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On the impact of longitudinal breathing motion randomness for tomotherapy delivery.

Abstract：

:The purpose of this study is to explain the unplanned longitudinal dose modulations that appear in helical tomotherapy (HT) dose distributions in the presence of irregular patient breathing. This explanation is developed by the use of longitudinal (1D) simulations of mock and surrogate data and tested with a fully 4D HT delivered plan. The 1D simulations use a typical mock breathing function which allows more flexibility to adjust various parameters. These simplified simulations are then made more realistic by using 100 surrogate waveforms all similarly scaled to produce longitudinal breathing displacements. The results include the observation that, with many waveforms used simultaneously, a voxel-by-voxel probability of a dose error from breathing is found to be proportional to the realistically random breathing amplitude relative to the beam width if the PTV is larger than the beam width and the breathing displacement amplitude. The 4D experimental test confirms that regular breathing will not result in these modulations because of the insensitivity to leaf motion for low-frequency dynamics such as breathing. These modulations mostly result from a varying average of the breathing displacements along the beam edge gradients. Regular breathing has no displacement variation over many breathing cycles. Some low-frequency interference is also possible in real situations. In the absence of more sophisticated motion management, methods that reduce the breathing amplitude or make the breathing very regular are indicated. However, for typical breathing patterns and magnitudes, motion management techniques may not be required with HT because typical breathing occurs mostly between fundamental HT treatment temporal and spatial scales. A movement beyond only discussing margins is encouraged for intensity modulated radiotherapy such that patient and machine motion interference will be minimized and beneficial averaging maximized. These results are found for homogeneous and longitudinal on-axis delivery for unplanned longitudinal dose modulations.

journal_name

Phys Med Biol

journal_title

Physics in medicine and biology

authors

Kissick MW,Flynn RT,Westerly DC,Hoban PW,Mo X,Soisson ET,McCall KC,Mackie TR,Jeraj R

doi

10.1088/0031-9155/53/18/001

subject

Has Abstract

pub_date

2008-09-21 00:00:00

pages

4855-73

issue

eissn

0031-9155

issn

1361-6560

pii

S0031-9155(08)79379-5

journal_volume

pub_type

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On the impact of longitudinal breathing motion randomness for tomotherapy delivery.