Abstract:
:Computational simulations, such as Monte Carlo track structure simulations, offer a powerful tool for quantitatively investigating radiation interactions within cells. The modelling of the spatial distribution of energy deposition events as well as diffusion of chemical free radical species, within realistic biological geometries, can help provide a comprehensive understanding of the effects of radiation on cells. Track structure simulations, however, generally require advanced computing skills to implement. The TOPAS-nBio toolkit, an extension to TOPAS (TOol for PArticle Simulation), aims to provide users with a comprehensive framework for radiobiology simulations, without the need for advanced computing skills. This includes providing users with an extensive library of advanced, realistic, biological geometries ranging from the micrometer scale (e.g. cells and organelles) down to the nanometer scale (e.g. DNA molecules and proteins). Here we present the geometries available in TOPAS-nBio.
journal_name
Phys Med Bioljournal_title
Physics in medicine and biologyauthors
McNamara AL,Ramos-Méndez J,Perl J,Held K,Dominguez N,Moreno E,Henthorn NT,Kirkby KJ,Meylan S,Villagrasa C,Incerti S,Faddegon B,Paganetti H,Schuemann Jdoi
10.1088/1361-6560/aad8ebsubject
Has Abstractpub_date
2018-09-06 00:00:00pages
175018issue
17eissn
0031-9155issn
1361-6560journal_volume
63pub_type
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