gy and a dose threshold of <1 Gy. The dose distribution registered for the NBT-Pluronic gel was stable after irradiation for over 7 d with no visible diffusion of the irradiated part, which is analogous to the original TTC-Pluronic gel.
journal_name
Phys Med Bioljournal_title
Physics in medicine and biologyauthors
Kwiatos K,Maras P,Kadlubowski S,Stempień Z,Dudek M,Kozicki Mdoi
10.1088/1361-6560/aabbb6subject
Has Abstractpub_date
2018-05-04 00:00:00pages
095012issue
9eissn
0031-9155issn
1361-6560journal_volume
63pub_type
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