Abstract:
:By means of a transonic gas jet, gene guns ballistically deliver microparticle formulations of drugs and vaccines to the outer layers of the skin or mucosal tissue to induce unique physiological responses for the treatment of a range of conditions. Reported high-speed imaging experiments show that the mucosa deforms significantly while subjected to an impinging gas jet from a biolistic device. In this paper, the effect of this tissue surface deformation on microparticle impact conditions is simulated with computational fluid dynamics (CFD) calculations. The microparticles are idealized as spheres of diameters 26.1, 39 and 99 microm and a density of 1050 kg m-3. Deforming surface calculations of particle impact conditions are compared directly with an immobile surface case. The relative velocity and obliquity of the deforming surface decrease the normal component of particle impact velocity by up to 30% at the outer edge of the impinging gas jet. This is qualitatively consistent with reported particle penetration profiles in the tissue. It is recommended that these effects be considered in biolistic studies requiring quantified particle impact conditions.
journal_name
Phys Med Bioljournal_title
Physics in medicine and biologyauthors
Hardy MP,Kendall MAdoi
10.1088/0031-9155/50/19/010subject
Has Abstractpub_date
2005-10-07 00:00:00pages
4567-80issue
19eissn
0031-9155issn
1361-6560pii
S0031-9155(05)92403-2journal_volume
50pub_type
杂志文章abstract::A new system has been designed and built to validate the concept of 3D computerized angiography (CA). This system can acquire a set of 2D digital subtracted angiography images while rotating around a patient and then, using these images, reconstruct a 3D representation of the opacified vasculature. The design principl...
journal_title:Physics in medicine and biology
pub_type: 杂志文章
doi:10.1088/0031-9155/39/3/020
更新日期:1994-03-01 00:00:00
abstract::The external radiation exposure from an overhead plume containing gamma emitting radionuclides can contribute substantial dose to the ground receptor during normal operations as well as accidental release conditions of nuclear facilities. In order to estimate the effective dose conversion coefficients (DCCs) directly,...
journal_title:Physics in medicine and biology
pub_type: 杂志文章
doi:10.1088/1361-6560/ab2c92
更新日期:2019-08-01 00:00:00
abstract::The 50-year tenure of Physics in Medicine and Biology has coincided with some of the most important developments in radiological science, including the introduction of artificial radioactivity, computers and 3D imaging into medicine. These events have profoundly influenced the development of brachytherapy. Although it...
journal_title:Physics in medicine and biology
pub_type: 杂志文章,评审
doi:10.1088/0031-9155/51/13/R18
更新日期:2006-07-07 00:00:00
abstract::Diffusion tensor - magnetic resonance electrical impedance tomography (DT-MREIT) is an imaging modality to obtain low-frequency anisotropic conductivity distribution employing diffusion tensor imaging (DTI) and magnetic resonance electrical impedance tomography (MREIT) techniques. DT-MREIT is based on the linear relat...
journal_title:Physics in medicine and biology
pub_type: 杂志文章
doi:10.1088/1361-6560/abddcf
更新日期:2021-01-20 00:00:00
abstract::The use of thermographic techniques has increased as infrared detector technology has evolved and improved. For laser-tissue interactions, thermal cameras have been used to monitor the thermal response of tissue to pulsed and continuous wave irradiation. It is important to note that the temperature indicated by the th...
journal_title:Physics in medicine and biology
pub_type: 杂志文章
doi:10.1088/0031-9155/45/2/319
更新日期:2000-02-01 00:00:00
abstract::The free space method using a pair of lens antennas was modified for the complex permittivity measurement of biological samples from 20 to 110 GHz. Two methodologies were used to obtain the complex permittivities by the free space method, which were based on the reflection and transmission coefficients. The measuremen...
journal_title:Physics in medicine and biology
pub_type: 杂志文章
doi:10.1088/0031-9155/58/5/1625
更新日期:2013-03-07 00:00:00
abstract::A theoretical analysis and numerical solutions are presented for viscosity-dominated flow through a uniform, highly distensible tube with a slit-shaped cross section undergoing peristalsis. At flow rates below an intrinsic upper limit to the peristaltic carrying capacity of the tube, provided that there is always at l...
journal_title:Physics in medicine and biology
pub_type: 杂志文章
doi:10.1088/0031-9155/32/7/002
更新日期:1987-07-01 00:00:00
abstract::Mechanical properties of biological tissues are significant biomarkers for diagnosing various diseases. Assessing the viscoelastic properties of multi-layer tissues has remained challenging for a long time. Some shear wave models have been proposed to estimate thin-layer tissues' viscoelasticity recently. However, the...
journal_title:Physics in medicine and biology
pub_type: 杂志文章
doi:10.1088/1361-6560/abca04
更新日期:2020-11-12 00:00:00
abstract::Segmented attenuation correction is now a widely accepted technique to reduce noise propagation from transmission scanning in positron emission tomography (PET). In this paper, we present a new method for segmenting transmission images in whole-body scanning. This reduces the noise in the correction maps while still c...
journal_title:Physics in medicine and biology
pub_type: 杂志文章
doi:10.1088/0031-9155/47/7/310
更新日期:2002-04-07 00:00:00
abstract::Kilo-voltage (KV) cone-beam computed tomography (CBCT) unit mounted onto a linear accelerator treatment system, often referred to as on-board imager (OBI), plays an increasingly important role in image-guided radiation therapy. While the FDK algorithm is currently used for reconstructing images from clinical OBI data,...
journal_title:Physics in medicine and biology
pub_type: 杂志文章
doi:10.1088/0031-9155/60/12/4601
更新日期:2015-06-21 00:00:00
abstract::The treatment of large tumors such as sarcomas with intra-operative radiotherapy using a Mobetron is often complicated because of the limited field size of the primary collimator and the available applicators (max Ø100 mm). To circumvent this limitation a prototype rectangular applicator of 80 x 150 mm(2) was designed...
journal_title:Physics in medicine and biology
pub_type: 杂志文章
doi:10.1088/0031-9155/53/8/006
更新日期:2008-04-21 00:00:00
abstract::In recent years, particle therapy has become a widely accepted form of cancer treatment and technological advances in beam delivery technology (i.e. pencil beam scanning (PBS)) have enabled the application of highly conformal dose distributions to static targets. Current research focuses on the possibilities for the t...
journal_title:Physics in medicine and biology
pub_type: 杂志文章
doi:10.1088/0031-9155/58/22/7905
更新日期:2013-11-21 00:00:00
abstract::Diffraction-enhanced imaging (DEI) is an analyser-based x-ray imaging method that produces separate images depicting the projected x-ray absorption and refractive properties of an object. Because the imaging model of DEI does not account for ultra-small-angle x-ray scattering (USAXS), the images produced in DEI can co...
journal_title:Physics in medicine and biology
pub_type: 杂志文章
doi:10.1088/0031-9155/52/7/011
更新日期:2007-04-07 00:00:00
abstract::In this study, the safety compliance for nonuniform field exposures is discussed using coupling factor concepts. The coupling factor, which is defined in the International Electrotechnical Commission 62311 standard, is extended to consider the effects of harmonics and also to apply to the specific absorption rate (for...
journal_title:Physics in medicine and biology
pub_type: 杂志文章
doi:10.1088/0031-9155/60/20/8129
更新日期:2015-10-21 00:00:00
abstract::In fully three-dimensional PET imaging, iterative image reconstruction techniques usually outperform analytical algorithms in terms of image quality provided that an appropriate system model is used. In this study we concentrate on the calculation of an accurate system model for the YAP-(S)PET II small animal scanner,...
journal_title:Physics in medicine and biology
pub_type: 杂志文章
doi:10.1088/0031-9155/58/19/6713
更新日期:2013-10-07 00:00:00
abstract::The aim of this study was to evaluate angiogenic compositions and tumour response in the course of neoadjuvant chemotherapy in patients with locally advanced breast cancer (LABC) using dynamic contrast-enhanced (DCE) MRI. Thirteen patients with LABC underwent serial DCE MRI during the course of chemotherapy. DCE MRI w...
journal_title:Physics in medicine and biology
pub_type: 杂志文章
doi:10.1088/0031-9155/49/16/007
更新日期:2004-08-21 00:00:00
abstract::The relative stopping power (RSP) uncertainty is the largest contributor to the range uncertainty in proton therapy. The purpose of this work was to develop a systematic method that yields accurate and patient-specific RSPs by combining (1) pre-treatment x-ray CT and (2) daily proton radiography of the patient. The me...
journal_title:Physics in medicine and biology
pub_type: 杂志文章
doi:10.1088/1361-6560/aa7c42
更新日期:2017-08-03 00:00:00
abstract::The aim of the present work was to implement the kinetics of cisplatin into a previously developed tumour growth model and to simulate the combined cisplatin-radiotherapy treatment with the emphasis on time sequencing and scheduling of drug and radiation. An investigation into whether the effect of cisplatin-radiation...
journal_title:Physics in medicine and biology
pub_type: 杂志文章
doi:10.1088/0031-9155/51/15/002
更新日期:2006-08-07 00:00:00
abstract::The aim of this study is the evaluation of on-the-fly volume of intersection computation for system's geometry modelling in 3D PET image reconstruction. For this purpose we propose a simple geometrical model in which the cubic image voxels on the given Cartesian grid are approximated with spheres and the rectangular t...
journal_title:Physics in medicine and biology
pub_type: 杂志文章
doi:10.1088/0031-9155/59/3/561
更新日期:2014-02-07 00:00:00
abstract::The delivery of volumetric modulated arc therapy (VMAT) requires the simultaneous movement of the linear accelerator gantry, multi-leaf collimators and jaws while the dose rate is varied. In this study, a VMAT delivery emulator was developed to accurately predict the characteristics of a given treatment plan, incorpor...
journal_title:Physics in medicine and biology
pub_type: 杂志文章
doi:10.1088/0031-9155/56/13/024
更新日期:2011-07-07 00:00:00
abstract::In a recent paper (Chamberland et al 2016 Phys. Med. Biol. 61 8214) develop a new Monte Carlo code called egs_brachy for brachytherapy treatments. It is based on EGSnrc, and written in the C++ programming language. In order to benchmark the egs_brachy code, the authors use it in various test case scenarios in which co...
journal_title:Physics in medicine and biology
pub_type: 评论,杂志文章,信件
doi:10.1088/1361-6560/aa9ea1
更新日期:2018-02-02 00:00:00
abstract::We have developed deformable and durable optical tissue phantoms with a simple and well-defined microstructure including a novel combination of scatterers and a matrix material. These were developed for speckle and elastography investigations in optical coherence tomography, but should prove useful in many other field...
journal_title:Physics in medicine and biology
pub_type: 杂志文章
doi:10.1088/0031-9155/53/13/N01
更新日期:2008-07-07 00:00:00
abstract::We introduce a novel x-ray imaging approach that yields information about the local texture of structures smaller than the image pixel resolution inside an object. The approach is based on a recently developed x-ray dark-field imaging technique, using scattering from sub-micron structures in the sample. We show that t...
journal_title:Physics in medicine and biology
pub_type: 杂志文章
doi:10.1088/0031-9155/55/12/004
更新日期:2010-06-21 00:00:00
abstract::This study aims at investigating in real-time the structural and dynamical changes occurring in an ex vivo tissue during a microwave thermal ablation (MTA) procedure. The experimental set-up was based on ex vivo liver tissue inserted in a dedicated box, in which 3 fibre-optic (FO) temperature probes were introduced to...
journal_title:Physics in medicine and biology
pub_type: 杂志文章
doi:10.1088/1361-6560/ab1a67
更新日期:2019-05-31 00:00:00
abstract::We propose a completely automated algorithm for the detection of the spinal centreline and the centres of vertebral bodies and intervertebral discs in images acquired by computed tomography (CT) and magnetic resonance (MR) imaging. The developed methods are based on the analysis of the geometry of spinal structures an...
journal_title:Physics in medicine and biology
pub_type: 杂志文章
doi:10.1088/0031-9155/55/1/015
更新日期:2010-01-07 00:00:00
abstract::An expression for the noise power spectrum of images reconstructed by the discrete filtered backprojection algorithm has been derived. The formulation explicitly includes sampling within the projections, angular sampling, and the two-dimensional sampling implicit in the discrete representation of the image. The effect...
journal_title:Physics in medicine and biology
pub_type: 杂志文章
doi:10.1088/0031-9155/32/5/003
更新日期:1987-05-01 00:00:00
abstract::We have numerically modelled the thermal effects of yellow (577 or 578 nm) light illumination on the ectatic blood vessels of port wine stains. We investigated the effect of the laser treatment parameters of light irradiance and illumination time on the extent of coagulation (coagulation thickness) of the endothelial ...
journal_title:Physics in medicine and biology
pub_type: 杂志文章
doi:10.1088/0031-9155/34/9/010
更新日期:1989-09-01 00:00:00
abstract::Breast cancer is one of the leading causes of female cancer deaths. Early diagnosis with prophylactic may improve the patients' prognosis. So far ultrasound (US) imaging is a popular method in breast cancer diagnosis. However, its accuracy is bounded to traditional handcrafted feature methods and expertise. A novel me...
journal_title:Physics in medicine and biology
pub_type: 杂志文章
doi:10.1088/1361-6560/abc5c7
更新日期:2020-10-29 00:00:00
abstract::Respiratory motion in emission tomography leads to reduced image quality. Developed correction methodology has been concentrating on the use of respiratory synchronized acquisitions leading to gated frames. Such frames, however, are of low signal-to-noise ratio as a result of containing reduced statistics. In this wor...
journal_title:Physics in medicine and biology
pub_type: 杂志文章
doi:10.1088/0031-9155/52/17/006
更新日期:2007-09-07 00:00:00
abstract::Percutaneous coronary interventions are associated with increased radiation exposure compared to most radiological examinations. This prospective study aimed at (1) measuring entrance doses for all in-room personnel, (2) performing an assessment of patient effective dose and intracoronary doses, (3) investigating the ...
journal_title:Physics in medicine and biology
pub_type: 临床试验,杂志文章
doi:10.1088/0031-9155/48/18/307
更新日期:2003-09-21 00:00:00