Fuzzy clustering-based segmented attenuation correction in whole-body PET imaging.

Abstract:

:Segmented attenuation correction is now a widely accepted technique to reduce noise propagation from transmission scanning in positron emission tomography (PET). In this paper, we present a new method for segmenting transmission images in whole-body scanning. This reduces the noise in the correction maps while still correcting for differing attenuation coefficients of specific tissues. Based on the fuzzy C-means (FCM) algorithm, the method segments the PET transmission images into a given number of clusters to extract specific areas of differing attenuation such as air, the lungs and soft tissue, preceded by a median filtering procedure. The reconstructed transmission image voxels are, therefore, segmented into populations of uniform attenuation based on knowledge of the human anatomy. The clustering procedure starts with an overspecified number of clusters followed by a merging process to group clusters with similar properties (redundant clusters) and removal of some undesired substructures using anatomical knowledge. The method is unsupervised, adaptive and allows the classification of both pre- or post-injection transmission images obtained using either coincident 68Ge or single-photon 137Cs sources into main tissue components in terms of attenuation coefficients. A high-quality transmission image of the scanner bed is obtained from a high statistics scan and added to the transmission image. The segmented transmission images are then forward projected to generate attenuation correction factors to be used for the reconstruction of the corresponding emission scan. The technique has been tested on a chest phantom simulating the lungs, heart cavity and the spine, the Rando-Alderson phantom, and whole-body clinical PET studies showing a remarkable improvement in image quality, a clear reduction of noise propagation from transmission into emission data allowing for reduction of transmission scan duration. There was very good correlation (R2 = 0.96) between maximum standardized uptake values (SUVs) in lung nodules measured on images reconstructed with measured and segmented attenuation correction with a statistically significant decrease in SUV (17.03% +/- 8.4%, P < 0.01) on the latter images, whereas no proof of statistically significant differences on the average SUVs was observed. Finally, the potential of the FCM algorithm as a segmentation method and its limitations as well as other prospective applications of the technique are discussed.

journal_name

Phys Med Biol

authors

Zaidi H,Diaz-Gomez M,Boudraa A,Slosman DO

doi

10.1088/0031-9155/47/7/310

subject

Has Abstract

pub_date

2002-04-07 00:00:00

pages

1143-60

issue

7

eissn

0031-9155

issn

1361-6560

journal_volume

47

pub_type

杂志文章
  • A Fourier rebinning algorithm incorporating spectral transfer efficiency for 3D PET.

    abstract::This paper presents a Fourier rebinning algorithm for three-dimensional image reconstruction in PET that incorporates the concept of spectral transfer function. It suggests the need for discarding low-frequency components in the rebinning. It also includes the correction for rebinning efficiency which was evaluated by...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/43/4/004

    authors: Tanaka E,Amo Y

    更新日期:1998-04-01 00:00:00

  • Scheduling cisplatin and radiotherapy in the treatment of squamous cell carcinomas of the head and neck: a modelling approach.

    abstract::The aim of the present work was to implement the kinetics of cisplatin into a previously developed tumour growth model and to simulate the combined cisplatin-radiotherapy treatment with the emphasis on time sequencing and scheduling of drug and radiation. An investigation into whether the effect of cisplatin-radiation...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/51/15/002

    authors: Marcu L,Bezak E,Olver I

    更新日期:2006-08-07 00:00:00

  • Automatic extraction of pectoral muscle in the MLO view of mammograms.

    abstract::A mammogram is the standard modality used for breast cancer screening. Computer-aided detection (CAD) approaches are helpful for improving breast cancer detection rates when applied to mammograms. However, automated analysis of a mammogram often leads to inaccurate results in the presence of the pectoral muscle. There...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/58/23/8493

    authors: Feudjio CK,Klein J,Tiedeu A,Colot O

    更新日期:2013-12-07 00:00:00

  • Reduction of scatter in breast CT yields improved microcalcification visibility.

    abstract::The inadequate visibility of microcalcifications-small calcium deposits that cue radiologists to early stages of cancer-is a major limitation in current designs of dedicated breast computed tomography (bCT). This limitation has previously been attributed to the constituent components, spatial resolution, and utilized ...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/1361-6560/abae07

    authors: Ghazi P

    更新日期:2020-12-04 00:00:00

  • Non-uniform depth scanning for proton therapy systems employing active energy variation.

    abstract::In proton scanning systems that employ active energy variation for depth modulation, a switch of the particle energy might typically require 1-2 s. For plans comprising many energy slices, these seconds could sum up to a non-negligible fraction of the total treatment duration. We have applied the Nyquist-Shannon sampl...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/53/9/N01

    authors: Kang JH,Wilkens JJ,Oelfke U

    更新日期:2008-05-07 00:00:00

  • Improved dose-calculation accuracy in proton treatment planning using a simplified Monte Carlo method verified with three-dimensional measurements in an anthropomorphic phantom.

    abstract::Treatment planning for proton tumor therapy requires a fast and accurate dose-calculation method. We have implemented a simplified Monte Carlo (SMC) method in the treatment planning system of the National Cancer Center Hospital East for the double-scattering beam delivery scheme. The SMC method takes into account the ...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/55/12/018

    authors: Hotta K,Kohno R,Takada Y,Hara Y,Tansho R,Himukai T,Kameoka S,Matsuura T,Nishio T,Ogino T

    更新日期:2010-06-21 00:00:00

  • CyberArc: a non-coplanar-arc optimization algorithm for CyberKnife.

    abstract::The goal of this study is to demonstrate the feasibility of a novel non-coplanar-arc optimization algorithm (CyberArc). This method aims to reduce the delivery time of conventional CyberKnife treatments by allowing for continuous beam delivery. CyberArc uses a 4 step optimization strategy, in which nodes, beams, and c...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/1361-6560/aa6f92

    authors: Kearney V,Cheung JP,McGuinness C,Solberg TD

    更新日期:2017-06-26 00:00:00

  • Laser speckle imaging of blood flow in microcirculation.

    abstract::Monitoring the spatio-temporal characteristics of microcirculation is crucial for studying the functional activities of biotissue and the mechanism of disease. However, conventional methods used to measure blood flow suffer from limited spatial resolution or the injection of exogenous substances or the need of scannin...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/49/7/020

    authors: Cheng H,Luo Q,Liu Q,Lu Q,Gong H,Zeng S

    更新日期:2004-04-07 00:00:00

  • Energy-resolved computed tomography: first experimental results.

    abstract::First experimental results with energy-resolved computed tomography (CT) are reported. The contrast-to-noise ratio (CNR) in CT has been improved with x-ray energy weighting for the first time. Further, x-ray energy weighting improved the CNR in material decomposition CT when applied to CT projections prior to dual-ene...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/53/20/002

    authors: Shikhaliev PM

    更新日期:2008-10-21 00:00:00

  • Systematic investigation of the signal properties of polycrystalline HgI2 detectors under mammographic, radiographic, fluoroscopic and radiotherapy irradiation conditions.

    abstract::The signal properties of polycrystalline mercuric iodide (HgI2) film detectors, under irradiation conditions relevant to mammographic, radiographic, fluoroscopic and radiotherapy x-ray imaging, are reported. Each film detector consists of an approximately 230 to approximately 460 microm thick layer of HgI2 (fabricated...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/50/12/012

    authors: Su Z,Antonuk LE,El-Mohri Y,Hu L,Du H,Sawant A,Li Y,Wang Y,Yamamoto J,Zhao Q

    更新日期:2005-06-21 00:00:00

  • The production of positron emitters with millisecond half-life during helium beam radiotherapy.

    abstract::Therapy with helium ions is currently receiving significantly increasing interest because helium ions have a sharper penumbra than protons and undergo less fragmentation than carbon ions and thus require less complicated dose calculations. For any ion of interest in hadron therapy, the accuracy of dose delivery is lim...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/1361-6560/ab51c3

    authors: Ozoemelam I,van der Graaf E,Brandenburg S,Dendooven P

    更新日期:2019-12-05 00:00:00

  • A comparison between the patella and the calcaneus using ultrasound velocity and attenuation as predictors of bone mineral density.

    abstract::The bone mineral density (BMD), ultrasound velocity (UV) and attenuation were examined in sixteen matched sets of human patellae and calcanei. For the sixteen calcanei, BMD was strongly correlated with all ultrasound parameters. Calcaneal UV appeared to be inferior to attenuation in the ability to predict BMD. For the...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/42/10/008

    authors: Han SM,Davis J

    更新日期:1997-10-01 00:00:00

  • Thoracic low-dose CT image processing using an artifact suppressed large-scale nonlocal means.

    abstract::The x-ray exposure to patients has become a major concern in computed tomography (CT) and minimizing the radiation exposure has been one of the major efforts in the CT field. Due to plenty high-attenuation tissues in the human chest, under low-dose scan protocols, thoracic low-dose CT (LDCT) images tend to be severely...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/57/9/2667

    authors: Chen Y,Yang Z,Hu Y,Yang G,Zhu Y,Li Y,Luo L,Chen W,Toumoulin C

    更新日期:2012-05-07 00:00:00

  • Systematic variations in polymer gel dosimeter calibration due to container influence and deviations from water equivalence.

    abstract::There are a number of gel dosimeter calibration methods in contemporary usage. The present study is a detailed Monte Carlo investigation into the accuracy of several calibration techniques. Results show that for most arrangements the dose to gel accurately reflects the dose to water, with the most accurate method invo...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/52/13/022

    authors: Taylor ML,Franich RD,Johnston PN,Millar RM,Trapp JV

    更新日期:2007-07-07 00:00:00

  • A radiographic technique for measuring the powder packing density in the cavities of trabecular bone.

    abstract::An X-ray technique has been developed to enable reproducible and quantitative data to be obtained from radiographs taken by a diagnostic X-ray machine. Careful attention has been paid to the alignment of the specimen and the diagnostic tube and to operating conditions. The choice of X-ray spectrum is described togethe...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/22/4/003

    authors: King SD

    更新日期:1977-07-01 00:00:00

  • Optimization of MAGIC gel formulation for three-dimensional radiation therapy dosimetry.

    abstract::Polymer gel dosimetry aims to provide three-dimensional images of radiation therapy dose distributions in irradiated aqueous gels. The first gels required manufacture in an oxygen-free environment, but later the MAGIC formulation was introduced, which could be made in normal atmospheric conditions. Here we report our ...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/52/10/N03

    authors: Luci JJ,Whitney HM,Gore JC

    更新日期:2007-05-21 00:00:00

  • A robust state-space kinetics-guided framework for dynamic PET image reconstruction.

    abstract::Dynamic PET image reconstruction is a challenging issue due to the low SNR and the large quantity of spatio-temporal data. We propose a robust state-space image reconstruction (SSIR) framework for activity reconstruction in dynamic PET. Unlike statistically-based frame-by-frame methods, tracer kinetic modeling is inco...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/56/8/010

    authors: Tong S,Alessio AM,Kinahan PE,Liu H,Shi P

    更新日期:2011-04-21 00:00:00

  • Characterization of diffraction-enhanced imaging contrast in breast cancer.

    abstract::Diffraction-enhanced imaging (DEI) is a new x-ray imaging modality that has been shown to enhance contrast between normal and cancerous breast tissues. In this study, diffraction-enhanced imaging in computed tomography (DEI-CT) mode was used to quantitatively characterize the refraction contrasts of the organized stru...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/54/10/019

    authors: Kao T,Connor D,Dilmanian FA,Faulconer L,Liu T,Parham C,Pisano ED,Zhong Z

    更新日期:2009-05-21 00:00:00

  • The local noise property in positron volume imaging and optimal conditions for the signal-to-noise ratio of the 3D reconstructed image.

    abstract::The local noise property of a 3D PET reconstructed image is investigated for a uniform-activity sphere distributed in a constantly attenuating spherical object. The positional dependence of the statistical noise is approximately derived and calculated for some special cases. It is suggested that a larger diameter of t...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/42/1/015

    authors: Murayama H,Nohara N

    更新日期:1997-01-01 00:00:00

  • Dead time correction and counting statistics for positron tomography.

    abstract::A correction for loss of events due to dead time in dynamic positron emission tomography (PET) is presented. The model employs a paralysing dead time to describe the behaviour of a tomograph over the range of event rates normally encountered in patient studies (up to 200 000 events/s per detector layer). The Donner 28...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/30/5/002

    authors: Mazoyer BM,Roos MS,Huesman RH

    更新日期:1985-05-01 00:00:00

  • A robust optimization method for weighted-layer-stacking proton beam therapy.

    abstract::The layer-stacking method can provide three-dimensional conformal dose distributions to the target based on a passive scattering method using mini-spread-out Bragg peak (SOBP). The purpose of this work is to demonstrate the effectiveness of a new weight optimization algorithm that can enhance the robustness of dose di...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/1361-6560/ab9efd

    authors: Sakamoto Y,Maeda Y,Yamada Y,Ikeda M,Tameshige Y,Sasaki M,Shibata S,Yamamoto K

    更新日期:2020-09-28 00:00:00

  • Arranging optical fibres for the spatial resolution improvement of topographical images.

    abstract::Optical topography is a method for visualization of conical activity. Ways of improving the spatial resolution of the topographical image with three arrangements of optical fibres are discussed. A distribution of sensitivity is obtained from the phantom experiment, and used to reconstruct topographical images of an ac...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/47/18/311

    authors: Yamamoto T,Maki A,Kadoya T,Tanikawa Y,Yamad Y,Okada E,Koizumi H

    更新日期:2002-09-21 00:00:00

  • PBS machine interlocks using EWMA.

    abstract::Delivery of pencil beam scanning (PBS) requires the on-line measurement of several beam parameters. If the measurement is outside of specified tolerances and a binary threshold algorithm is used, the beam will be paused. Given instrumentation and statistical noise such a system can lead to many pauses which could incr...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/61/1/400

    authors: Clasie BM,Kooy HM,Flanz JB

    更新日期:2016-01-07 00:00:00

  • An efficient strategy based on an individualized selection of registration methods. Application to the coregistration of MR and SPECT images in neuro-oncology.

    abstract::An efficient registration strategy is described that aims to help solve delicate medical imaging registration problems. It consists of running several registration methods for each dataset and selecting the best one for each specific dataset, according to an evaluation criterion. Finally, the quality of the registrati...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/59/22/6997

    authors: Tacchella JM,Roullot E,Lefort M,Cohen ME,Guillevin R,Petrirena G,Delattre JY,Habert MO,Yeni N,Kas A,Frouin F

    更新日期:2014-11-21 00:00:00

  • Motion correction of respiratory-gated PET images using deep learning based image registration framework.

    abstract::Artifacts caused by patient breathing and movement during PET data acquisition affect image quality. Respiratory gating is commonly used to gate the list-mode PET data into multiple bins over a respiratory cycle. Non-rigid registration of respiratory-gated PET images can reduce motion artifacts and preserve count stat...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/1361-6560/ab8688

    authors: Li T,Zhang M,Qi W,Asma E,Qi J

    更新日期:2020-07-30 00:00:00

  • Assessment of histotripsy-induced liquefaction with diagnostic ultrasound and magnetic resonance imaging in vitro and ex vivo.

    abstract::Histotripsy is a therapeutic ultrasound modality under development to liquefy tissue mechanically via bubble clouds. Image guidance of histotripsy requires both quantification of the bubble cloud activity and accurate delineation of the treatment zone. In this study, magnetic resonance (MR) and diagnostic ultrasound i...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/1361-6560/ab143f

    authors: Anthony GJ,Bollen V,Hendley S,Antic T,Sammet S,Bader KB

    更新日期:2019-05-02 00:00:00

  • Collapsed cone convolution and analytical anisotropic algorithm dose calculations compared to VMC++ Monte Carlo simulations in clinical cases.

    abstract::The purpose of this work was to study and quantify the differences in dose distributions computed with some of the newest dose calculation algorithms available in commercial planning systems. The study was done for clinical cases originally calculated with pencil beam convolution (PBC) where large density inhomogeneit...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/52/13/002

    authors: Hasenbalg F,Neuenschwander H,Mini R,Born EJ

    更新日期:2007-07-07 00:00:00

  • NEMA NU 4-2008 validation and applications of the PET-SORTEO Monte Carlo simulations platform for the geometry of the Inveon PET preclinical scanner.

    abstract::Monte Carlo-based simulation of positron emission tomography (PET) data plays a key role in the design and optimization of data correction and processing methods. Our first aim was to adapt and configure the PET-SORTEO Monte Carlo simulation program for the geometry of the widely distributed Inveon PET preclinical sca...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/58/19/6749

    authors: Boisson F,Wimberley CJ,Lehnert W,Zahra D,Pham T,Perkins G,Hamze H,Gregoire MC,Reilhac A

    更新日期:2013-10-07 00:00:00

  • Effects of bone- and air-tissue inhomogeneities on the dose distributions of the Leksell Gamma Knife calculated with PENELOPE.

    abstract::Monte Carlo simulation with PENELOPE (version 2003) is applied to calculate Leksell Gamma Knife dose distributions for heterogeneous phantoms. The usual spherical water phantom is modified with a spherical bone shell simulating the skull and an air-filled cube simulating the frontal or maxillary sinuses. Different sim...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/50/23/018

    authors: Al-Dweri FM,Rojas EL,Lallena AM

    更新日期:2005-12-07 00:00:00

  • A breathing thorax phantom with independently programmable 6D tumour motion for dosimetric measurements in radiation therapy.

    abstract::Irradiation of moving targets using a scanned ion beam can cause clinically intolerable under- and overdosages within the target volume due to the interplay effect. Several motion mitigation techniques such as gating, beam tracking and rescanning are currently investigated to overcome this restriction. To enable detai...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/57/8/2235

    authors: Steidl P,Richter D,Schuy C,Schubert E,Haberer T,Durante M,Bert C

    更新日期:2012-04-21 00:00:00