Abstract:
:Under various clinical situations, it is desirable to modify the original treatment plan to better suit the clinical goals. In this work, a method to help physicians modify treatment plans based on their clinical preferences is proposed. The method uses a weighted quadratic dose objective function. The commonly used organ-/ROI-based weighting factors are expanded to a set of voxel-based weighting factors in order to obtain greater flexibility in treatment plan modification. Two different but equivalent modification schemes based on Rustem's quadratic programming algorithms--modification of a weighting matrix and modification of prescribed doses--are presented. Case studies demonstrated the effectiveness of the two methods with regard to their capability to fine-tune treatment plans.
journal_name
Phys Med Bioljournal_title
Physics in medicine and biologyauthors
Wu C,Olivera GH,Jeraj R,Keller H,Mackie TRdoi
10.1088/0031-9155/48/15/315subject
Has Abstractpub_date
2003-08-07 00:00:00pages
2479-91issue
15eissn
0031-9155issn
1361-6560journal_volume
48pub_type
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