Treatment plan modification using voxel-based weighting factors/dose prescription.

Abstract:

:Under various clinical situations, it is desirable to modify the original treatment plan to better suit the clinical goals. In this work, a method to help physicians modify treatment plans based on their clinical preferences is proposed. The method uses a weighted quadratic dose objective function. The commonly used organ-/ROI-based weighting factors are expanded to a set of voxel-based weighting factors in order to obtain greater flexibility in treatment plan modification. Two different but equivalent modification schemes based on Rustem's quadratic programming algorithms--modification of a weighting matrix and modification of prescribed doses--are presented. Case studies demonstrated the effectiveness of the two methods with regard to their capability to fine-tune treatment plans.

journal_name

Phys Med Biol

authors

Wu C,Olivera GH,Jeraj R,Keller H,Mackie TR

doi

10.1088/0031-9155/48/15/315

subject

Has Abstract

pub_date

2003-08-07 00:00:00

pages

2479-91

issue

15

eissn

0031-9155

issn

1361-6560

journal_volume

48

pub_type

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