Characterization of diffraction-enhanced imaging contrast in breast cancer.

Abstract:

:Diffraction-enhanced imaging (DEI) is a new x-ray imaging modality that has been shown to enhance contrast between normal and cancerous breast tissues. In this study, diffraction-enhanced imaging in computed tomography (DEI-CT) mode was used to quantitatively characterize the refraction contrasts of the organized structures associated with invasive human breast cancer. Using a high-sensitivity Si (3 3 3) reflection, the individual features of breast cancer, including masses, calcifications and spiculations, were observed. DEI-CT yields 14, 5 and 7 times higher CT numbers and 10, 9 and 6 times higher signal-to-noise ratios (SNR) for masses, calcifications and spiculations, respectively, as compared to conventional CT of the same specimen performed using the same detector, x-ray energy and dose. Furthermore, DEI-CT at ten times lower dose yields better SNR than conventional CT. In light of the recent development of a compact DEI prototype using an x-ray tube as its source, these results, acquired at a clinically relevant x-ray energy for which a pre-clinical DEI prototype currently exists, suggest the potential of clinical implementation of mammography with DEI-CT to provide high-contrast, high-resolution images of breast cancer (Parham 2006 PhD Dissertation University of North Carolina at Chapel Hill).

journal_name

Phys Med Biol

authors

Kao T,Connor D,Dilmanian FA,Faulconer L,Liu T,Parham C,Pisano ED,Zhong Z

doi

10.1088/0031-9155/54/10/019

subject

Has Abstract

pub_date

2009-05-21 00:00:00

pages

3247-56

issue

10

eissn

0031-9155

issn

1361-6560

pii

S0031-9155(09)94922-3

journal_volume

54

pub_type

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