Abstract:
:In the field of regenerative medicine, there has been a growing interest in studying the combination of bone scaffolds and cells that can maximize newly formed bone. In-line phase-contrast x-ray tomography was used to image porous bone scaffolds (Skelite(©)), seeded with bone forming cells. This technique allows the quantification of both mineralized and soft tissue, unlike with classical x-ray micro-computed tomography. Phase contrast images were acquired at four distances. The reconstruction is typically performed in two successive steps: phase retrieval and tomographic reconstruction. In this work, different regularization methods were applied to the phase retrieval process. The application of a priori terms for heterogeneous objects enables quantitative 3D imaging of not only bone morphology, mineralization, and soft tissue formation, but also cells trapped in the pre-bone matrix. A statistical study was performed to derive statistically significant information on the different culture conditions.
journal_name
Phys Med Bioljournal_title
Physics in medicine and biologyauthors
Weber L,Langer M,Tavella S,Ruggiu A,Peyrin Fdoi
10.1088/0031-9155/61/9/N215subject
Has Abstractpub_date
2016-05-07 00:00:00pages
N215-31issue
9eissn
0031-9155issn
1361-6560journal_volume
61pub_type
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