当前位置： SCI文献检索 > PHYSICS IN MEDICINE AND BIOLOGY期刊下所有文献 > Monte Carlo simulations to support start-up and treatment planning of scanned proton and carbon ion therapy at a synchrotron-based facility.

Monte Carlo simulations to support start-up and treatment planning of scanned proton and carbon ion therapy at a synchrotron-based facility.

Abstract：

:Reliable treatment planning of highly conformal scanned ion beam therapy demands accurate tools for the determination and characterization of the individual pencil-like beams building up the integral dose delivery and related mixed radiation field. At present, clinically practicable inverse treatment planning systems (TPSs) can only rely on fast-performing analytical algorithms. However, the rapidly emerging though more computationally intensive Monte Carlo (MC) methods can be employed to complement analytical TPS, e.g., via accurate calculations of the input beam-model data, together with a considerable reduction of the measuring time. Here we present the work done for the application of the FLUKA MC code to support several aspects of scanned ion beam delivery and treatment planning at the Heidelberg Ion Beam Therapy Center (HIT). Emphasis is given to the generation of the accelerator library and of experimentally validated TPS input basic data which are now in clinical use for proton and carbon ion therapy. Additionally, MC dose calculations of planned treatments in water are shown to represent a valuable tool for supporting treatment plan verification in comparison to dosimetric measurements. This paper can thus provide useful information and guidelines for the start-up and clinical operation of forthcoming ion beam therapy facilities similar to HIT.

journal_name

Phys Med Biol

journal_title

Physics in medicine and biology

authors

Parodi K,Mairani A,Brons S,Hasch BG,Sommerer F,Naumann J,Jäkel O,Haberer T,Debus J

doi

10.1088/0031-9155/57/12/3759

subject

Has Abstract

pub_date

2012-06-21 00:00:00

pages

3759-84

issue

12

eissn

0031-9155

issn

1361-6560

journal_volume

57

pub_type

杂志文章

相关文献

PHYSICS IN MEDICINE AND BIOLOGY文献大全
  • Mucosal deformation from an impinging transonic gas jet and the ballistic impact of microparticles.

    abstract：:By means of a transonic gas jet, gene guns ballistically deliver microparticle formulations of drugs and vaccines to the outer layers of the skin or mucosal tissue to induce unique physiological responses for the treatment of a range of conditions. Reported high-speed imaging experiments show that the mucosa deforms s...

    journal_title：Physics in medicine and biology

    pub_type： 杂志文章

    doi：10.1088/0031-9155/50/19/010

    authors： Hardy MP,Kendall MA

    更新日期：2005-10-07 00:00:00

  • New materials for dielectric simulation of tissues.

    abstract：:Two novel materials have been developed to simulate the dielectric properties of human muscle and fat at 1000 MHz. These materials, which are based on ethanediol set with gelatine, are easily made and have good mechanical properties. The complex permittivity, epsilon *, of each material was measured with an open-ended...

    journal_title：Physics in medicine and biology

    pub_type： 杂志文章

    doi：10.1088/0031-9155/36/12/002

    authors： Robinson MP,Richardson MJ,Green JL,Preece AW

    更新日期：1991-12-01 00:00:00

  • Large blood vessel cooling in heated tissues: a numerical study.

    abstract：:Large blood vessels can produce steep temperature gradients in heated tissues leading to inadequate tissue temperatures during hyperthermia. This paper utilizes a finite difference scheme to solve the basic equations of heat transfer and fluid flow to model blood vessel cooling. Unlike previous formulations, heat tran...

    journal_title：Physics in medicine and biology

    pub_type： 杂志文章

    doi：10.1088/0031-9155/40/4/001

    authors： Kolios MC,Sherar MD,Hunt JW

    更新日期：1995-04-01 00:00:00

  • Response, thermal regulatory threshold and thermal breakdown threshold of restrained RF-exposed mice at 905 MHz.

    abstract：:The objective of this study was the determination of the thermal regulatory and the thermal breakdown thresholds for in-tube restrained B6C3F1 and NMRI mice exposed to radiofrequency electromagnetic fields at 905 MHz. Different levels of the whole-body averaged specific absorption rate (SAR = 0, 2, 5, 7.2, 10, 12.6 an...

    journal_title：Physics in medicine and biology

    pub_type： 杂志文章

    doi：10.1088/0031-9155/50/21/017

    authors： Ebert S,Eom SJ,Schuderer J,Apostel U,Tillmann T,Dasenbrock C,Kuster N

    更新日期：2005-11-07 00:00:00

  • A comparison of direct reconstruction algorithms in proton computed tomography.

    abstract：:Several direct algorithms have been proposed to take into account the non-linear path of protons in the reconstruction of a proton CT (pCT) image. This paper presents a comparison between five of them, in terms of spatial resolution and relative stopping power (RSP) accuracy. Our comparison includes (1) a distance-dri...

    journal_title：Physics in medicine and biology

    pub_type： 杂志文章

    doi：10.1088/1361-6560/ab7d53

    authors： Khellaf F,Krah N,Létang JM,Collins-Fekete CA,Rit S

    更新日期：2020-06-01 00:00:00

  • Organ and effective doses in newborn patients during helical multislice computed tomography examination.

    abstract：:In this study, two computational phantoms of the newborn patient were used to assess individual organ doses and effective doses delivered during head, chest, abdomen, pelvis, and torso examinations using the Siemens SOMATOM Sensation 16 helical multi-slice computed tomography (MSCT) scanner. The stylized phantom used ...

    journal_title：Physics in medicine and biology

    pub_type： 杂志文章

    doi：10.1088/0031-9155/51/20/005

    authors： Staton RJ,Lee C,Lee C,Williams MD,Hintenlang DE,Arreola MM,Williams JL,Bolch WE

    更新日期：2006-10-21 00:00:00

  • Optimization of magnetic flux density measurement using multiple RF receiver coils and multi-echo in MREIT.

    abstract：:Magnetic Resonance Electrical Impedance Tomography (MREIT) is an MRI method that enables mapping of internal conductivity and/or current density via measurements of magnetic flux density signals. The MREIT measures only the z-component of the induced magnetic flux density B = (Bx, By, Bz) by external current injection...

    journal_title：Physics in medicine and biology

    pub_type： 杂志文章

    doi：10.1088/0031-9155/59/17/4827

    authors： Jeong WC,Chauhan M,Sajib SZ,Kim HJ,Serša I,Kwon OI,Woo EJ

    更新日期：2014-09-07 00:00:00

  • A new optimal wavelength for treatment of port wine stains?

    abstract：:In this study we investigate light penetration into skin in order to define the optimal wavelength for the treatment of port wine stains. A two-layer model (epidermis and dermis) is applied with a cylindric tube representing the ectatic blood vessel. Light propagation is calculated by the Monte Carlo method. Values fo...

    journal_title：Physics in medicine and biology

    pub_type： 杂志文章

    doi：10.1088/0031-9155/40/10/001

    authors： Kienle A,Hibst R

    更新日期：1995-10-01 00:00:00

  • Direct detection of 6 MV x-rays from a medical linear accelerator using a semiconducting polymer diode.

    abstract：:Recently, a new family of low-cost x-radiation detectors have been developed, based on semiconducting polymer diodes, which are easy to process, mechanically flexible, relatively inexpensive, and able to cover large areas. To test their potential for radiotherapy applications such as beam monitors or dosimeters, as an...

    journal_title：Physics in medicine and biology

    pub_type： 杂志文章

    doi：10.1088/0031-9155/58/13/4471

    authors： Mills CA,Chan YF,Intaniwet A,Shkunov M,Nisbet A,Keddie JL,Sellin PJ

    更新日期：2013-07-07 00:00:00

  • A motion-incorporated reconstruction method for gated PET studies.

    abstract：:Cardiac and respiratory motion artefacts in PET imaging have been traditionally resolved by acquiring the data in gated mode. However, gated PET images are usually characterized by high noise content due to their low photon statistics. In this paper, we present a novel 4D model for the PET imaging system, which can in...

    journal_title：Physics in medicine and biology

    pub_type： 杂志文章

    doi：10.1088/0031-9155/51/15/012

    authors： Qiao F,Pan T,Clark JW Jr,Mawlawi OR

    更新日期：2006-08-07 00:00:00

  • Optimization of image quality and dose for Varian aS500 electronic portal imaging devices (EPIDs).

    abstract：:This study was carried out to investigate whether the electronic portal imaging (EPI) acquisition process could be optimized, and as a result tolerance and action levels be set for the PIPSPro QC-3V phantom image quality assessment. The aim of the optimization process was to reduce the dose delivered to the patient wh...

    journal_title：Physics in medicine and biology

    pub_type： 杂志文章

    doi：10.1088/0031-9155/52/23/006

    authors： McGarry CK,Grattan MW,Cosgrove VP

    更新日期：2007-12-07 00:00:00

  • Biological dose representation for carbon-ion radiotherapy of unconventional fractionation.

    abstract：:In carbon-ion radiotherapy, single-beam delivery each day in alternate directions has been common practice for efficient operation, taking advantage of the Bragg peak and the relative biological effectiveness (RBE) for uniform dose conformation to a tumor. Treatments are usually fractionated and treatment plans are ev...

    journal_title：Physics in medicine and biology

    pub_type： 杂志文章

    doi：10.1088/1361-6560/62/3/1062

    authors： Kanematsu N,Inaniwa T

    更新日期：2017-02-07 00:00:00

  • Improving single-event proton CT by removing nuclear interaction events within the energy/range detector.

    abstract：:Data filtering is crucial for accurate relative stopping power (RSP) reconstruction in proton CT (pCT). In this work, we assess different filters and their performance for the US pCT collaboration prototype pCT system in Monte Carlo (MC) simulations. The potential of using the recently proposed [Formula: see text]-E f...

    journal_title：Physics in medicine and biology

    pub_type： 杂志文章

    doi：10.1088/1361-6560/ab2671

    authors： Volz L,Piersimoni P,Johnson RP,Bashkirov VA,Schulte RW,Seco J

    更新日期：2019-08-01 00:00:00

  • A hybrid scatter correction for 3D PET based on an estimation of the distribution of unscattered coincidences: implementation on the ECAT EXACT HR+.

    abstract：:We implemented a hybrid scatter-correction method for 3D PET that combines two scatter-correction methods in a complementary way. The implemented scheme uses a method based on the discrimination of the energy of events (the estimation of trues method (ETM)) and an auxiliary method (the single scatter simulation method...

    journal_title：Physics in medicine and biology

    pub_type： 杂志文章

    doi：10.1088/0031-9155/47/9/310

    authors： Ferreira NC,Trébossen R,Lartizien C,Brulon V,Merceron P,Bendriem B

    更新日期：2002-05-07 00:00:00

  • End-to-end tests using alanine dosimetry in scanned proton beams.

    abstract：:This paper describes end-to-end test procedures as the last fundamental step of medical commissioning before starting clinical operation of the MedAustron synchrotron-based pencil beam scanning (PBS) therapy facility with protons. One in-house homogeneous phantom and two anthropomorphic heterogeneous (head and pelvis)...

    journal_title：Physics in medicine and biology

    pub_type： 杂志文章

    doi：10.1088/1361-6560/aaac23

    authors： Carlino A,Gouldstone C,Kragl G,Traneus E,Marrale M,Vatnitsky S,Stock M,Palmans H

    更新日期：2018-02-26 00:00:00

  • Development of a platform for co-registered ultrasound and MR contrast imaging in vivo.

    abstract：:Imaging of the microvasculature is often performed using contrast agents in combination with either ultrasound (US) or magnetic resonance (MR) imaging. Contrast agents are used to enhance medical imaging by highlighting microvascular properties and function. Dynamic signal changes arising from the passage of contrast ...

    journal_title：Physics in medicine and biology

    pub_type： 杂志文章

    doi：10.1088/0031-9155/56/3/020

    authors： Chandrana C,Bevan P,Hudson J,Pang I,Burns P,Plewes D,Chopra R

    更新日期：2011-02-07 00:00:00

  • First in-beam PET measurement of beta+ radioactivity induced by hard photon beams.

    abstract：:In this note, we present the first experimental results of in-beam PET measurements during high energy photon phantom irradiation. An inhomogeneous phantom was irradiated with pulsed 34 MV bremsstrahlung. The measurements have been conducted with a dedicated double head positron camera. A high material contrast could ...

    journal_title：Physics in medicine and biology

    pub_type： 杂志文章

    doi：10.1088/0031-9155/52/20/N01

    authors： Kluge T,Möckel D,Pawelke J,Enghardt W

    更新日期：2007-10-21 00:00:00

  • An FDK-like cone-beam SPECT reconstruction algorithm for non-uniform attenuated projections acquired using a circular trajectory.

    abstract：:In this paper, Novikov's inversion formula of the attenuated two-dimensional (2D) Radon transform is applied to the reconstruction of attenuated fan-beam projections acquired with equal detector spacing and of attenuated cone-beam projections acquired with a flat planar detector and circular trajectory. The derivation...

    journal_title：Physics in medicine and biology

    pub_type： 杂志文章

    doi：10.1088/0031-9155/50/10/010

    authors： Huang Q,Zeng GL,You J,Gullberg GT

    更新日期：2005-05-21 00:00:00

  • Imaging placental function: current technology, clinical needs, and emerging modalities.

    abstract：:The function of the placenta is challenging to characterize and as a result is understudied, despite the growing awareness of the impact of the placental environment on human health and development. Medical imaging has the potential to improve our ability to screen for diseases associated with placental insufficiency,...

    journal_title：Physics in medicine and biology

    pub_type： 杂志文章,评审

    doi：10.1088/1361-6560/aaccd9

    authors： Wu C,Bayer CL

    更新日期：2018-07-09 00:00:00

  • A unified analysis of FBP-based algorithms in helical cone-beam and circular cone- and fan-beam scans.

    abstract：:A circular scanning trajectory is and will likely remain a popular choice of trajectory in computed tomography (CT) imaging because it is easy to implement and control. Filtered-backprojection (FBP)-based algorithms have been developed previously for approximate and exact reconstruction of the entire image or a region...

    journal_title：Physics in medicine and biology

    pub_type： 杂志文章

    doi：10.1088/0031-9155/49/18/011

    authors： Pan X,Xia D,Zou Y,Yu L

    更新日期：2004-09-21 00:00:00

  • Characterization of enzymatically induced degradation of articular cartilage using high frequency ultrasound.

    abstract：:Ultrasound may provide a quantitative technique for the characterization of cartilage changes typical of early osteoarthrosis. In this study, specific changes in bovine articular cartilage were induced using collagenase and chondroitinase ABC, enzymes that selectively degrade collagen fibril network and digest proteog...

    journal_title：Physics in medicine and biology

    pub_type： 杂志文章

    doi：10.1088/0031-9155/44/11/303

    authors： Töyräs J,Rieppo J,Nieminen MT,Helminen HJ,Jurvelin JS

    更新日期：1999-11-01 00:00:00

  • Stability analysis of a deterministic dose calculation for MRI-guided radiotherapy.

    abstract：:Modern effort in radiotherapy to address the challenges of tumor localization and motion has led to the development of MRI guided radiotherapy technologies. Accurate dose calculations must properly account for the effects of the MRI magnetic fields. Previous work has investigated the accuracy of a deterministic linear...

    journal_title：Physics in medicine and biology

    pub_type： 杂志文章

    doi：10.1088/1361-6560/aa959a

    authors： Zelyak O,Fallone BG,St-Aubin J

    更新日期：2017-12-14 00:00:00

  • Laser speckle imaging of blood flow in microcirculation.

    abstract：:Monitoring the spatio-temporal characteristics of microcirculation is crucial for studying the functional activities of biotissue and the mechanism of disease. However, conventional methods used to measure blood flow suffer from limited spatial resolution or the injection of exogenous substances or the need of scannin...

    journal_title：Physics in medicine and biology

    pub_type： 杂志文章

    doi：10.1088/0031-9155/49/7/020

    authors： Cheng H,Luo Q,Liu Q,Lu Q,Gong H,Zeng S

    更新日期：2004-04-07 00:00:00

  • Development and comparison of computer methods for organ motion correction in scintigraphy.

    abstract：:The process of organ motion correction in scintigraphy is analysed in the frequency domain. The sequence of the chi- and gamma- coordinates registered during scintigraphic recording is converted to a frequency spectrum by a discrete Fourier transform. In the frequency domain motion correction is performed by linear fi...

    journal_title：Physics in medicine and biology

    pub_type： 杂志文章

    doi：10.1088/0031-9155/20/3/010

    authors： Schmidlin P

    更新日期：1975-05-01 00:00:00

  • Thresholds for visual detection of Young's modulus contrast in simulated ultrasound image movies.

    abstract：:Elasticity imaging (EI) is being developed to allow the evaluation of the mechanical properties of soft tissue, but these properties are already assessed in routine ultrasound breast examination using a method that involves the subjective interpretation of tissue motion seen in real-time B-mode image movies during pal...

    journal_title：Physics in medicine and biology

    pub_type： 杂志文章

    doi：10.1088/0031-9155/45/8/301

    authors： Miller NR,Bamber JC

    更新日期：2000-08-01 00:00:00

  • A novel approach with dual-sampling convolutional neural network for ultrasound image classification of breast tumors.

    abstract：:Breast cancer is one of the leading causes of female cancer deaths. Early diagnosis with prophylactic may improve the patients' prognosis. So far ultrasound (US) imaging is a popular method in breast cancer diagnosis. However, its accuracy is bounded to traditional handcrafted feature methods and expertise. A novel me...

    journal_title：Physics in medicine and biology

    pub_type： 杂志文章

    doi：10.1088/1361-6560/abc5c7

    authors： Xie J,Song X,Zhang W,Dong Q,Wang Y,Li F,Wan C

    更新日期：2020-10-29 00:00:00

  • An investigation of factors affecting the accuracy of in vivo measurements of skin pigments by reflectance spectrophotometry.

    abstract：:Factors affecting the accuracy of the in vivo measurement of cutaneous pigments and blood oxygenation by reflectance spectrophotometry have been examined. It was found that stray light, the amounts of haemoglobin and melanin, and the level of blood oxygenation all contributed to the measured reflectance and had to be ...

    journal_title：Physics in medicine and biology

    pub_type： 杂志文章

    doi：10.1088/0031-9155/35/9/009

    authors： Hajizadeh-Saffar M,Feather JW,Dawson JB

    更新日期：1990-09-01 00:00:00

  • Pre- and post-natal exposure of children to EMF generated by domestic induction cookers.

    abstract：:Induction cookers are a type of cooking appliance that uses an intermediate-frequency magnetic field to heat the cooking vessel. The magnetic flux density produced by an induction cooker during operation was measured according to the EN 62233 standard, and the measured values were below the limits set in the standard....

    journal_title：Physics in medicine and biology

    pub_type： 杂志文章

    doi：10.1088/0031-9155/56/19/001

    authors： Kos B,Valič B,Miklavčič D,Kotnik T,Gajšek P

    更新日期：2011-10-07 00:00:00

  • A technique for the fast calculation of three-dimensional photon dose distributions using the superposition model.

    abstract：:Techniques for reducing computation time in 3D photon dose calculations are addressed with specific emphasis given to the convolution/superposition approach. A single polyenergetic superposition model calculating absorbed dose per incident photon fluence (Gy cm2) was developed in terms of TERMA and a total energy depo...

    journal_title：Physics in medicine and biology

    pub_type： 杂志文章

    doi：10.1088/0031-9155/42/8/001

    authors： Aspradakis MM,Redpath AT

    更新日期：1997-08-01 00:00:00

  • Iterative volume morphing and learning for mobile tumor based on 4DCT.

    abstract：:During image-guided cancer radiation treatment, three-dimensional (3D) tumor volumetric information is important for treatment success. However, it is typically not feasible to image a patient's 3D tumor continuously in real time during treatment due to concern over excessive patient radiation dose. We present a new i...

    journal_title：Physics in medicine and biology

    pub_type： 杂志文章

    doi：10.1088/1361-6560/aa56b2

    authors： Mao S,Wu H,Sandison G,Fang S

    更新日期：2017-02-21 00:00:00