Abstract:
:Due to high levels of noise in pixel-wise time-activity curves, the indirect method that generates kinetic parametric images from dynamic positron emission tomography (PET) images often results in poor parametric image quality. We have demonstrated that the quality of parametric images can be improved by denoising dynamic PET images, using gradient-free curve-fitting and applying a kernel-based post-filtering to parametric images. However, many gradient-free curve-fitting methods are time-consuming. Moreover, some parameter estimates (e.g. k2 and k3) have large variability. To provide high-quality PET parametric images with low computational cost, we propose a curve-fitting method that incorporates the kernel-based denoising method and the highly constrained backprojection technique into the Levenberg-Marquardt (LM) algorithm. We conducted a simulation study to evaluate the performance of the proposed curve-fitting method. Dynamic PET images were reconstructed using the expectation-maximization (EM) algorithm and were denoised before parameter estimation. Compared to the LM algorithm with and without the kernel-based post-filtering, the proposed method achieved superior performance, offering a decrease in both bias and coefficient of variation (CV) on all parametric images. Overall, the proposed method exhibited lower bias and slightly higher CV than the gradient-free pattern search method with the kernel-based post-filtering (PatS-K). Moreover, the computation time of the proposed method was about 18 times lower than that of the PatS-K method. Finally, we show that the proposed method can further improve the quality of parametric images when dynamic PET images are reconstructed using the kernel-based EM algorithm.
journal_name
Phys Med Bioljournal_title
Physics in medicine and biologyauthors
Huang HMdoi
10.1088/1361-6560/abb1d8subject
Has Abstractpub_date
2020-11-17 00:00:00pages
225006issue
22eissn
0031-9155issn
1361-6560journal_volume
65pub_type
杂志文章abstract::The objective of this paper is to evaluate an iterative maximum likelihood (ML) cone-beam computed tomography (CBCT) reconstruction with total variation (TV) regularization with respect to the robustness of the algorithm due to data inconsistencies. Three different and (for clinical application) typical classes of err...
journal_title:Physics in medicine and biology
pub_type: 杂志文章
doi:10.1088/0031-9155/57/19/5955
更新日期:2012-10-07 00:00:00
abstract::A non-contact approach for diffuse optical tomography (DOT) has been developed for on-demand image updates using surgical navigation technology. A stereoscopic optical tracker provides real-time localization of reflective spheres mounted to a laser diode and near-infrared camera. Standard camera calibration is combine...
journal_title:Physics in medicine and biology
pub_type: 杂志文章
doi:10.1088/1361-6560/ab1f33
更新日期:2019-07-05 00:00:00
abstract::Sparse-view CT reconstruction algorithms via total variation (TV) optimize the data iteratively on the basis of a noise- and artifact-reducing model, resulting in significant radiation dose reduction while maintaining image quality. However, the piecewise constant assumption of TV minimization often leads to the appea...
journal_title:Physics in medicine and biology
pub_type: 杂志文章
doi:10.1088/0031-9155/59/12/2997
更新日期:2014-06-21 00:00:00
abstract::The behaviour of scatter dose in 4 and 8 MV wedged x-ray beams has been studied by calculating scatter-to-primary dose ratios (SPR) and comparing these with SPR for non-wedged beams. On the central axis the SPR for wedged and non-wedged beams differ only by a few per cent, a difference which increases slightly with we...
journal_title:Physics in medicine and biology
pub_type: 杂志文章
doi:10.1088/0031-9155/32/10/010
更新日期:1987-10-01 00:00:00
abstract::A theoretical analysis and numerical solutions are presented for viscosity-dominated flow through a uniform, highly distensible tube with a slit-shaped cross section undergoing peristalsis. At flow rates below an intrinsic upper limit to the peristaltic carrying capacity of the tube, provided that there is always at l...
journal_title:Physics in medicine and biology
pub_type: 杂志文章
doi:10.1088/0031-9155/32/7/002
更新日期:1987-07-01 00:00:00
abstract::This work describes the dosimetric commissioning of the treatment planning system (TPS) RayStation v6.1 from RaySearch Laboratories (Stockholm, Sweden) for a synchrotron-based scanned proton beam delivery with isocentric and non-isocentric setups at MedAustron. Focus was on the comparison of the pencil beam (PBv4.1) a...
journal_title:Physics in medicine and biology
pub_type: 杂志文章
doi:10.1088/1361-6560/ab3557
更新日期:2019-08-28 00:00:00
abstract::At certain frequencies, when the human head becomes a resonant structure, the power absorbed by the head and neck, when the body is exposed to a vertically polarized plane wave propagating from front to back, becomes significantly larger than would ordinarily be expected from its shadow cross section. This has possibl...
journal_title:Physics in medicine and biology
pub_type: 杂志文章
doi:10.1088/0031-9155/43/8/026
更新日期:1998-08-01 00:00:00
abstract::Dose to water (Dw) determination in clinical high-energy photon beams with ionization chambers calibrated in terms of absorbed dose to water has been proposed as an alternative to ionization chamber dosimetry based on air kerma calibrations. Dw in the clinical beam is derived using a kappaQ factor that scales the abso...
journal_title:Physics in medicine and biology
pub_type: 杂志文章
doi:10.1088/0031-9155/44/3/002
更新日期:1999-03-01 00:00:00
abstract::Advanced radiotherapeutical techniques like intensity-modulated radiation therapy (IMRT) are based on an accurate knowledge of the location of the radiation target. An accurate dose delivery, therefore, requires a method to account for the inter- and intrafractional target motion and the target deformation occurring d...
journal_title:Physics in medicine and biology
pub_type: 杂志文章
doi:10.1088/0031-9155/52/22/N01
更新日期:2007-11-21 00:00:00
abstract::A method will be described for determining the centre of rotation of a mechanically scanned reflection ultrasound computed tomography system. It is based on the principle of obtaining opposing images of a test object containing many point targets. The method is automatic in the sense that the centre of rotation is cal...
journal_title:Physics in medicine and biology
pub_type: 杂志文章
doi:10.1088/0031-9155/39/12/017
更新日期:1994-12-01 00:00:00
abstract::The inadequate visibility of microcalcifications-small calcium deposits that cue radiologists to early stages of cancer-is a major limitation in current designs of dedicated breast computed tomography (bCT). This limitation has previously been attributed to the constituent components, spatial resolution, and utilized ...
journal_title:Physics in medicine and biology
pub_type: 杂志文章
doi:10.1088/1361-6560/abae07
更新日期:2020-12-04 00:00:00
abstract::This study aims to develop and test software for assessing and reporting doses for standard patients undergoing computed tomography (CT) examinations in a 320 detector-row cone-beam scanner. The software, called SimDoseCT, is based on the Monte Carlo (MC) simulation code, which was developed to calculate organ doses a...
journal_title:Physics in medicine and biology
pub_type: 杂志文章
doi:10.1088/1361-6560/aa77ea
更新日期:2017-07-17 00:00:00
abstract::Enabling automated pipelines, image analysis and big data methodology in cancer clinics requires thorough understanding of the data. Automated quality assurance steps could improve the efficiency and robustness of these methods by verifying possible data biases. In particular, in head and neck (H&N) computed-tomograph...
journal_title:Physics in medicine and biology
pub_type: 杂志文章
doi:10.1088/1361-6560/ab5427
更新日期:2020-01-10 00:00:00
abstract::The imaging performance of a high-resolution preclinical micro-positron emission tomography (micro-PET) system employing liquid xenon (LXe) as the gamma-ray detection medium was simulated. The arrangement comprises a ring of detectors consisting of trapezoidal LXe time projection ionization chambers and two arrays of ...
journal_title:Physics in medicine and biology
pub_type: 杂志文章
doi:10.1088/0031-9155/57/6/1685
更新日期:2012-03-21 00:00:00
abstract::Oxygen ([Formula: see text]) ions are a potential alternative to carbon ions in ion beam therapy. Their enhanced linear energy transfer indicates a higher relative biological effectiveness and a reduced oxygen enhancement ratio. Due to the limited availability of [Formula: see text] ion beams, Monte Carlo (MC) transpo...
journal_title:Physics in medicine and biology
pub_type: 杂志文章
doi:10.1088/1361-6560/aa807e
更新日期:2017-09-05 00:00:00
abstract::Our goal was to develop a method for generating high-resolution three-dimensional pulmonary compliance images in rodents from computed tomography (CT) images acquired at a series of constant pressures in ventilated animals. One rat and one mouse were used to demonstrate this technique. A pre-clinical GE flat panel CT ...
journal_title:Physics in medicine and biology
pub_type: 杂志文章
doi:10.1088/0031-9155/51/5/003
更新日期:2006-03-07 00:00:00
abstract::The fluence to organ-dose and effective-dose conversion coefficients for neutrons and protons with energies up to 100 GeV was calculated using the PHITS code coupled to male and female adult reference computational phantoms, which are to be released as a common ICRP/ICRU publication. For the calculation, the radiation...
journal_title:Physics in medicine and biology
pub_type: 杂志文章
doi:10.1088/0031-9155/54/7/009
更新日期:2009-04-07 00:00:00
abstract::The intra- and inter-batch accuracy and precision of MRI (polyacrylamide gelatin gel fabricated at atmospheric conditions) polymer gel dosimeters are assessed in full 3D. In the intra-batch study, eight spherical flasks were filled with the same polymer gel along with a set of test tubes that served as calibration pha...
journal_title:Physics in medicine and biology
pub_type: 杂志文章
doi:10.1088/0031-9155/58/1/19
更新日期:2013-01-07 00:00:00
abstract::A thermal model for predicting time-dependent temperature distributions during ultrasound heating was tested quantitatively. The relevant thermal processes incorporated in the model are heat conduction and ultrasound power absorption, and the required input parameters include the absolute ultrasound power, the shape a...
journal_title:Physics in medicine and biology
pub_type: 杂志文章
doi:10.1088/0031-9155/36/9/001
更新日期:1991-09-01 00:00:00
abstract::Scanned ion pencil beams carry a low-dose envelope which can extend up to several centimeters from the individual beam central axis. Depending on the energy and species of the beam, this halo consists mainly of secondary particles produced by nuclear interactions in the target or of particles undergoing multiple Coulo...
journal_title:Physics in medicine and biology
pub_type: 杂志文章
doi:10.1088/0031-9155/56/24/009
更新日期:2011-12-21 00:00:00
abstract::In this study, we explore the potential of compressed sensing (CS) accelerated broadband 3D phase-encoded turbo spin-echo (3D-PE-TSE) for the purpose of geometrically undistorted imaging in the presence of field inhomogeneities. To achieve this goal 3D-PE-SE and 3D-PE-TSE sequences with broadband rf pulses and dedicat...
journal_title:Physics in medicine and biology
pub_type: 杂志文章
doi:10.1088/0031-9155/60/2/615
更新日期:2015-01-21 00:00:00
abstract::Radiotherapy and particle therapy treatment planning require accurate knowledge of the electron density and elemental composition of the tissues in the beam path to predict the local dose deposition. We describe a method for the analysis of dual energy computed tomography (DECT) images that provides the electron densi...
journal_title:Physics in medicine and biology
pub_type: 杂志文章
doi:10.1088/0031-9155/60/9/3825
更新日期:2015-05-07 00:00:00
abstract::Positron emission tomography (PET) has become an important modality in medical and molecular imaging. However, in most PET applications, the resolution is still mainly limited by the physical crystal sizes or the detector's intrinsic spatial resolution. To achieve images with better spatial resolution in a central reg...
journal_title:Physics in medicine and biology
pub_type: 杂志文章
doi:10.1088/0031-9155/60/2/647
更新日期:2015-01-21 00:00:00
abstract::This paper investigates the feasibility of a scanned cylindrical ultrasound system for producing uniform heating from the central to the superficial portions of the breast or localized heating within the breast at a specific location. The proposed system consists of plane ultrasound transducer(s) mounted on a scanned ...
journal_title:Physics in medicine and biology
pub_type: 杂志文章
doi:10.1088/0031-9155/51/3/005
更新日期:2006-02-07 00:00:00
abstract::Techniques for reducing computation time in 3D photon dose calculations are addressed with specific emphasis given to the convolution/superposition approach. A single polyenergetic superposition model calculating absorbed dose per incident photon fluence (Gy cm2) was developed in terms of TERMA and a total energy depo...
journal_title:Physics in medicine and biology
pub_type: 杂志文章
doi:10.1088/0031-9155/42/8/001
更新日期:1997-08-01 00:00:00
abstract::In previous work we demonstrated the potential of positron emission tomography (PET) detectors with depth-of-interaction (DOI) encoding capability based on phosphor-coated crystals. A DOI resolution of 8 mm full-width at half-maximum was obtained for 20 mm long scintillator crystals using a delayed charge integration ...
journal_title:Physics in medicine and biology
pub_type: 杂志文章
doi:10.1088/0031-9155/57/20/6571
更新日期:2012-10-21 00:00:00
abstract::We propose a completely automated algorithm for the detection of the spinal centreline and the centres of vertebral bodies and intervertebral discs in images acquired by computed tomography (CT) and magnetic resonance (MR) imaging. The developed methods are based on the analysis of the geometry of spinal structures an...
journal_title:Physics in medicine and biology
pub_type: 杂志文章
doi:10.1088/0031-9155/55/1/015
更新日期:2010-01-07 00:00:00
abstract::An optimized configuration of multi-pinhole aperture can improve the spatial resolution and the sensitivity of pinhole SPECT simultaneously. In this study, an optimization strategy of the multi-pinhole configuration with a small detector is proposed for mouse cardiac imaging. A 14 mm-diameter spherical field-of-view (...
journal_title:Physics in medicine and biology
pub_type: 杂志文章
doi:10.1088/0031-9155/60/2/473
更新日期:2015-01-21 00:00:00
abstract::Practical dosimeters in brachytherapy, such as thermoluminescent dosimeters (TLD) and diodes, are usually calibrated against low-energy megavoltage beams. To measure absolute dose rate near a brachytherapy source, it is necessary to establish the energy response of the detector relative to that of the calibration ener...
journal_title:Physics in medicine and biology
pub_type: 杂志文章
doi:10.1088/0031-9155/41/6/004
更新日期:1996-06-01 00:00:00
abstract::This study aims to build a feasible mathematical model to analyze the mass evolution of NSCLC during standard fractionated radiotherapy. Seventy-three cases of NSCLC who were received radiotherapy with prescription dose of 2 Gy × 30 fx were selected retrospectively and divided into adenocarcinoma (ADC) group and squ...
journal_title:Physics in medicine and biology
pub_type: 杂志文章
doi:10.1088/1361-6560/ab47c0
更新日期:2019-11-26 00:00:00